{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:44:18Z","timestamp":1792784658051,"version":"4.5.0"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2026-MS-117"],"award-info":[{"award-number":["2026-MS-117"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["32102086"],"award-info":[{"award-number":["32102086"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Discriminating structurally similar antibiotics requires analytical strategies that simultaneously achieve cross-class differentiation and intra-class fine identification\u2500a persistent challenge in chemical sensing. Herein, we report a hierarchical molecular recognition platform based on a single mixed-ligand Eu\/Cd heterometallic metal\u2013organic framework (MOF) featuring atomically homogeneous emissive centers. Precise Eu3+ substitution at Cd2+ nodes yields two spectrally distinct emission channels at 450 nm (ligand-centered) and 612 nm (Eu3+-centered), which generate characteristic fluorescence fingerprints through analyte-specific differential modulation. Configured as a dual-channel sensor array, this single-MOF platform achieves 100% accurate classification of four antibiotic classes (fluoroquinolones, tetracyclines, sulfonamides, and aminoglycosides) and precisely resolves structurally analogous fluoroquinolones (ciprofloxacin, enrofloxacin, norfloxacin) differing by &amp;lt;10% in molecular weight. Machine learning integration further enables concentration-independent discrimination of three fluoroquinolones, effectively mitigating concentration-induced signal variations and enabling robust identification of blind samples. When integrated with electrospun fibrous membranes and smartphone-based RGB imaging, the portable device enables sensitive detection of FQs in complex food matrices, including egg, milk, and honey, with recoveries of 95.73\u201399.64%. This work establishes heterometallic node engineering as a generalizable strategy for single-material multichannel sensing, effectively resolving the longstanding trade-off between analytical dimensionality and system simplicity in molecular recognition.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c03993","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:01:38Z","timestamp":1789426898000},"page":"28381-28394","source":"Crossref","is-referenced-by-count":0,"title":["Heterometallic Eu\/Cd-MOF Dual-Channel Fluorescent\nSensor Array for Hierarchical Antibiotic Discrimination: From Cross-Class\nto Intra-Class Resolution"],"prefix":"10.1021","volume":"98","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Liaoning University , , ,","place":["Shenyang, China, 110036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Liaoning University , , ,","place":["Shenyang, China, 110036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4382-227X","authenticated-orcid":true,"given":"Xu","family":"Xu","sequence":"additional","affiliation":[{"name":"Liaoning University , , ,","place":["Shenyang, China, 110036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7584-0184","authenticated-orcid":true,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Liaoning University , , ,","place":["Shenyang, China, 110036"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"2026092909102153200_cit1","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.cels.2023.10.009","article-title":"Advances in ligand-specific biosensing\nfor structurally similar molecules","volume":"14","author":"Xi","year":"2023","journal-title":"Cell Syst."},{"key":"2026092909102153200_cit2","doi-asserted-by":"publisher","first-page":"12112","DOI":"10.1039\/D3DT01830J","article-title":"Single-phase white\nlight material and antibiotic detection of lanthanide metal-organic\nframeworks","volume":"52","author":"Ding","year":"2023","journal-title":"Dalton Trans."},{"key":"2026092909102153200_cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2025.146136","article-title":"A facile and stable single-system\nfluorescent sensor\narray for the quantification and discrimination of nitrofuran antibiotics","volume":"494","author":"Xia","year":"2025","journal-title":"Food Chem."},{"key":"2026092909102153200_cit4","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s41664-025-00412-8","article-title":"Advances in\nConstructing Robust Bimetallic\nMetal-Organic Frameworks for Antibiotic Analysis","volume":"9","author":"Yang","year":"2025","journal-title":"J. Anal. 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Mater."},{"key":"2026092909102153200_cit18","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1021\/acssensors.3c02069","article-title":"Eu3+-Doped\nAnionic Zinc-Based Organic Framework Ratio Fluorescence\nSensing Platform: Supersensitive Visual Identification of Prescription\nDrugs","volume":"9","author":"Liu","year":"2024","journal-title":"ACS Sens."},{"key":"2026092909102153200_cit19","doi-asserted-by":"publisher","first-page":"6228","DOI":"10.1021\/acs.analchem.3c05282","article-title":"Multiple-Emitting\nLuminescent Metal-Organic Framework as an Array-on-a-MOF for Rapid\nScreening and Discrimination of Nitroaromatics","volume":"96","author":"Chen","year":"2024","journal-title":"Anal. 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Soc."},{"key":"2026092909102153200_cit30","doi-asserted-by":"publisher","first-page":"6874","DOI":"10.1021\/es500563q","article-title":"Americium(III) Capture\nUsing Phosphonic Acid-Functionalized Silicas with Different Mesoporous\nMorphologies: Adsorption Behavior Study and Mechanism Investigation\nby EXAFS\/XPS","volume":"48","author":"Zhang","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"2026092909102153200_cit31","doi-asserted-by":"publisher","first-page":"15088","DOI":"10.1021\/acs.inorgchem.0c02044","article-title":"Cd-Based Metal-Organic\nFramework Containing Uncoordinated Carbonyl\nGroups as Lanthanide Postsynthetic Modification Sites and Chemical\nSensing of Diphenyl Phosphate as a Flame-Retardant Biomarker","volume":"59","author":"Qu","year":"2020","journal-title":"Inorg. Chem."},{"key":"2026092909102153200_cit32","doi-asserted-by":"publisher","first-page":"15806","DOI":"10.1021\/acs.inorgchem.2c01988","article-title":"Dual Emission\nin the Near-Infrared and Visible Regions from a Mixed Cyanido-Bridged\nEuIII\/NdIII(4-OHpy)-CoIII Layered Material","volume":"61","author":"Karachousos-Spiliotakopoulos","year":"2022","journal-title":"Inorg. Chem."},{"key":"2026092909102153200_cit33","doi-asserted-by":"publisher","first-page":"15166","DOI":"10.1021\/jacs.9b06755","article-title":"Rotation Restricted Emission and\nAntenna Effect in Single Metal-Organic Frameworks","volume":"141","author":"Yin","year":"2019","journal-title":"J. Am. Chem. 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B"},{"key":"2026092909102153200_cit42","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1021\/acs.chemrev.4c00615","article-title":"Luminescent\nLanthanides in Biorelated Applications: From Molecules to Nanoparticles\nand Diagnostic Probes to Therapeutics","volume":"125","author":"Alexander","year":"2025","journal-title":"Chem.\nRev."},{"key":"2026092909102153200_cit43","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1021\/cr010452+","article-title":"Being Excited by Lanthanide Coordination Complexes:\nAqua Species, Chirality, Excited-State Chemistry, and Exchange Dynamics","volume":"102","author":"Parker","year":"2002","journal-title":"Chem. Rev."},{"key":"2026092909102153200_cit44","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1021\/cbmi.3c00091","article-title":"Chemical Regulation of Fluorescence Lifetime","volume":"1","author":"Dai","year":"2023","journal-title":"Chem. Biomed. 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Commun."},{"key":"2026092909102153200_cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.135853","article-title":"Highly sensitive fluorescent\nquantification\nof carbendazim by two-dimensional Tb-MOF nanosheets for food safety","volume":"416","author":"Wang","year":"2023","journal-title":"Food Chem."},{"key":"2026092909102153200_cit49","doi-asserted-by":"publisher","first-page":"44626","DOI":"10.1038\/s41598-025-31426-y","article-title":"Dual mode fluorescence\nand spectrophotometric cefixime\nsensing using onion juice nitrogen doped carbon dots with smartphone\nand paper strip readouts","volume":"15","author":"Asadi","year":"2025","journal-title":"Sci. Rep."}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.6c03993","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/38\/28381\/68506046\/acs.analchem.6c03993.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/38\/28381\/68506046\/acs.analchem.6c03993.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:43:47Z","timestamp":1790689427000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancham\/article\/98\/38\/28381\/5429686\/Heterometallic-Eu-Cd-MOF-Dual-Channel-Fluorescent"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":49,"journal-issue":{"issue":"38","published-online":{"date-parts":[[2026,9,14]]},"published-print":{"date-parts":[[2026,9,29]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.6c03993","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]}}}