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A flowing fluid interface across a viscosity gradient (viscous-stratification region) drives complex hydrodynamic events\u2500vortices, mixing in an otherwise laminar interface, with implications for active colloids, interfacial bioprocesses, tissue engineering, microfluidic diagnosis, etc. To date, the formation of liquid\u2013liquid phase separation (LLPS)-driven membraneless biocondensates in the viscous-stratification zone has received little attention. We demonstrate LLPS-mediated DNA\u2013spermine condensate formation within the hydrodynamically unstable region inside a microfluidic device under continuous flow, with varying solution viscosity (\u03b7). The viscosity (\u03b7) was varied by altering the amount and size of the crowding agent, polyethylene glycol. The width of the DNA\u2013spermine condensate clustering zone increases (\u223c2.3-fold higher than in the aqueous buffered system alone) with increasing interfacial \u0394\u03b7. Coarsening and the skewness of the condensate size distribution undergo a distinct change at the interface with contrasting viscosities. Finally, we extended this approach to a noncontinuous fluidic system to demonstrate its potential as a microliter-scale viscometric technique (with millimeter-scale spatial sensitivity) using blood serum samples, relevant for pathological gamma-globulin analysis.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c03591","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:21:19Z","timestamp":1785849679000},"page":"23325-23334","source":"Crossref","is-referenced-by-count":1,"title":["Spatially Extended\nDNA Phase Separation in Viscosity-Stratified\nMiscible Interfaces: Application in Microliter Viscometry"],"prefix":"10.1021","volume":"98","author":[{"given":"Sakshi","family":"Juneja","sequence":"first","affiliation":[{"name":"Indian Institute of Science Education and Research (IISER) Mohali , , Knowledge City , ,","place":["Manauli, India, 140306"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2554-0762","authenticated-orcid":true,"given":"Subhabrata","family":"Maiti","sequence":"additional","affiliation":[{"name":"Indian Institute of Science Education and Research (IISER) Mohali , , Knowledge City , ,","place":["Manauli, India, 140306"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"issue":"1","key":"2026081109092549700_cit1","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1146\/annurev-fluid-010313-141351","article-title":"Instabilities in Viscosity-Stratified Flow","volume":"46","author":"Govindarajan","year":"2014","journal-title":"Annu. 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