{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:18:30Z","timestamp":1788434310624,"version":"build-2803163510"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"34","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22231001"],"award-info":[{"award-number":["22231001"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22301017"],"award-info":[{"award-number":["22301017"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22477009"],"award-info":[{"award-number":["22477009"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Organic fluorophores operating in the second near-infrared window (NIR-II, 900\u20131700 nm) are plagued by low quantum yields (QYs) and diminished brightness in aqueous media. To address this challenge, we proposed a strategy of regulating the activation energy for aggregates transformation to achieve high-brightness NIR-II J-aggregates. Three aza-boron-dipyrromethene (aza-BODIPY) with heterocyclic substituents were synthesized. Among them compound ABS with substituents of dibenzothiophene exhibited the strongest J-aggregation propensity, as evidenced by aggregation kinetics studies. The self-assembly properties in water were modulated by grafting hydrophilic and hydrophobic chains onto the ABS core. This molecular engineering strategy promoted exciton delocalization and accelerated radiative decay (kr = 0.191 ns\u20131) for NIR-II J-aggregates of ABS-2 in water, achieving a record-high absolute quantum yield of 10.11%. Coupled with a molar extinction coefficient of 1.6 \u00d7 105 M\u20131\u00b7cm\u20131, the ABS-2 J-aggregates demonstrated ultrahigh brightness (B = 1.6 \u00d7 104 M\u20131\u00b7cm\u20131), surpassing most aqueous NIR-II emitters. Leveraging these photophysical merits, ABS-2 J-aggregates enabled NIR-II fluorescence imaging of blood vessels and also allowed NIR-II fluorescence and photoacoustic imaging of tumors in mice, showcasing its dual-modal diagnostic potential. We anticipate that the proposed strategy of regulating the activation energy for aggregates transformation may inspire further research for design of NIR-II fluorophores with high quantum yield and brightness, to improve the spatial resolution and tissue penetration depth of in vivo fluorescence imaging.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c02737","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:01:50Z","timestamp":1786964510000},"page":"25022-25030","source":"Crossref","is-referenced-by-count":0,"title":["Facilitating\nJ-Aggregate Formation by Lowering\nActivation Energy to Achieve Ultrahigh Brightness for NIR-II Fluorescence\nImaging and Photoacoustic Imaging"],"prefix":"10.1021","volume":"98","author":[{"given":"Jie","family":"Li","sequence":"first","affiliation":[{"name":"Beijing Normal University , , ,","place":["Beijing, P. R. China, 100875"]},{"name":"National Institute of Metrology , , ,","place":["Beijing, P. R. 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China, 230026"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3826-5579","authenticated-orcid":true,"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China , , , ,","place":["Hefei, Anhui, P. R. China, 230026"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5376-6902","authenticated-orcid":true,"given":"Li-Ya","family":"Niu","sequence":"additional","affiliation":[{"name":"Beijing Normal University , , ,","place":["Beijing, P. R. China, 100875"]},{"name":"Beijing Key Laboratory of Innovative and Transformable Warning and Intervention Technologies for Drug-Resistant Pathogens , ,","place":["Beijing, P. R. China, 100871"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9131-4907","authenticated-orcid":true,"given":"Qing-Zheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Normal University , , ,","place":["Beijing, P. R. China, 100875"]},{"name":"Beijing Key Laboratory of Innovative and Transformable Warning and Intervention Technologies for Drug-Resistant Pathogens , ,","place":["Beijing, P. R. China, 100871"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"2026090306444695800_cit1","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/nnano.2009.326","article-title":"Second window for in vivo imaging","volume":"4","author":"Smith","year":"2009","journal-title":"Nat. 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