{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:48:23Z","timestamp":1785847703893,"version":"3.56.0"},"reference-count":65,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Guangxi Science and Technology Program","award":["GUIKE AD25069038"],"award-info":[{"award-number":["GUIKE AD25069038"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["22376040"],"award-info":[{"award-number":["22376040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["22466008"],"award-info":[{"award-number":["22466008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As an emerging form of regulated cell death, ferroptosis has been identified as a key contributor to the pathogenesis of several diseases. Superoxide anion (O2\u2022\u2013), a key reactive oxygen species, is closely associated with ferroptosis-mediated acute liver injury (ALI). The development of in situ, real-time imaging tools capable of visualizing O2\u2022\u2013 will benefit the early diagnosis and therapeutic intervention of ferroptosis-mediated ALI. In this work, we designed and synthesized a photoacoustic (PA) probe, Rho-DOH, based on a rhodamine scaffold, for the specific detection of O2\u2022\u2013. Rho-DOH exhibits a highly sensitive, selective, and fast PA response toward O2\u2022\u2013, characterized by a large bathochromic shift of 125 nm and an activation fold of up to 29-fold. Cellular experiments demonstrate that Rho-DOH enables high-contrast PA imaging of endogenous O2\u2022\u2013 in cells. Moreover, Rho-DOH was successfully applied to detect the ferroptosis-mediated ALI and to evaluate therapeutic responses through its O2\u2022\u2013-responsive PA imaging signal. These findings position Rho-DOH as a promising molecular imaging tool, offering robust support for the accurate diagnosis and treatment of ferroptosis-associated liver injury.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c02848","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T05:52:06Z","timestamp":1784526726000},"page":"22418-22428","source":"Crossref","is-referenced-by-count":0,"title":["Photoacoustic\nProbe for Rapidly Recognizing Superoxide\nAnion Affording Visualized Tracing of Ferroptosis-Mediated Acute Liver\nInjury"],"prefix":"10.1021","volume":"98","author":[{"given":"Yidong","family":"Bin","sequence":"first","affiliation":[{"name":"Guangxi Normal University , , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixian","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangxi Normal University , , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiying","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Normal University , , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guangxi Normal University , , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4699-4381","authenticated-orcid":true,"given":"Shengqiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Guangxi Normal University , , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2560-042X","authenticated-orcid":true,"given":"Shulin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guangxi Normal University , , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4270-9555","authenticated-orcid":true,"given":"Yong","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangxi Normal University , , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1108-8258","authenticated-orcid":true,"given":"Liangliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangxi Normal University , , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"issue":"5","key":"2026080408084936500_cit1","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis:\nAn iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"1","key":"2026080408084936500_cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01969-z","article-title":"Iron homeostasis\nand ferroptosis in human diseases: mechanisms and therapeutic prospects","volume":"9","author":"Ru","year":"2024","journal-title":"Signal Transduction Targeted Ther."},{"issue":"8","key":"2026080408084936500_cit3","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/s41583-025-00930-5","article-title":"Neuroferroptosis\nin health and diseases","volume":"26","author":"Lei","year":"2025","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"2026080408084936500_cit4","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology\nand role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026080408084936500_cit5","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1146\/annurev-pathmechdis-051122-094016","article-title":"Acetaminophen hepatotoxicity: paradigm for understanding\nmechanisms of drug-induced liver injury","volume":"19","author":"Jaeschke","year":"2024","journal-title":"Annu.\nRev. Pathol."},{"issue":"3","key":"2026080408084936500_cit6","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41418-022-00941-0","article-title":"The multifaceted role\nof ferroptosis in liver disease","volume":"29","author":"Chen","year":"2022","journal-title":"Cell Death\nDiffer."},{"issue":"11","key":"2026080408084936500_cit7","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s00109-025-02599-w","article-title":"Involvement of ferroptosis\nin metabolic dysfunction-associated steatohepatitis-related liver\ndiseases","volume":"103","author":"Liu","year":"2025","journal-title":"J. Mol. Med."},{"issue":"1","key":"2026080408084936500_cit8","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3109\/03602532.2011.602688","article-title":"Oxidant stress,\nmitochondria, and\ncell death mechanisms in drug-induced liver injury: Lessons learned\nfrom acetaminophen hepatotoxicity","volume":"44","author":"Jaeschke","year":"2012","journal-title":"Drug Metab.\nRev."},{"issue":"1","key":"2026080408084936500_cit9","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jhep.2011.01.006","article-title":"Reactive oxygen species in the normal\nand acutely injured\nliver","volume":"55","author":"Jaeschke","year":"2011","journal-title":"J. Hepatol."},{"issue":"3","key":"2026080408084936500_cit10","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3390\/antiox13030298","article-title":"Antioxidant\nsystems as modulators of ferroptosis: focus on transcription factors","volume":"13","author":"Punziano","year":"2024","journal-title":"Antioxidants"},{"issue":"6","key":"2026080408084936500_cit11","doi-asserted-by":"publisher","first-page":"564","DOI":"10.3390\/metabo12060564","article-title":"The potential role of metabolomics\nin drug-induced liver injury (DILI) Assessment","volume":"12","author":"Moreno-Torres","year":"2022","journal-title":"Metabolites"},{"issue":"11\u201312","key":"2026080408084936500_cit12","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1089\/neu.2022.0147","article-title":"Susceptibility to hepatotoxic drug-induced liver injury\nincreased after traumatic brain injury in mice","volume":"41","author":"Yuan","year":"2024","journal-title":"J. Neurotrauma"},{"issue":"2","key":"2026080408084936500_cit13","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1021\/acs.accounts.0c00646","article-title":"Design strategy\nof fluorescent probes for live drug-induced acute liver injury imaging","volume":"54","author":"Cheng","year":"2021","journal-title":"Acc. Chem. Res."},{"issue":"2","key":"2026080408084936500_cit14","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/hep.20548","article-title":"Serum alanine\naminotransferase in skeletal muscle diseases","volume":"41","author":"Nathwani","year":"2005","journal-title":"Hepatology"},{"issue":"5","key":"2026080408084936500_cit15","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/s41551-024-01286-4","article-title":"Magnetic-susceptibility-dependent\nratiometric probes for enhancing quantitative MRI","volume":"9","author":"Zhang","year":"2025","journal-title":"Nat. Biomed. Eng."},{"issue":"1","key":"2026080408084936500_cit16","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41563-024-02054-0","article-title":"Responsive probes for\nin vivo magnetic resonance imaging of nitric oxide","volume":"24","author":"Lu","year":"2025","journal-title":"Nat. Mater."},{"issue":"6","key":"2026080408084936500_cit17","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1038\/s41563-026-02507-8","article-title":"Radioisotope-mimetic\nmolecular afterglow probe for downregulated cancer biomarker imaging","volume":"25","author":"Zhang","year":"2026","journal-title":"Nat. Mater."},{"issue":"1","key":"2026080408084936500_cit18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1872-2040(13)60701-X","article-title":"Progress on\nElectrochemical Determination\nof Superoxide Anion","volume":"42","author":"Wang","year":"2014","journal-title":"Chin. J. Anal. Chem."},{"issue":"23","key":"2026080408084936500_cit19","doi-asserted-by":"publisher","first-page":"7269","DOI":"10.1073\/pnas.81.23.7269","article-title":"Detection of superoxide generated by endothelial cells","volume":"81","author":"Rosen","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"3","key":"2026080408084936500_cit20","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/j.1748-1716.1993.tb09498.x","article-title":"ESR-measurement of\noxygen radicals in vivo after renal ischaemia in the rabbit. Effects\nof pre-treatment with superoxide dismutase and heparin","volume":"147","author":"Nilsson","year":"1993","journal-title":"Acta Physiol. Scand."},{"issue":"5","key":"2026080408084936500_cit21","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1021\/cr960386p","article-title":"Signaling recognition events with fluorescent sensors\nand switches","volume":"97","author":"de Silva","year":"1997","journal-title":"Chem. Rev."},{"issue":"16","key":"2026080408084936500_cit22","doi-asserted-by":"publisher","first-page":"9225","DOI":"10.1021\/acs.chemrev.3c00892","article-title":"Ex Tenebris\nLux: illuminating reactive\noxygen and nitrogen species with small molecule probes","volume":"124","author":"Cabello","year":"2024","journal-title":"Chem. Rev."},{"issue":"11","key":"2026080408084936500_cit23","doi-asserted-by":"publisher","first-page":"7106","DOI":"10.1021\/acs.chemrev.3c00776","article-title":"Fluorescent\nprobes for disease diagnosis","volume":"124","author":"Wang","year":"2024","journal-title":"Chem. Rev."},{"key":"2026080408084936500_cit24","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.biomaterials.2017.11.039","article-title":"A mitochondrial-targeting\nnear-infrared fluorescent probe for bioimaging\nand evaluating endogenous superoxide anion changes during ischemia\/reperfusion\ninjury","volume":"156","author":"Han","year":"2018","journal-title":"Biomaterials"},{"issue":"11","key":"2026080408084936500_cit25","doi-asserted-by":"publisher","first-page":"3921","DOI":"10.1039\/D0SC05937D","article-title":"Fluorescent probe for the imaging\nof superoxide and peroxynitrite during drug-induced liver injury","volume":"12","author":"Wu","year":"2021","journal-title":"Chem. Sci."},{"issue":"36","key":"2026080408084936500_cit26","doi-asserted-by":"publisher","first-page":"12352","DOI":"10.1021\/acs.analchem.2c01317","article-title":"Quantitative\nfluorescence\nimaging of the intracellular redox state by real-time spatial and\ntemporal simultaneous analysis of O2\u2022\u2013 levels\nand keap1 translocation","volume":"94","author":"Zhang","year":"2022","journal-title":"Anal. Chem."},{"key":"2026080408084936500_cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.163580","article-title":"DPP dye-based ratiometric\nnanoprobe for visualization of ferroptosis-mediated acute\/chronic\nliver injury via imaging ONOO\u2013","volume":"515","author":"Wang","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"6","key":"2026080408084936500_cit28","doi-asserted-by":"publisher","first-page":"6148","DOI":"10.1021\/jacs.5c17084","article-title":"Early ferroptosis detection\ntargeting lipid hydrogen abstraction","volume":"148","author":"Li","year":"2026","journal-title":"J. Am.\nChem. Soc."},{"issue":"6","key":"2026080408084936500_cit29","doi-asserted-by":"publisher","first-page":"5159","DOI":"10.1021\/acs.analchem.6c00210","article-title":"A visible\/NIR-II dual-channel fluorescent\nprobe for investigating the roles of nlrp3 inflammasome and ferroptosis\nduring hepatic ischemia-reperfusion injury","volume":"98","author":"Chao","year":"2026","journal-title":"Anal. Chem."},{"issue":"6","key":"2026080408084936500_cit30","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201805875","article-title":"Photoacoustic\nimaging:\ncontrast agents and their biomedical applications","volume":"31","author":"Fu","year":"2019","journal-title":"Adv. Mater."},{"issue":"11","key":"2026080408084936500_cit31","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.1021\/acs.accounts.8b00351","article-title":"Acoustogenic Probes: A new frontier in photoacoustic imaging","volume":"51","author":"Knox","year":"2018","journal-title":"Acc. Chem. Res."},{"issue":"6","key":"2026080408084936500_cit32","doi-asserted-by":"publisher","first-page":"6850","DOI":"10.1021\/acs.chemrev.1c00875","article-title":"Chemical design\nof activatable photoacoustic probes for precise biomedical applications","volume":"122","author":"Liu","year":"2022","journal-title":"Chem. Rev."},{"issue":"11","key":"2026080408084936500_cit33","doi-asserted-by":"publisher","first-page":"7379","DOI":"10.1021\/acs.chemrev.2c00627","article-title":"Recent advances in contrast-enhanced\nphotoacoustic imaging: overcoming\nthe physical and practical challenges","volume":"123","author":"Choi","year":"2023","journal-title":"Chem.\nRev."},{"issue":"7","key":"2026080408084936500_cit34","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1039\/C8CS00618K","article-title":"Photothermal therapy\nand photoacoustic imaging via nanotheranostics in fighting cancer","volume":"48","author":"Liu","year":"2019","journal-title":"Chem. Soc. Rev."},{"issue":"3","key":"2026080408084936500_cit35","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1039\/D0CS00771D","article-title":"Targeted contrast agents and activatable\nprobes for photoacoustic imaging of cancer","volume":"51","author":"Zhao","year":"2022","journal-title":"Chem. Soc. Rev."},{"issue":"19","key":"2026080408084936500_cit36","doi-asserted-by":"publisher","first-page":"8809","DOI":"10.1039\/D5CS00745C","article-title":"Small-molecule photoacoustic\nprobes for in vivo imaging","volume":"54","author":"Wang","year":"2025","journal-title":"Chem. Soc. Rev."},{"issue":"16","key":"2026080408084936500_cit37","doi-asserted-by":"publisher","first-page":"6251","DOI":"10.1021\/acs.analchem.2c00041","article-title":"Mitochondria-targeted\nfluorescence\/photoacoustic dual-modality imaging\nprobe tailored for visual precise diagnosis of drug-induced liver\ninjury","volume":"94","author":"Zhang","year":"2022","journal-title":"Anal. Chem."},{"issue":"7","key":"2026080408084936500_cit38","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202418378","article-title":"fluorescence\/photoacoustic\ndual ratiometric probes with unique recognition site for quantitatively\nvisualizing H2S2 in vivo","volume":"64","author":"Hu","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"issue":"27","key":"2026080408084936500_cit39","doi-asserted-by":"publisher","first-page":"14847","DOI":"10.1021\/acs.analchem.5c03077","article-title":"A bienzyme-locked\nactivatable photoacoustic probe for precise in vivo imaging of drug-induced\nliver injury","volume":"97","author":"Liu","year":"2025","journal-title":"Anal. Chem."},{"issue":"2","key":"2026080408084936500_cit40","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1021\/acssensors.4c02872","article-title":"Hypochlorous\nacid-activatable\nnir fluorescence\/photoacoustic dual-modal probe with high signal-to-background\nratios for imaging of liver injury and plasma diagnosis of sepsis","volume":"10","author":"Mao","year":"2025","journal-title":"ACS Sens."},{"issue":"17","key":"2026080408084936500_cit41","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201908530","article-title":"Fluoro-photoacoustic polymeric renal\nreporter for real-time dual\nimaging of acute kidney injury","volume":"32","author":"Cheng","year":"2020","journal-title":"Adv. Mater."},{"issue":"40","key":"2026080408084936500_cit42","doi-asserted-by":"publisher","first-page":"9257","DOI":"10.1039\/C9SC02764E","article-title":"Engineering\nan NIR rhodol derivative with spirocyclic ring-opening activation\nfor high-contrast photoacoustic imaging","volume":"10","author":"Liu","year":"2019","journal-title":"Chem.\nSci."},{"issue":"20","key":"2026080408084936500_cit43","doi-asserted-by":"publisher","first-page":"14244","DOI":"10.1021\/acs.analchem.0c03506","article-title":"Mitochondria-targeted\nfluorescent and photoacoustic imaging of hydrogen peroxide in inflammation","volume":"92","author":"Chen","year":"2020","journal-title":"Anal. Chem."},{"issue":"1","key":"2026080408084936500_cit44","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27233-4","article-title":"A H2O2-activatable nanoprobe\nfor diagnosing interstitial cystitis and liver ischemia-reperfusion\ninjury via multispectral optoacoustic tomography and NIR-II fluorescent\nimaging","volume":"12","author":"Chen","year":"2021","journal-title":"Nat. Commun."},{"key":"2026080408084936500_cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2023.115399","article-title":"An activatable near-infrared\nmolecular reporter for fluoro-photoacoustic\nimaging of liver fibrosis","volume":"235","author":"Miao","year":"2023","journal-title":"Biosens. Bioelectron."},{"issue":"13","key":"2026080408084936500_cit46","doi-asserted-by":"publisher","first-page":"8085","DOI":"10.1021\/acs.analchem.9b00107","article-title":"Diagnosing drug-induced\nliver injury by multispectral optoacoustic tomography and fluorescence\nimaging using a leucine-aminopeptidase-activated probe","volume":"91","author":"Huang","year":"2019","journal-title":"Anal. Chem."},{"issue":"4","key":"2026080408084936500_cit47","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.1021\/acs.analchem.2c05476","article-title":"Liver-targeted near-infrared fluorescence\/photoacoustic\ndual-modal probe for real-time imaging of in situ hepatic inflammation","volume":"95","author":"Zhang","year":"2023","journal-title":"Anal. Chem."},{"issue":"39","key":"2026080408084936500_cit48","doi-asserted-by":"publisher","first-page":"21679","DOI":"10.1021\/acs.analchem.5c04531","article-title":"A near-infrared\nfluorescent probe for dynamic monitoring\nof superoxide anions for early diagnosis of cuproptosis-mediated acute\nkidney injury","volume":"97","author":"Su","year":"2025","journal-title":"Anal. Chem."},{"key":"2026080408084936500_cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2025.128269","article-title":"BODIPY-based small\nmolecular probes for fluorescence and photoacoustic dual-modality\nimaging of superoxide anion in vivo","volume":"294","author":"Zhou","year":"2025","journal-title":"Talanta"},{"key":"2026080408084936500_cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2024.136953","article-title":"A superoxide\nanion activatable 7-Azaindole derived photoacoustic probe for high-contrast\nimaging of drug-induced liver injury","volume":"425","author":"Liu","year":"2025","journal-title":"Sens.\nActuators, B"},{"issue":"21","key":"2026080408084936500_cit51","doi-asserted-by":"publisher","first-page":"8367","DOI":"10.1021\/acs.analchem.3c01068","article-title":"Uncovering endoplasmic reticulum superoxide regulating hepatic ischemia-reperfusion\ninjury by dynamic reversible fluorescence imaging","volume":"95","author":"Zhang","year":"2023","journal-title":"Anal. Chem."},{"issue":"36","key":"2026080408084936500_cit52","doi-asserted-by":"publisher","first-page":"19662","DOI":"10.1021\/jacs.3c04303","article-title":"Unveiling the crucial\nroles of O2\u2022\u2013 and\nATP in hepatic ischemia\u2013reperfusion injury using dual-color\/reversible\nfluorescence imaging","volume":"145","author":"Liu","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"46","key":"2026080408084936500_cit53","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202411840","article-title":"Simultaneous in vivo imaging of neutrophil\nelastase and oxidative stress in atherosclerotic plaques using a unimolecular\nphotoacoustic probe","volume":"63","author":"Ma","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"issue":"46","key":"2026080408084936500_cit54","doi-asserted-by":"publisher","first-page":"21010","DOI":"10.1021\/jacs.2c10041","article-title":"Polymethine\nmolecular platform for ratiometric fluorescent probes in the second\nnear-infrared window","volume":"144","author":"Lan","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"7","key":"2026080408084936500_cit55","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1021\/tx960052v","article-title":"Synthesis, redox properties, in vivo\nformation, and neurobehavioral effects of N-acetylcysteinyl conjugates\nof dopamine: possible metabolites of relevance to Parkinson\u2019s\ndisease","volume":"9","author":"Shen","year":"1996","journal-title":"Chem. Res. Toxicol."},{"issue":"40","key":"2026080408084936500_cit56","doi-asserted-by":"publisher","first-page":"14956","DOI":"10.1021\/ja408524j","article-title":"Dynamic and\nreversible fluorescence\nimaging of superoxide anion fluctuations in live cells and in vivo","volume":"135","author":"Zhang","year":"2013","journal-title":"J. Am. Chem. Soc."},{"issue":"49","key":"2026080408084936500_cit57","doi-asserted-by":"publisher","first-page":"20735","DOI":"10.1021\/jacs.0c09576","article-title":"Oxidative\ndamage of tryptophan hydroxylase-2\nmediated by peroxisomal superoxide anion radical in brains of mouse\nwith depression","volume":"142","author":"Ding","year":"2020","journal-title":"J. Am. Chem. Soc."},{"issue":"9","key":"2026080408084936500_cit58","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202214505","article-title":"A photoacoustic probe\nwith blood-brain barrier crossing ability for imaging oxidative stress\ndynamics in the mouse brain","volume":"62","author":"Cui","year":"2023","journal-title":"Angew. Chem., Int.\nEd."},{"issue":"39","key":"2026080408084936500_cit59","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202003628","article-title":"Near-infrared\nchemiluminescent reporters for in vivo imaging of reactive oxygen\nand nitrogen species in kidneys","volume":"30","author":"Huang","year":"2020","journal-title":"Adv. Funct.\nMater."},{"issue":"40","key":"2026080408084936500_cit60","doi-asserted-by":"publisher","first-page":"15102","DOI":"10.1021\/acs.analchem.3c03233","article-title":"New perylene-based chemiluminescent polymer nanoparticles for highly\nselective detection of the superoxide anion in vivo","volume":"95","author":"Guo","year":"2023","journal-title":"Anal. Chem."},{"issue":"2","key":"2026080408084936500_cit61","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1021\/acs.analchem.5c06051","article-title":"Near-infrared chemiluminescence probe\nfor superoxide anion imaging\nin Alzheimer\u2019s disease","volume":"98","author":"Mao","year":"2026","journal-title":"Anal. Chem."},{"issue":"2","key":"2026080408084936500_cit62","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2334-2","article-title":"Ferroptosis driven by radical oxidation\nof n-6 polyunsaturated fatty acids mediates acetaminophen-induced\nacute liver failure","volume":"11","author":"Yamada","year":"2020","journal-title":"Cell Death Dis."},{"issue":"13","key":"2026080408084936500_cit63","doi-asserted-by":"publisher","first-page":"4712","DOI":"10.1021\/jacs.8b01462","article-title":"Quantitative profiling\nof protein carbonylations in ferroptosis by an aniline-derived probe","volume":"140","author":"Chen","year":"2018","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"2026080408084936500_cit64","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.bbrc.2016.03.052","article-title":"Identification\nof baicalein as a ferroptosis inhibitor by natural product library\nscreening","volume":"473","author":"Xie","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"2026080408084936500_cit65","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis:\na regulated cell death nexus linking metabolism, redox biology, and\ndisease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.6c02848","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/30\/22418\/66035176\/acs.analchem.6c02848.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/30\/22418\/66035176\/acs.analchem.6c02848.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:26:32Z","timestamp":1785846392000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancham\/article\/98\/30\/22418\/5215836\/Photoacoustic-Probe-for-Rapidly-Recognizing"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,20]]},"references-count":65,"journal-issue":{"issue":"30","published-online":{"date-parts":[[2026,7,20]]},"published-print":{"date-parts":[[2026,8,4]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.6c02848","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,20]]}}}