{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:16:13Z","timestamp":1788218173543,"version":"build-2803163510"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["951459"],"award-info":[{"award-number":["951459"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["184.035.002"],"award-info":[{"award-number":["184.035.002"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Because of its low cost and portability, benchtop NMR has become increasingly popular over the last years. However, these low-field instruments lack sensitivity and spectral resolution, which limits their application in real-world problems, particularly at low concentrations. Here, we combine SABRE hyperpolarization with two-dimensional NMR spectroscopy on a benchtop spectrometer to gain sensitivity and spectral resolution. We employ a novel cosubstrate approach, utilizing an \u03b1-amino acid, which facilitates measurements at low micromolar concentrations. This approach enabled the complete resolution of a mixture of six N-heteroaromatic compounds at concentrations of 5 \u03bcM each, within 20 min. The power of this methodology was further tested on an extract of ground coffee, for which several analytes \u2013 estimated in the low micromolar concentration range \u2013 were identified.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c02720","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:01:59Z","timestamp":1786611719000},"page":"24340-24346","source":"Crossref","is-referenced-by-count":0,"title":["Mixture Analysis\nat Micromolar Concentrations with\n2D Benchtop NMR Enhanced by SABRE Hyperpolarization"],"prefix":"10.1021","volume":"98","author":[{"given":"Bono O.","family":"Jimmink","sequence":"first","affiliation":[{"name":"Radboud University , , Heyendaalseweg 135 , ,","place":["Nijmegen, The Netherlands, 6525 AJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9720-7718","authenticated-orcid":true,"given":"Mattia","family":"Negroni","sequence":"additional","affiliation":[{"name":"Radboud University , , Heyendaalseweg 135 , ,","place":["Nijmegen, The Netherlands, 6525 AJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3237-072X","authenticated-orcid":true,"given":"Thom B.","family":"Posthumus","sequence":"additional","affiliation":[{"name":"Radboud University , , Heyendaalseweg 135 , ,","place":["Nijmegen, The Netherlands, 6525 AJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5893-4488","authenticated-orcid":true,"given":"Arno P.M.","family":"Kentgens","sequence":"additional","affiliation":[{"name":"Radboud University , , Heyendaalseweg 135 , ,","place":["Nijmegen, The Netherlands, 6525 AJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8793-0072","authenticated-orcid":true,"given":"Marco","family":"Tessari","sequence":"additional","affiliation":[{"name":"Radboud University , , Heyendaalseweg 135 , ,","place":["Nijmegen, The Netherlands, 6525 AJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"2026083118453091400_cit1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780198556473.001.0001","volume-title":"Principles of Nuclear\nMagnetic Resonance in One and Two Dimensions","author":"Ernst","year":"1990"},{"issue":"1","key":"2026083118453091400_cit2","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1002\/pca.2921","article-title":"Low-field Benchtop NMR Spectroscopy: Status and Prospects\nin Natural Product Analysis\u2020","volume":"32","author":"Van Beek","year":"2021","journal-title":"Phytochem. Anal."},{"issue":"5","key":"2026083118453091400_cit3","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3390\/metabo13050614","article-title":"Benchtop NMR-Based Metabolomics:\nFirst Steps for Biomedical Application","volume":"13","author":"Alonso-Moreno","year":"2023","journal-title":"Metabolites"},{"issue":"9","key":"2026083118453091400_cit4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3390\/magnetochemistry7090121","article-title":"Recent Applications\nof Benchtop Nuclear\nMagnetic Resonance Spectroscopy","volume":"7","author":"Yu","year":"2021","journal-title":"Magnetochemistry"},{"key":"2026083118453091400_cit5","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.foodchem.2017.10.016","article-title":"High-Throughput\nAuthentication of Edible Oils with Benchtop Ultrafast 2D NMR","volume":"244","author":"Gouilleux","year":"2018","journal-title":"Food Chem."},{"issue":"2\u20133","key":"2026083118453091400_cit6","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/mrc.4816","article-title":"Practical\nApplication of 1H Benchtop NMR\nSpectroscopy for the Characterization of a Nonaqueous Phase Liquid\nfrom a Contaminated Environment","volume":"57","author":"Fallaise","year":"2019","journal-title":"Magn. Reson.\nChem."},{"issue":"4","key":"2026083118453091400_cit7","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3390\/metabo10040155","article-title":"Benchtop Low-Frequency 60 MHz NMR Analysis of Urine:\nA Comparative Metabolomics Investigation","volume":"10","author":"Leenders","year":"2020","journal-title":"Metabolites"},{"key":"2026083118453091400_cit8","doi-asserted-by":"publisher","first-page":"100194","DOI":"10.1016\/j.jmro.2025.100194","article-title":"Robotic Arms for\nHyperpolarization-Enhanced NMR","volume":"23","author":"Sheberstov","year":"2025","journal-title":"NJ. Magn. Reson.\nOpen"},{"issue":"2","key":"2026083118453091400_cit9","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/mrc.5197","article-title":"Benchtop Nuclear\nMagnetic Resonance Spectroscopy in\nForensic Chemistry","volume":"61","author":"Draper","year":"2023","journal-title":"Magn. Reson. Chem."},{"key":"2026083118453091400_cit10","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.trac.2016.05.004","article-title":"Perspectives\nfor Hyperpolarisation in Compact NMR","volume":"83","author":"Halse","year":"2016","journal-title":"TrAC,\nTrends Anal. Chem."},{"key":"2026083118453091400_cit11","doi-asserted-by":"publisher","first-page":"2400094","DOI":"10.1002\/cmtd.202400094","article-title":"Low-Micromolar Quantification of\nFluorinated Analytes Using Hyperpolarized 19F Benchtop\nNuclear Magnetic Resonance","volume":"5","author":"Silva Terra","year":"2025","journal-title":"Chem.: Methods"},{"issue":"10","key":"2026083118453091400_cit12","doi-asserted-by":"publisher","first-page":"6695","DOI":"10.1021\/acs.analchem.9b00729","article-title":"Reaction\nMonitoring Using SABRE-Hyperpolarized Benchtop\n(1 T) NMR Spectroscopy","volume":"91","author":"Semenova","year":"2019","journal-title":"Anal. Chem."},{"issue":"12","key":"2026083118453091400_cit13","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1002\/mrc.4999","article-title":"Benchtop NMR Analysis of Piperazine-based Drugs Hyperpolarised\nby SABRE","volume":"58","author":"Tennant","year":"2020","journal-title":"Magn. Reson. Chem."},{"issue":"1","key":"2026083118453091400_cit14","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1021\/jacs.3c10030","article-title":"In Situ Hyperpolarization Enables 15N and 13C Benchtop NMR at Natural Isotopic Abundance","volume":"146","author":"Kircher","year":"2024","journal-title":"J. Am. Chem. Soc."},{"issue":"14","key":"2026083118453091400_cit15","doi-asserted-by":"publisher","first-page":"3442","DOI":"10.1039\/C8AN00596F","article-title":"SABRE Hyperpolarization\nEnables High-Sensitivity 1H and 13C Benchtop\nNMR Spectroscopy","volume":"143","author":"Richardson","year":"2018","journal-title":"Analyst"},{"issue":"69","key":"2026083118453091400_cit16","doi-asserted-by":"publisher","first-page":"12992","DOI":"10.1039\/D5CC02870A","article-title":"Detection and resolution of sub-millimolar\nconcentration amino acids\non a benchtop NMR spectrometer by nh-PHIP hyperpolarization","volume":"61","author":"Urban\u0301czyk","year":"2025","journal-title":"Chem. Commun."},{"issue":"21","key":"2026083118453091400_cit17","doi-asserted-by":"publisher","first-page":"10962","DOI":"10.1021\/acs.analchem.5c01026","article-title":"Quantitative\nTrace Analysis of Dilute Mixtures Using a Benchtop NMR System with\nSABRE Hyperpolarization","volume":"97","author":"Jimmink","year":"2025","journal-title":"Anal. Chem."},{"key":"2026083118453091400_cit18","doi-asserted-by":"publisher","first-page":"16133","DOI":"10.1021\/acs.analchem.5c00040","article-title":"Quantitative\nDetection of Pyrazines in Edible Oils Using SABRE Hyperpolarized\nNMR Spectroscopy","volume":"97","author":"Dai","year":"2025","journal-title":"Anal. Chem."},{"issue":"37","key":"2026083118453091400_cit19","doi-asserted-by":"publisher","first-page":"13362","DOI":"10.1021\/ja903601p","article-title":"Spontaneous Transfer\nof Para Hydrogen Derived Spin Order to Pyridine at\nLow Magnetic Field","volume":"131","author":"Atkinson","year":"2009","journal-title":"J. Am. Chem. Soc."},{"issue":"5922","key":"2026083118453091400_cit20","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1126\/science.1168877","article-title":"Reversible\nInteractions with Para-Hydrogen Enhance\nNMR Sensitivity by Polarization Transfer","volume":"323","author":"Adams","year":"2009","journal-title":"Science"},{"issue":"1","key":"2026083118453091400_cit21","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1039\/C5CP05134G","article-title":"A Simple\nAnalytical Model for Signal Amplification by Reversible Exchange (SABRE)\nProcess","volume":"18","author":"Barskiy","year":"2016","journal-title":"Phys. Chem. Chem. Phys."},{"key":"2026083118453091400_cit22","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.pnmrs.2019.05.005","article-title":"SABRE: Chemical\nKinetics and Spin Dynamics of the Formation of Hyperpolarization","volume":"114\u2013115","author":"Barskiy","year":"2019","journal-title":"Prog. Nucl. Magn. Reson. Spectrosc."},{"issue":"7","key":"2026083118453091400_cit23","doi-asserted-by":"publisher","first-page":"2695","DOI":"10.1021\/ja412994k","article-title":"Toward Nanomolar Detection\nby NMR Through SABRE Hyperpolarization","volume":"136","author":"Eshuis","year":"2014","journal-title":"J. Am.\nChem. Soc."},{"issue":"5","key":"2026083118453091400_cit24","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1002\/ange.201409795","article-title":"Quantitative Trace Analysis of Complex\nMixtures Using SABRE Hyperpolarization","volume":"127","author":"Eshuis","year":"2015","journal-title":"Angew.\nChem."},{"issue":"10","key":"2026083118453091400_cit25","doi-asserted-by":"publisher","first-page":"3342","DOI":"10.1039\/D5CC06186E","article-title":"Benchtop NMR Signal Enhancement of\nMetabolites in Urine Extract Using SABRE","volume":"62","author":"Fleischer","year":"2026","journal-title":"Chem.\nCommun."},{"issue":"16","key":"2026083118453091400_cit26","doi-asserted-by":"publisher","first-page":"3413","DOI":"10.1002\/cphc.201500535","article-title":"Single-Scan\nMultidimensional NMR Analysis of Mixtures at Sub-Millimolar Concentrations\nby Using SABRE Hyperpolarization","volume":"16","author":"Daniele","year":"2015","journal-title":"ChemPhyschem"},{"issue":"31","key":"2026083118453091400_cit27","doi-asserted-by":"publisher","first-page":"12904","DOI":"10.1021\/ja3051052","article-title":"Utilization\nof SABRE-Derived Hyperpolarization To Detect Low-Concentration Analytes\nvia 1D and 2D NMR Methods","volume":"134","author":"Lloyd","year":"2012","journal-title":"J. Am. Chem. Soc."},{"issue":"2","key":"2026083118453091400_cit28","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/0022-2364(85)90018-6","article-title":"MLEV-17-Based Two-Dimensional\nHomonuclear Magnetization\nTransfer Spectroscopy","volume":"65","author":"Bax","year":"1985","journal-title":"J. Magn. Reson."},{"issue":"3","key":"2026083118453091400_cit29","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/0022-2364(83)90226-3","article-title":"Coherence Transfer by Isotropic Mixing: Application\nto Proton Correlation Spectroscopy","volume":"53","author":"Braunschweiler","year":"1983","journal-title":"J. Magn.\nReson."},{"key":"2026083118453091400_cit30","volume-title":"Coffee Flavor\nChemistry","author":"Flament","year":"2002"},{"key":"2026083118453091400_cit31","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jmr.2019.02.006","article-title":"ssNake: A Cross-Platform\nOpen-Source NMR Data Processing and Fitting Application","volume":"301","author":"Van Meerten","year":"2019","journal-title":"J. Magn. Reson."},{"key":"2026083118453091400_cit32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0066-4103(08)60264-1","article-title":"Sensitivity-Enhanced NMR Techniques\nfor the Study of Biomolecules","volume":"27","author":"Cavanagh","year":"1993","journal-title":"Annu. Rep. NMR\nSpectrosc."},{"issue":"1","key":"2026083118453091400_cit33","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0022-2364(79)90088-X","article-title":"Homonuclear\nBroadband-Decoupled Absorption\nSpectra, with Linewidths Which Are Independent of the Transverse Relaxation\nRate","volume":"35","author":"Bax","year":"1979","journal-title":"J. Magn. Reson."},{"issue":"2","key":"2026083118453091400_cit34","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/0022-2364(81)90045-7","article-title":"A Simple\nMethod for Suppressing Dispersion-Mode\nContributions in NMR Spectra: The \u201cPseudo Echo","volume":"43","author":"Bax","year":"1981","journal-title":"J. Magn. Reson."},{"issue":"2","key":"2026083118453091400_cit35","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1080\/00268978900102331","article-title":"Broadband Homonuclear\nCross Polarization in 2D N.M.R.\nUsing DIPSI-2","volume":"68","author":"Rucker","year":"1989","journal-title":"Mol. Phys."},{"issue":"3","key":"2026083118453091400_cit36","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/BF00197809","article-title":"NMRPipe: A Multidimensional Spectral\nProcessing System Based on UNIX\nPipes","volume":"6","author":"Delaglio","year":"1995","journal-title":"J. Biomol. NMR"},{"issue":"8","key":"2026083118453091400_cit37","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/mrc.5355","article-title":"A Robust t1 Noise Suppression Method in NMR Spectroscopy","volume":"61","author":"Wei","year":"2023","journal-title":"Magn. Reson. Chem."},{"issue":"52","key":"2026083118453091400_cit38","doi-asserted-by":"publisher","first-page":"27160","DOI":"10.1002\/ange.202109588","article-title":"Parahydrogen Hyperpolarization\nAllows Direct NMR Detection\nof \u03b1-Amino Acids in Complex (Bio)Mixtures","volume":"133","author":"Sellies","year":"2021","journal-title":"Angew. Chem."},{"issue":"25","key":"2026083118453091400_cit39","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.202300260","article-title":"Computational\n(DFT) and Experimental\n(NMR) Study of the Chelation of an Iridium Hyperpolarization Transfer\nCatalyst by Amino Acids","volume":"26","author":"Bouma","year":"2023","journal-title":"Eur. J. Inorg. Chem."},{"issue":"3","key":"2026083118453091400_cit40","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1021\/jacs.2c11285","article-title":"NMR Discrimination\nof D - and L -\u03b1-Amino Acids at Submicromolar Concentration via\nParahydrogen-Induced Hyperpolarization","volume":"145","author":"Dreisewerd","year":"2023","journal-title":"J. Am.\nChem. Soc."},{"issue":"30","key":"2026083118453091400_cit41","doi-asserted-by":"publisher","first-page":"10271","DOI":"10.1002\/anie.201905483","article-title":"Hyperpolarising Pyruvate through Signal Amplification\nby Reversible Exchange (SABRE)","volume":"58","author":"Iali","year":"2019","journal-title":"Angew. Chem.\nInt. Ed."},{"issue":"3","key":"2026083118453091400_cit42","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1021\/acs.analchem.5c05273","article-title":"SABRE Acethydrazide as a Co-Substrate\nAgent for Quantitative Analysis of Submicromolar N-Heterocyclic Compounds\nUsing Parahydrogen Hyperpolarization","volume":"98","author":"Luu","year":"2026","journal-title":"Anal.\nChem."},{"issue":"1","key":"2026083118453091400_cit43","doi-asserted-by":"publisher","first-page":"4251","DOI":"10.1038\/s41467-018-06766-1","article-title":"Fine-Tuning\nthe\nEfficiency of Para-Hydrogen-Induced Hyperpolarization by Rational\nN-Heterocyclic Carbene Design","volume":"9","author":"Rayner","year":"2018","journal-title":"Nat. Commun."},{"issue":"23","key":"2026083118453091400_cit44","doi-asserted-by":"publisher","first-page":"13453","DOI":"10.1021\/ic401783c","article-title":"(III) Hydrido N-Heterocyclic\nCarbene\u2013Phosphine Complexes as Catalysts in Magnetization Transfer\nReactions","volume":"52","author":"Fekete","year":"2013","journal-title":"Inorg. Chem."},{"issue":"16","key":"2026083118453091400_cit45","doi-asserted-by":"publisher","first-page":"1620457114","DOI":"10.1073\/pnas.1620457114","article-title":"Delivering\nStrong1 H Nuclear Hyperpolarization Levels and Long Magnetic\nLifetimes through Signal Amplification by Reversible Exchange","volume":"114","author":"Rayner","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"2026083118453091400_cit46","doi-asserted-by":"publisher","first-page":"3544","DOI":"10.1039\/C4CY00464G","article-title":"Hyperpolarisation\nThrough Reversible Interactions With\nParahydrogen","volume":"4","author":"Lloyd","year":"2014","journal-title":"Catal. Sci. Technol."},{"key":"2026083118453091400_cit47","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1039\/b715938b","article-title":"Highly Active Iridium(i)\nComplexes for Catalytic Hydrogen\nIsotope Exchange","volume":"9","author":"Brown","year":"2008","journal-title":"Chem. Commun."},{"issue":"9","key":"2026083118453091400_cit48","doi-asserted-by":"publisher","first-page":"3322","DOI":"10.1021\/ja501052p","article-title":"The Feasibility\nof Formation and Kinetics of NMR Signal Amplification by Reversible\nExchange (SABRE) at High Magnetic Field (9.4 T)","volume":"136","author":"Barskiy","year":"2014","journal-title":"J. Am. Chem. Soc."},{"issue":"16","key":"2026083118453091400_cit49","doi-asserted-by":"publisher","first-page":"6134","DOI":"10.1021\/ja200299u","article-title":"Iridium N-Heterocyclic\nCarbene Complexes\nas Efficient Catalysts for Magnetization Transfer from Para -Hydrogen","volume":"133","author":"Cowley","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"2026083118453091400_cit50","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jmr.2015.10.006","article-title":"Spin Polarization Transfer Mechanisms\nof SABRE: A Magnetic Field Dependent Study","volume":"261","author":"Pravdivtsev","year":"2015","journal-title":"J. Magn. Reson."},{"issue":"29","key":"2026083118453091400_cit51","doi-asserted-by":"publisher","first-page":"24470","DOI":"10.1039\/C5RA28059A","article-title":"Quantitative Description of the SABRE\nProcess: Rigorous\nConsideration of Spin Dynamics and Chemical Exchange","volume":"6","author":"Knecht","year":"2016","journal-title":"RSC Adv."},{"key":"2026083118453091400_cit52","doi-asserted-by":"publisher","first-page":"100172","DOI":"10.1016\/j.jmro.2024.100172","article-title":"Hyperpolarization and\nSensitivity in Nuclear Magnetic Resonance","volume":"21","author":"Kour\u030cil","year":"2024","journal-title":"NJ.\nMagn. Reson. Open"},{"key":"2026083118453091400_cit53","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.foodres.2018.03.077","article-title":"Variability of Single\nBean Coffee Volatile Compounds of Arabica and Robusta Roasted Coffees\nAnalysed by SPME-GC-MS","volume":"108","author":"Caporaso","year":"2018","journal-title":"Food Res. Int."},{"issue":"6","key":"2026083118453091400_cit54","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.3390\/foods10061347","article-title":"Analysis of Volatile\nCompounds in Coffee Prepared by Various Brewing and Roasting Methods","volume":"10","author":"Yu","year":"2021","journal-title":"Foods"},{"issue":"6","key":"2026083118453091400_cit55","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1021\/acs.analchem.6b00184","article-title":"NMR-Based Chemosensing\nvia p -H2 Hyperpolarization: Application\nto Natural Extracts","volume":"88","author":"Hermkens","year":"2016","journal-title":"Anal. Chem."},{"issue":"2","key":"2026083118453091400_cit56","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3136\/fstr.12.148","article-title":"A Radical Scavenging Compound, 3-Pyridinol, in Instant\nCoffee and Its Hepatoprotective Activity","volume":"12","author":"Kurakane","year":"2006","journal-title":"FSTR"},{"issue":"16","key":"2026083118453091400_cit57","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1039\/D5AY00006H","article-title":"Evaluation of Pure Shift NMR Methods for the Analysis\nof Complex Metabolite Mixtures with a Benchtop NMR Spectrometer","volume":"17","author":"Mandral","year":"2025","journal-title":"Anal. Methods"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.6c02720","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/33\/24340\/66521959\/acs.analchem.6c02720.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/33\/24340\/66521959\/acs.analchem.6c02720.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:45:38Z","timestamp":1788216338000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancham\/article\/98\/33\/24340\/5254090\/Mixture-Analysis-at-Micromolar-Concentrations-with"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":57,"journal-issue":{"issue":"33","published-online":{"date-parts":[[2026,8,13]]},"published-print":{"date-parts":[[2026,8,25]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.6c02720","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]}}}