{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:41:04Z","timestamp":1792784464226,"version":"4.5.0"},"reference-count":31,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100009377","name":"Education Department of Hunan Province","doi-asserted-by":"publisher","award":["24B0427"],"award-info":[{"award-number":["24B0427"]}],"id":[{"id":"10.13039\/100009377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["225QN293"],"award-info":[{"award-number":["225QN293"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Outstanding Youth Foundation of Hunan Province","award":["2024JJ2047"],"award-info":[{"award-number":["2024JJ2047"]}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["22374065"],"award-info":[{"award-number":["22374065"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Furong Plan Young Talent Program","award":["2925BH001"],"award-info":[{"award-number":["2925BH001"]}]},{"name":"Natural Science Foundation of?Hunan Province","award":["2024JJ6374"],"award-info":[{"award-number":["2024JJ6374"]}]},{"name":"Natural Science Foundation of?Hunan Province","award":["2025JJ50563"],"award-info":[{"award-number":["2025JJ50563"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), offers a minimally invasive approach with precise spatiotemporal control for cancer treatment. However, conventional photosensitizers are prone to aggregation-caused quenching, which lowers quantum yields, while their short wavelengths limit tissue penetration. Aggregation-induced emission luminogens (AIEgens) provide an effective solution. Although rotor engineering has enabled the development of AIEgens with improved quantum yields and red-shifted emission, current studies still focus mainly on single-rotor systems. In particular, triphenylamine (TPA) and tetraphenylethylene (TPE), two widely used rotor motifs in AIE systems, have rarely been systematically compared to clarify their distinct photophysical roles or cooperatively integrated for optical regulation. Here, two donor\u2013acceptor AIEgens, TPAFA and TPEFA, were designed to elucidate the photophysical impact of cross-rotor coassembly. TPAFA exhibits intense NIR-II fluorescence but displays limited photothermal effects, whereas TPEFA shows enhanced NIR-II absorption and photothermal efficiency, albeit with diminished emission. Leveraging their complementary strengths, cross-rotor coassembly of TPAFA and TPEFA with disulfide-linked PEG generated glutathione-responsive nanoparticles. This strategy preserved the bright emission of the TPAFA component and the long-wavelength photothermal activity of the TPEFA component, enabling NIR-II fluorescence imaging and 808\/1064 nm dual-band PTT with improved deep-tissue applicability. With 97.29% tumor inhibition in vivo and good biocompatibility, this study demonstrates that cross-rotor integration is an effective strategy for functionally integrating complementary fluorescence-emission and therapy-related energy-dissipation properties, thereby enabling the rational design of AIEgens for NIR-II-associated phototheranostic applications.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c02694","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:02:19Z","timestamp":1790301739000},"page":"28798-28809","source":"Crossref","is-referenced-by-count":0,"title":["Cross-Rotor Coassembly of AIEgens for Dual-NIR-II\nLaser-Enhanced Imaging-Guided Phototheranostics"],"prefix":"10.1021","volume":"98","author":[{"given":"Gui-long","family":"Wu","sequence":"first","affiliation":[{"name":"University of South China , , , ,","place":["Hengyang, Hunan, China, 421001"]},{"name":"University of South China , , , ,","place":["Hengyang, Hunan, China, 421001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Wu","sequence":"additional","affiliation":[{"name":"University of South China , , , ,","place":["Hengyang, Hunan, China, 421001"]},{"name":"University of South China , , , ,","place":["Hengyang, Hunan, China, 421001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hougeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Hainan Normal University , , ,","place":["Haikou, China, 571158"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinying","family":"Liu","sequence":"additional","affiliation":[{"name":"University of South China , , , ,","place":["Hengyang, Hunan, China, 421001"]},{"name":"University of South China , , , ,","place":["Hengyang, Hunan, China, 421001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Wang","sequence":"additional","affiliation":[{"name":"University of South China , , , ,","place":["Hengyang, Hunan, China, 421001"]},{"name":"University of South China , , , ,","place":["Hengyang, Hunan, China, 421001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"University of South China , , , ,","place":["Hengyang, Hunan, China, 421001"]},{"name":"University of South China , , , ,","place":["Hengyang, Hunan, China, 421001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Liu","sequence":"additional","affiliation":[{"name":"University of South China , , , ,","place":["Hengyang, Hunan, China, 421001"]},{"name":"University of South China , , , ,","place":["Hengyang, Hunan, China, 421001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Tan","sequence":"additional","affiliation":[{"name":"University of South China , , , ,","place":["Hengyang, Hunan, China, 421001"]},{"name":"University of South China , , , ,","place":["Hengyang, Hunan, China, 421001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tang","sequence":"additional","affiliation":[{"name":"Hainan Normal University , , ,","place":["Haikou, China, 571158"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9886-5384","authenticated-orcid":true,"given":"Qinglai","family":"Yang","sequence":"additional","affiliation":[{"name":"University of South China , , , ,","place":["Hengyang, Hunan, China, 421001"]},{"name":"University of South China , , , ,","place":["Hengyang, Hunan, China, 421001"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"issue":"1","key":"2026100608073466900_cit1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41392-024-02108-4","article-title":"Breast cancer: pathogenesis and treatments","volume":"10","author":"Xiong","year":"2025","journal-title":"Signal Transduction Targeted Ther."},{"issue":"10512","key":"2026100608073466900_cit2","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1016\/S0140-6736(25)01635-6","article-title":"The global,\nregional, and national burden of cancer, 1990\u20132023, with forecasts\nto 2050: a systematic analysis for the Global Burden of Disease Study\n2023","volume":"406","author":"GBD 2023 Cancer Collaborators.","year":"2025","journal-title":"Lancet"},{"key":"2026100608073466900_cit3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nrc.2017.109","article-title":"Targeting\nmutant\np53 for efficient cancer therapy","volume":"18","author":"Bykov","year":"2018","journal-title":"Nat. Rev.\nCancer"},{"key":"2026100608073466900_cit4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nri.2017.97","article-title":"Complement in cancer:\nuntangling an intricate relationship","volume":"18","author":"Reis","year":"2018","journal-title":"Nat. Rev.\nImmunol."},{"key":"2026100608073466900_cit5","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.4564","article-title":"Efficacy and Safety of Nivolumab\nPlus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma\nPreviously Treated With Sorafenib: The CheckMate 040 Randomized Clinical\nTrial","volume":"6","author":"Yau","year":"2020","journal-title":"JAMA Oncol."},{"key":"2026100608073466900_cit6","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3390\/cells13020187","article-title":"Cannabidiol\nCombination Enhances\nPhotodynamic Therapy Effects on MCF-7 Breast Cancer Cells","volume":"13","author":"Mokoena","year":"2024","journal-title":"Cells"},{"issue":"9","key":"2026100608073466900_cit7","doi-asserted-by":"publisher","first-page":"2416317","DOI":"10.1002\/adfm.202416317","article-title":"Synergistic Phototherapy Using Zwitterionic Crystalline\nNanoaggregates of Orthogonal Donor\u2013Acceptor Small-Molecule\nDyads","volume":"35","author":"Hao","year":"2025","journal-title":"Adv. Funct. Mater."},{"issue":"49","key":"2026100608073466900_cit8","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adx4850","article-title":"Mitochondria-localized photocatalyst\nof biomimetic organic semiconductor nanoparticles for NIR-activatable\nphotocatalytic immunotherapy","volume":"11","author":"Wang","year":"2025","journal-title":"Sci. Adv."},{"issue":"2","key":"2026100608073466900_cit9","doi-asserted-by":"publisher","first-page":"20220011","DOI":"10.1002\/EXP.20220011","article-title":"Tracking tumor heterogeneity and\nprogression with near-infrared II fluorophores","volume":"3","author":"Xin","year":"2023","journal-title":"Exploration"},{"key":"2026100608073466900_cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-025-01593-4","article-title":"Label-free\ntissue NIR-II autofluorescence imaging for visualization of human\nliver malignancy","author":"He","year":"2026","journal-title":"Nat. Biomed. Eng."},{"key":"2026100608073466900_cit11","doi-asserted-by":"publisher","first-page":"14593","DOI":"10.1021\/jacs.6c02935","article-title":"Tandem Auxochrome Design\nEnables Ready Access to Deep Shortwave Infrared Dyes","volume":"148","author":"Yan","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026100608073466900_cit12","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/s41551-023-01083-5","article-title":"Shortwave-infrared-light-emitting\nprobes for the in vivo tracking of cancer vaccines and the elicited\nimmune responses","volume":"8","author":"Ren","year":"2024","journal-title":"Nat. Biomed. Eng."},{"key":"2026100608073466900_cit13","doi-asserted-by":"publisher","first-page":"123193","DOI":"10.1016\/j.biomaterials.2025.123193","article-title":"Multi-dimensional\ndonor engineering of NIR-II AIEgens for multimodal phototheranostics\nof orthotopic breast cancer","volume":"319","author":"Yuan","year":"2025","journal-title":"Biomaterials"},{"key":"2026100608073466900_cit14","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/s41591-023-02786-7","article-title":"Adjuvant sintilimab\nin resected high-risk hepatocellular carcinoma: a randomized, controlled,\nphase 2 trial","volume":"30","author":"Wang","year":"2024","journal-title":"Nat. Med."},{"issue":"18","key":"2026100608073466900_cit15","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1039\/b105159h","article-title":"Aggregation-induced\nemission of 1-methyl-1,2,3,4,5-pentaphenylsilole","volume":"37","author":"Luo","year":"2001","journal-title":"Chem. Commun."},{"key":"2026100608073466900_cit16","doi-asserted-by":"publisher","first-page":"3350","DOI":"10.1039\/D3CS00698K","article-title":"Recent advances\nin super-resolution optical imaging based on aggregation-induced emission","volume":"53","author":"Zhu","year":"2024","journal-title":"Chem. Soc. Rev."},{"key":"2026100608073466900_cit17","doi-asserted-by":"publisher","first-page":"25705","DOI":"10.1021\/jacs.3c09058","article-title":"Adding Flying Wings:\nButterfly-Shaped NIR-II AIEgens with Multiple Molecular Rotors for\nPhotothermal Combating of Bacterial Biofilms","volume":"145","author":"Yan","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"8","key":"2026100608073466900_cit18","doi-asserted-by":"publisher","first-page":"nwaf254","DOI":"10.1093\/nsr\/nwaf254","article-title":"Unveiling photophysical\nmechanisms of NIR-II AIE luminogens for multimodal imaging-navigated\nsynergistic therapies","volume":"12","author":"Zhu","year":"2025","journal-title":"Nat. Sci. Rev."},{"issue":"6","key":"2026100608073466900_cit19","doi-asserted-by":"publisher","first-page":"2414976","DOI":"10.1002\/adfm.202414976","article-title":"Near-Infrared II AIE Luminogens with\nMitochondria-Targeting Characteristics for Combinational Phototherapies\nof Breast Tumors Through Synergistic Cell Apoptosis and Pyroptosis","volume":"35","author":"Su","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"2026100608073466900_cit20","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1021\/acsnano.5c16882","article-title":"Alkyl Chain Engineering\nfor High-Brightness Near-Infrared-II Aggregation-Induced Emission\nNanoprobes toward High-Resolution In Vivo Bioimaging","volume":"20","author":"Ren","year":"2026","journal-title":"ACS Nano"},{"issue":"1","key":"2026100608073466900_cit21","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1038\/s41467-024-46853-0","article-title":"Ultra-photostable\nsmall-molecule dyes facilitate near-infrared biophotonics","volume":"15","author":"Yan","year":"2024","journal-title":"Nat. Commun."},{"key":"2026100608073466900_cit22","doi-asserted-by":"publisher","first-page":"10177","DOI":"10.1021\/acsnano.6c01125","article-title":"Reconfigurable Mechanically Interlocked\nMetal-Organic Nanocages for Adaptive Guest Recognition and Allosteric\nRegulation","volume":"20","author":"Wu","year":"2026","journal-title":"ACS Nano"},{"issue":"3","key":"2026100608073466900_cit23","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.330","article-title":"An overview\non AIEgen-decorated porphyrins: Current\nstatus and applications","volume":"4","author":"Bodedla","year":"2023","journal-title":"Aggregate"},{"issue":"14","key":"2026100608073466900_cit24","doi-asserted-by":"publisher","first-page":"2309748","DOI":"10.1002\/adma.202309748","article-title":"An NIR-II excitable AIE small molecule with multimodal phototheranostic\nfeatures for orthotopic breast cancer treatment","volume":"36","author":"Song","year":"2024","journal-title":"Adv. Mater."},{"key":"2026100608073466900_cit25","doi-asserted-by":"publisher","first-page":"123799","DOI":"10.1016\/j.biomaterials.2025.123799","article-title":"Burning windjammer:\nMulti-rotor engineered photothermal agent with 87% photothermal conversion\nfor antimicrobial treatment","volume":"328","author":"Yang","year":"2026","journal-title":"Biomaterials"},{"issue":"6","key":"2026100608073466900_cit26","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202514722","article-title":"Unimolecular Micellization Strategy for Achieving NIR-II\nExcited Fluorophores with Enhanced Brightness in Aqueous Media","volume":"65","author":"Li","year":"2026","journal-title":"Angew. Chem., Int. Ed."},{"issue":"1","key":"2026100608073466900_cit27","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/s12951-025-03282-5","article-title":"Rationally\ndesigned NIR-II excitable and endoplasmic reticulum-targeted molecular\nphototheranostics for imaging-guided enhanced photoimmunotherapy of\ntriple-negative breast cancer","volume":"23","author":"Liu","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"36","key":"2026100608073466900_cit28","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304104","article-title":"Trisulfide Bond-Mediated\nMolecular Phototheranostic Platform for \u201cActivatable\u201d\nNIR-II Imaging-Guided Enhanced Gas\/Chemo-Hypothermal Photothermal\nTherapy","volume":"10","author":"Wu","year":"2023","journal-title":"Adv. Sci."},{"key":"2026100608073466900_cit29","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1021\/jacs.7b10334","article-title":"Donor Engineering\nfor NIR-II Molecular\nFluorophores with Enhanced Fluorescent Performance","volume":"140","author":"Yang","year":"2018","journal-title":"J. Am. Chem. Soc."},{"issue":"24","key":"2026100608073466900_cit30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2503574122","article-title":"Dual-laser\n\u201c808 and 1,064 nm\u201d strategy that circumvents the Achilles\u2019\nheel of photothermal therapy","volume":"122","author":"Ding","year":"2025","journal-title":"Proc. Natl. Acad.\nSci. U. S. A."},{"issue":"1","key":"2026100608073466900_cit31","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1186\/s12951-022-01679-0","article-title":"A mitochondria-targeted molecular\nphototheranostic platform for NIR-II imaging-guided synergistic photothermal\/photodynamic\/immune\ntherapy","volume":"20","author":"Yang","year":"2022","journal-title":"J. Nanobiotechnol."}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.6c02694","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/39\/28798\/68645305\/acs.analchem.6c02694.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/39\/28798\/68645305\/acs.analchem.6c02694.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:49:34Z","timestamp":1791290974000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancham\/article\/98\/39\/28798\/5438050\/Cross-Rotor-Coassembly-of-AIEgens-for-Dual-NIR-II"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":31,"journal-issue":{"issue":"39","published-online":{"date-parts":[[2026,9,24]]},"published-print":{"date-parts":[[2026,10,6]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.6c02694","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]}}}