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Whereas, the inferior reliability and high cost\/complexity induced by the limited-modal outputs and commonly used multicomponent nanozymes in existing works are still drawbacks that cannot be ignored. Herein, taking galactose (Gal)\/xanthine oxidase (XOD) as typical metabolic biomarkers and the facilely obtained ZnTcPP(Fe) MOF as a representative single-component nanozyme, we constructed a universal fluorescent-colorimetric-photothermal trimodal platform that seamlessly integrates high sensitivity, visual readouts, and POCT capability through the rational fusion of target-responsive enzyme\/nanozyme tandem catalysis and efficient catalytic oxidation of optical substrates. Collaborative results of spectroscopic experiments, EPR, and DFT calculations manifested the strong electron-transfer ability of Fe-sites within the single-component nanozyme, wherein \u2022OH and O2\u2022\u2013 that generated via H2O2 dissociation worked as the pivotal ROS. Noteworthy, the trimodal outputs could achieve multitrack cooperative sensing via their complementary advantages, which evidently improved cost-effectiveness, reliability, and compatibility. The LODs for Gal and XOD were satisfactory in all three modes, which could compete with many previous works. Moreover, this platform demonstrated acceptable adaptability in human serum samples. This work not only provides a canonical paradigm for the accurate analysis of metabolic markers and diagnostics of related diseases but also paves unique pathways for the exploration of economical and robust nanozyme-based multimodal sensors.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c04034","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:02:16Z","timestamp":1786982536000},"page":"25320-25331","source":"Crossref","is-referenced-by-count":0,"title":["Enzyme\/Nanozyme\nCascade Catalysis-Driven Trimodal\nPlatform Using a Readily Prepared Single-Component Nanozyme for Highly\nEfficient Metabolic Biomarker Assays"],"prefix":"10.1021","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1871-0653","authenticated-orcid":true,"given":"Juan","family":"Wang","sequence":"first","affiliation":[{"name":"Ocean University of China , , , ,","place":["Qingdao, Shandong, China, 266003"]},{"name":"Qingdao Marine Science and Technology Center , , , ,","place":["Qingdao, Shandong, China, 266237"]},{"name":"Chinese Academy of Sciences , , ,","place":["Changchun, China, 130022"]},{"name":"Qingdao University , , ,","place":["Qingdao, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengqian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ocean University of China , , , ,","place":["Qingdao, Shandong, China, 266003"]},{"name":"Qingdao Marine Science and Technology Center , , , ,","place":["Qingdao, Shandong, China, 266237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilin","family":"Hao","sequence":"additional","affiliation":[{"name":"Ocean University of China , , , ,","place":["Qingdao, Shandong, China, 266003"]},{"name":"Qingdao Marine Science and Technology Center , , , ,","place":["Qingdao, Shandong, China, 266237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Hou","sequence":"additional","affiliation":[{"name":"Ocean University of China , , , ,","place":["Qingdao, Shandong, China, 266003"]},{"name":"Qingdao Marine Science and Technology Center , , , ,","place":["Qingdao, Shandong, China, 266237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Guo","sequence":"additional","affiliation":[{"name":"Ocean University of China , , , ,","place":["Qingdao, Shandong, China, 266003"]},{"name":"Qingdao Marine Science and Technology Center , , , ,","place":["Qingdao, Shandong, China, 266237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0263-6577","authenticated-orcid":true,"given":"Shaojun","family":"Dong","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Changchun, China, 130022"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3755-3691","authenticated-orcid":true,"given":"Daoqing","family":"Fan","sequence":"additional","affiliation":[{"name":"Ocean University of China , , , ,","place":["Qingdao, Shandong, China, 266003"]},{"name":"Qingdao Marine Science and Technology Center , , , ,","place":["Qingdao, Shandong, China, 266237"]},{"name":"Chinese Academy of Sciences , , ,","place":["Changchun, China, 130022"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"issue":"1","key":"2026090306470291500_cit1","doi-asserted-by":"publisher","first-page":"5171","DOI":"10.1038\/s41467-024-49619-w","article-title":"Environmental and genetic regulation of Streptococcus\npneumoniae galactose catabolic pathways","volume":"15","author":"Kareem","year":"2024","journal-title":"Nat.\nCommun."},{"key":"2026090306470291500_cit2","doi-asserted-by":"publisher","first-page":"112560","DOI":"10.1016\/j.jphotochem.2020.112560","article-title":"A photoelectrochemical\nbiosensor based on the direct electron transfer\nto galactose oxidase","volume":"397","author":"Yin","year":"2020","journal-title":"J. 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Bioelectron."},{"issue":"3","key":"2026090306470291500_cit24","doi-asserted-by":"publisher","first-page":"20240275","DOI":"10.1002\/EXP.20240275","article-title":"Spatial Isolation of Single Copper(I) Sites for Cascade Enzyme-Like\nCatalysis and Simultaneous Ferroptosis\/Cuproptosis Boosted Immunotherapy","volume":"5","author":"Zhang","year":"2025","journal-title":"Exploration"},{"issue":"3","key":"2026090306470291500_cit25","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1007\/s41664-024-00298-y","article-title":"Integrating Bimetallic Nanoparticles\nwith Covalent Organic Frameworks as Multifunctional Nanozyme for Colorimetric\nDetection of Hydrogen Peroxide and Glutathione","volume":"8","author":"Yuan","year":"2024","journal-title":"J. Anal. Test."},{"issue":"49","key":"2026090306470291500_cit26","doi-asserted-by":"publisher","first-page":"55324","DOI":"10.1021\/acsami.0c12988","article-title":"Enzyme-Free Tandem Reaction Strategy for Surface-Enhanced\nRaman Scattering Detection of Glucose by Using the Composite of Au\nNanoparticles and Porphyrin-Based Metal\u2013Organic Framework","volume":"12","author":"Hu","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"28","key":"2026090306470291500_cit27","doi-asserted-by":"publisher","first-page":"10785","DOI":"10.1021\/acs.analchem.3c01905","article-title":"MOF-On-MOF Dual Enzyme-Mimic Nanozyme\nwith Enhanced Cascade Catalysis for Colorimetric\/Chemiluminescent\nDual-Mode Aptasensing","volume":"95","author":"Chai","year":"2023","journal-title":"Anal. 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