{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:06:07Z","timestamp":1790690767184,"version":"4.1.0"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22174164"],"award-info":[{"award-number":["22174164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22336007"],"award-info":[{"award-number":["22336007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22576042"],"award-info":[{"award-number":["22576042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25A20591"],"award-info":[{"award-number":["U25A20591"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","award":["2024B1515020070"],"award-info":[{"award-number":["2024B1515020070"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National High-Level Talents Special Support Program?Young Talents","doi-asserted-by":"publisher","award":["2024WRQB006"],"award-info":[{"award-number":["2024WRQB006"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mucin 1 (MUC1) is an important biomarker for epithelial-derived malignancies, yet its ultratrace abundance in early tumorigenesis demands analytical methods with exceptional sensitivity. Herein, we report an ultrasensitive electrochemical aptasensing platform that integrates a biomimetic supramolecular crystal with target recycling amplification (TRA) and catalytic hairpin assembly (CHA). The supramolecular crystal (Fe-TCPP-SC) is rationally engineered by direct self-assembly of Fe(III) meso-tetra(4-carboxyphenyl)porphyrin (Fe-TCPP-(COOH)4) via hydrogen bonding, eliminating inactive metal nodes and maximizing the volumetric density of accessible peroxidase-mimicking active sites. Fe-TCPP-SC exhibits superior peroxidase-like activity and electrochemical signal amplification compared to conventional nanozymes (Fe3O4) and a representative porphyrin-based MOF (PCN-222-Fe), primarily due to its dense yet accessible iron-porphyrin motifs. By coupling Fe-TCPP-SC with TRA and CHA on a gold electrode, we developed an aptasensor translating MUC1 recognition into massively amplified electrochemical readout, with sensitivity and quantitative range outperforming most reported MUC1 assays. This aptasensor also demonstrates high specificity against common interferents (myoglobin, glucose oxidase, BSA, cholesterol, MUC2 and CA125) and excellent reproducibility (RSD = 0.89%). Furthermore, quantitative analysis of MUC1 in diluted human serum yields recoveries of 96.9-109.5%, confirming robust performance in complex biological matrices. This work establishes that hydrogen-bonded supramolecular crystals can serve as highly efficient electroactive beacons, offering a promising strategy for early cancer diagnosis.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c03353","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:02:07Z","timestamp":1789462927000},"page":"28180-28189","source":"Crossref","is-referenced-by-count":0,"title":["Integrating Peroxidase-like Supramolecular Crystal\nwith Nucleic Acid Amplification Cascades for Ultrasensitive Electrochemical\nDetection of Mucin 1"],"prefix":"10.1021","volume":"98","author":[{"given":"Wei","family":"Huang","sequence":"first","affiliation":[{"name":"Sun Yat-Sen University , , ,","place":["Zhuhai, China, 519082"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gan","family":"Luo","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , ,","place":["Zhuhai, China, 519082"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Liang","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailin","family":"Guo","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjing","family":"Tong","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningyi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Cai","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoying","family":"Guo","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0912-1082","authenticated-orcid":true,"given":"Siming","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangzhou Medical University , , ,","place":["Guangzhou, China, 511436"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6540-7675","authenticated-orcid":true,"given":"Guosheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , ,","place":["Zhuhai, China, 519082"]},{"name":"Sun Yat-Sen University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-6036","authenticated-orcid":true,"given":"Gangfeng","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , ,","place":["Zhuhai, China, 519082"]},{"name":"Sun Yat-Sen University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"2026092909094666400_cit1","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1038\/nrc2761","article-title":"Mucins\nin cancer: Function, prognosis and therapy","volume":"9","author":"Kufe","year":"2009","journal-title":"Nat. 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Chem."},{"key":"2026092909094666400_cit5","doi-asserted-by":"publisher","first-page":"3380","DOI":"10.1021\/acs.analchem.9b05444","article-title":"Matrix\ncoordination-induced electrochemiluminescence\nenhancement of tetraphenylethylene-based hafnium metal-organic framework:\nAn electrochemiluminescence chromophore for ultrasensitive electrochemiluminescence\nsensor construction","volume":"92","author":"Huang","year":"2020","journal-title":"Anal. Chem."},{"key":"2026092909094666400_cit6","doi-asserted-by":"publisher","first-page":"12767","DOI":"10.1021\/acs.analchem.4c01954","article-title":"Target-triggered\naggregation of modified E. coli for\ndiagnosis of ovarian cancer","volume":"96","author":"Mu","year":"2024","journal-title":"Anal. 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Bioelectron."},{"key":"2026092909094666400_cit40","doi-asserted-by":"publisher","first-page":"13734","DOI":"10.1021\/acs.analchem.1c03545","article-title":"Multicolor covalent organic framework-DNA\nnanoprobe\nfor fluorescence imaging of biomarkers with different locations in\nliving cells","volume":"93","author":"Gao","year":"2021","journal-title":"Anal. Chem."},{"key":"2026092909094666400_cit41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39364-x","article-title":"Green synthesis\nof stable hybrid biocatalyst using a hydrogen-bonded, \u03c0-\u03c0-stacking\nsupramolecular assembly for electrochemical immunosensor","volume":"14","author":"Huang","year":"2023","journal-title":"Nat. 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