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However, precise monitoring of such redox disorders under environmental stress remains largely underexplored, limiting understanding of stress-induced physiological disorders and related toxicological mechanisms. Herein, two Cys-activated fluorescent probes featuring furan and thiophene \u03c0-bridge modifications, Afd-Cys and Atd-Cys, were designed to evaluate redox imbalance induced by thiol-chelating pollutants (Cd2+\/Hg2+) and nonthiol-chelating stress (high salt, glucose, and poly(methyl methacrylate)). Two probes show large Stokes shifts (129 and 138 nm) and high sensitivity (LOD = 32.8 and 56.6 nM). Afd-Cys exhibits more distinct changes in fluorescence quantum yield and lifetime, with its sensing mechanism verified by MS and DFT calculations. Furthermore, Afd-Cys enables Cys imaging under exogenous stimulation in multiple cell lines. It was also applied to monitor redox imbalance fluctuations in HepG2 cells, cockscomb flowers, and zebrafish under diverse environmental exposures, revealing corresponding redox responses, and elucidate the molecular mechanisms underlying redox imbalance induced by thiol-chelating environmental stress. This work provides original insights for Cys-mediated redox imbalance under typical environmental stress.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c02837","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:23:55Z","timestamp":1783733035000},"page":"21751-21761","source":"Crossref","is-referenced-by-count":1,"title":["Visualization\nof Cysteine-Mediated Redox Imbalance\nunder Environmental Exposures via \u03c0-Bridge-Tailored Fluorescent\nProbes"],"prefix":"10.1021","volume":"98","author":[{"given":"Jiangkun","family":"Tan","sequence":"first","affiliation":[{"name":"Chinese Academy of Sciences , , , ,","place":["Yantai, Shandong, China, 264003"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3032-3706","authenticated-orcid":true,"given":"Yixuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , , ,","place":["Yantai, Shandong, China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Qufu Normal University , , , ,","place":["Qufu, Shandong, China, 273165"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1499-8759","authenticated-orcid":true,"given":"Zan","family":"Li","sequence":"additional","affiliation":[{"name":"Qufu Normal University , , , ,","place":["Qufu, Shandong, China, 273165"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Shaoxing University , , , ,","place":["Shaoxing, Zhejiang, China, 312000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Medical and Pharmaceutical University , , , ,","place":["Yantai, Shandong, China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[{"name":"Shaoxing University , , , ,","place":["Shaoxing, Zhejiang, China, 312000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5317-0087","authenticated-orcid":true,"given":"Liangwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , , ,","place":["Yantai, Shandong, China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8808-6085","authenticated-orcid":true,"given":"Jinmao","family":"You","sequence":"additional","affiliation":[{"name":"Shaoxing University , , , ,","place":["Shaoxing, Zhejiang, China, 312000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3764-3515","authenticated-orcid":true,"given":"Lingxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , , ,","place":["Yantai, Shandong, China, 264003"]},{"name":"Shaoxing University , , , ,","place":["Shaoxing, Zhejiang, China, 312000"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"2026072808080485000_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2023.117461","article-title":"Recent process\nin organic small molecular fluorescent probes for tracking markers\nof tumor redox balance","volume":"170","author":"Wu","year":"2024","journal-title":"TrAC-Trend. 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