{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:42:08Z","timestamp":1792784528916,"version":"4.5.0"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"37","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"National Natural Science Foundation of China (NSFC)","award":["NSFC 22575115"],"award-info":[{"award-number":["NSFC 22575115"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["NSFC U25A20585"],"award-info":[{"award-number":["NSFC U25A20585"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mapping catalytic activity at the single-nanoparticle level is critical for the rational design of high-performance materials. However, current optical techniques are fundamentally limited by molecular diffusion blur. This physical decoupling of the luminescent signal from the catalytic site creates a \u201cspatial information gap\u201d that post-processing alone cannot reconcile. Here, we report a super-resolved imaging platform that overcomes this limitation by utilizing the nanoconfinement effect within a Vertically Oriented Silica Mesoporous Film (VSMF). By confining light-emitting species within vertical nanochannels, we effectively suppress lateral diffusion and regulate mass transport. While bare Pt sites suffer over 70% signal collapse within 20 seconds due to rapid reactant depletion, the VSMF-encapsulated sites maintain a quasi-steady-state flux with only \u223c20% decay. When integrated with Super-Resolution Radial Fluctuation (SRRF) algorithms, this platform achieves a spatial resolution significantly below the diffraction limit. This approach revealed that the ECL reaction flux redistributes from the core to the boundary of Pt aggregates as the system transitions from a kinetically controlled to a diffusion-controlled regime. Our work provides a powerful strategy for real-time, super-resolution characterization of nanocatalytic dynamics with extraordinary spatiotemporal accuracy.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c03393","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:01:19Z","timestamp":1789030879000},"page":"27423-27430","source":"Crossref","is-referenced-by-count":0,"title":["Vertical Nanoconfinement\nSuppresses Lateral Diffusion\nfor Super-Resolved Spatiotemporal Mapping of Nanocatalytic Dynamics"],"prefix":"10.1021","volume":"98","author":[{"given":"Ying","family":"Wei","sequence":"first","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Likang","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Jin","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Sun","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1743-5919","authenticated-orcid":true,"given":"Weihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9616-8814","authenticated-orcid":true,"given":"Zhenda","family":"Lu","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"issue":"32","key":"2026092208063904800_cit1","doi-asserted-by":"publisher","first-page":"12787","DOI":"10.1021\/ja204557m","article-title":"Structure\nSensitivity of Alkynol Hydrogenation on Shape- and Size-Controlled\nPalladium Nanocrystals: Which Sites Are Most Active and Selective?","volume":"133","author":"Crespo-Quesada","year":"2011","journal-title":"J. Am. Chem. Soc"},{"issue":"1","key":"2026092208063904800_cit2","doi-asserted-by":"publisher","first-page":"7583","DOI":"10.1038\/ncomms8583","article-title":"Complex structural\ndynamics of nanocatalysts revealed\nin Operando conditions by correlated imaging and spectroscopy probes","volume":"6","author":"Li","year":"2015","journal-title":"Nat. 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Electroanal. Chem"},{"issue":"31","key":"2026092208063904800_cit27","doi-asserted-by":"publisher","first-page":"13305","DOI":"10.1021\/jacs.0c05905","article-title":"Single Molecule Investigation of\nNanoconfinement Hydrophobicity in Heterogeneous Catalysis","volume":"142","author":"Dong","year":"2020","journal-title":"J. Am. Chem. Soc"},{"issue":"1","key":"2026092208063904800_cit28","doi-asserted-by":"publisher","first-page":"4815","DOI":"10.1038\/s41467-019-12799-x","article-title":"Deciphering nanoconfinement\neffects on molecular orientation and\nreaction intermediate by single molecule imaging","volume":"10","author":"Dong","year":"2019","journal-title":"Nat. Commun"},{"issue":"2","key":"2026092208063904800_cit29","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/s41929-017-0021-1","article-title":"In situ quantitative\nsingle-molecule study of dynamic catalytic processes in nanoconfinement","volume":"1","author":"Dong","year":"2018","journal-title":"Nat. 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