{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:12:11Z","timestamp":1790082731847,"version":"4.0.1"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"37","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFA151110"],"award-info":[{"award-number":["2025YFA151110"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22271305"],"award-info":[{"award-number":["22271305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22574168"],"award-info":[{"award-number":["22574168"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Separation-free determination of enantiomeric composition is valuable for the rapid evaluation of chiral nitrogen-containing compounds, but chromatographic analysis is often substrate-specific and may require tailored conditions. Here, we report probe 4, a cyclorhodium(III) complex bearing a CF3 reporter designed to convert analyte coordination into well-resolved 19F NMR readouts. The design integrates a rigid Rh(III)-centered cyclometalated scaffold, a compact trifluoromethyl reporter, and an accessible coordination site for nitrogen donors. Direct mixing with amino alcohols, primary amines, or nitriles gives new 19F resonances under slow exchange on the NMR time scale. The probe resolves a broad amine panel with Rs values of up to 92.4 and extends to weakly coordinating nitriles bearing ester, amide, acid, cyclic, and quaternary stereocenter motifs. Five-component amine and six-component nitrile mixtures were resolved in a single NMR tube. Direct crude-product analysis of copper-catalyzed asymmetric decarboxylative cyanation gives ee values consistent with those of chiral HPLC. This Rh(III)-centered 19F NMR platform combines broad nitrogen donor compatibility, spectral simplicity, multiplex readout, and quantitative ee analysis.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c04189","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:01:59Z","timestamp":1788940919000},"page":"27558-27566","source":"Crossref","is-referenced-by-count":0,"title":["A Fluorinated\nCyclorhodium Probe Enables Separation-Free 19F NMR Enantiodifferentiation\nof Chiral Amines and Nitriles"],"prefix":"10.1021","volume":"98","author":[{"given":"Guangxing","family":"Gu","sequence":"first","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Shanghai, China, 200032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianci","family":"Peng","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Shanghai, China, 200032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2903-4218","authenticated-orcid":true,"given":"Yanchuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Shanghai, China, 200032"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"2026092208062423600_cit1","doi-asserted-by":"publisher","first-page":"4466","DOI":"10.1039\/c000408c","article-title":"Pharmacologically\nactive compounds in the environment and their chirality","volume":"39","author":"Kasprzyk-Hordern","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"2026092208062423600_cit2","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/9780470771709.ch9","article-title":"Preparation\nand synthetic applications of cyano compounds","volume-title":"Triple-Bonded Functional Groups","author":"Fatiadi","year":"1983"},{"key":"2026092208062423600_cit3","doi-asserted-by":"publisher","first-page":"15115","DOI":"10.1021\/acs.jafc.0c04106","article-title":"Enantiomeric\ndibenzo-\u03b1-pyrone\nderivatives from Alternaria alternata ZHJG5 and their potential as\nagrochemicals","volume":"68","author":"Zhao","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"2026092208062423600_cit4","doi-asserted-by":"publisher","first-page":"16410","DOI":"10.1021\/acs.jmedchem.3c01866","article-title":"Discovery\nof Amino Alcohols as Highly Potent, Selective and Orally Efficacious\nInhibitors of Leukotriene A4 Hydrolase","volume":"66","author":"Thoma","year":"2023","journal-title":"J. Med.\nChem."},{"key":"2026092208062423600_cit5","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1021\/jm9506175","article-title":"Investigation of\n(oxodioxolenyl) methyl carbamates as nonchiral bioreversible prodrug\nmoieties for chiral amines","volume":"39","author":"Alexander","year":"1996","journal-title":"J. Med. Chem."},{"key":"2026092208062423600_cit6","doi-asserted-by":"publisher","first-page":"10257","DOI":"10.1021\/jm501100b","article-title":"Analysis of the Structural Diversity,\nSubstitution Patterns, and Frequency of Nitrogen Heterocycles among\nU.S. FDA Approved Pharmaceuticals","volume":"57","author":"Vitaku","year":"2014","journal-title":"J. Med. Chem."},{"key":"2026092208062423600_cit7","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1021\/acs.chemrev.5b00317","article-title":"Efficient Separation of Enantiomers Using Stereoregular\nChiral Polymers","volume":"116","author":"Shen","year":"2016","journal-title":"Chem. Rev."},{"key":"2026092208062423600_cit8","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1021\/acscentsci.7b00250","article-title":"Are We\nApproaching a Speed Limit for the Chromatographic Separation of Enantiomers?","volume":"3","author":"Welch","year":"2017","journal-title":"ACS Cent. Sci."},{"key":"2026092208062423600_cit9","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1021\/ja00783a034","article-title":"Nuclear magnetic\nresonance enantiomer reagents. Configurational\ncorrelations via nuclear magnetic resonance chemical shifts of diastereomeric\nmandelate, O-methylmandelate, and \u03b1-methoxy-\u03b1-trifluoromethylphenylacetate\n(MTPA) esters","volume":"95","author":"Dale","year":"1973","journal-title":"J. Am. Chem. Soc."},{"key":"2026092208062423600_cit10","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1021\/acs.analchem.1c04823","article-title":"trans-4-Fluoro-L-Proline: A Sensitive 19F\nNMR Probe for the Rapid Simultaneous Enantiomeric Analysis of Multicomponent\nAmines","volume":"94","author":"Huang","year":"2022","journal-title":"Anal. Chem."},{"key":"2026092208062423600_cit11","doi-asserted-by":"publisher","first-page":"4548","DOI":"10.1039\/D3AN00761H","article-title":"19F NMR enantiodiscrimination\nand diastereomeric purity determination of amino acids, dipeptides,\nand amines","volume":"148","author":"Xu","year":"2023","journal-title":"Analyst"},{"key":"2026092208062423600_cit12","doi-asserted-by":"publisher","first-page":"22768","DOI":"10.1021\/acs.analchem.5c04345","article-title":"A 19F-labeled\nIsothiocyanate Derivatizing Agent for the Chiral Discrimination of\nCyclic Secondary Amines","volume":"97","author":"Wang","year":"2025","journal-title":"Anal. Chem."},{"key":"2026092208062423600_cit13","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.1038\/nprot.2007.354","article-title":"Mosher ester\nanalysis for the determination\nof absolute configuration of stereogenic (chiral) carbinol carbons","volume":"2","author":"Hoye","year":"2007","journal-title":"Nat. Protoc."},{"key":"2026092208062423600_cit14","doi-asserted-by":"publisher","first-page":"4692","DOI":"10.1039\/D2RA00428C","article-title":"NMR analysis of the\nenantiomeric purity of chiral diols by a new chiral boron agent","volume":"12","author":"Zhang","year":"2022","journal-title":"RSC Adv."},{"key":"2026092208062423600_cit15","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1021\/ol0602351","article-title":"Simple\nProtocol for NMR Analysis of the Enantiomeric Purity of Diols","volume":"8","author":"Kelly","year":"2006","journal-title":"Org. Lett."},{"key":"2026092208062423600_cit16","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1021\/jo8019187","article-title":"Simple Chiral Derivatization\nProtocols for 1H NMR and 19F NMR Spectroscopic\nAnalysis of the Enantiopurity of Chiral Diols","volume":"74","author":"Yeste","year":"2009","journal-title":"J. Org. Chem."},{"key":"2026092208062423600_cit17","doi-asserted-by":"publisher","first-page":"17398","DOI":"10.1021\/acs.analchem.5c01628","article-title":"Chiral Discrimination of Organothiols\nvia 19F NMR and\na Multicomponent Reaction","volume":"97","author":"Zeng","year":"2025","journal-title":"Anal. Chem."},{"key":"2026092208062423600_cit18","doi-asserted-by":"publisher","first-page":"129057","DOI":"10.1016\/j.talanta.2025.129057","article-title":"Enantiomeric\ndifferentiation of chiral diols via 19F NMR using a multicomponent\napproach: Observing the isotopic influence of boron","volume":"298","author":"Ma","year":"2026","journal-title":"Talanta"},{"key":"2026092208062423600_cit19","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1021\/jo2016554","article-title":"Diastereoselective Preparation of\n(R)- and (S)-2-Methoxy-2-phenylpent-3-ynoic\nAcids\nand Their Use as Reliable Chiral Derivatizing Agents","volume":"77","author":"Pe\u0301rez-Estrada","year":"2012","journal-title":"J. Org. Chem."},{"key":"2026092208062423600_cit20","doi-asserted-by":"publisher","first-page":"200112","DOI":"10.1016\/j.mrl.2024.200112","article-title":"Enantiodifferentiation of Chiral\nDiols and Diphenols via Recognition-Enabled Chromatographic 19F NMR","volume":"4","author":"Zeng","year":"2024","journal-title":"Magn. Reson. Lett."},{"key":"2026092208062423600_cit21","doi-asserted-by":"publisher","first-page":"12912","DOI":"10.1021\/acs.joc.0c01510","article-title":"The Assignment\nof the Absolute Configuration of \u03b2-Chiral Primary Alcohols with\nAxially Chiral Trifluoromethylbenzimidazolylbenzoic Acid","volume":"85","author":"Kriegelstein","year":"2020","journal-title":"J. Org. Chem."},{"key":"2026092208062423600_cit22","doi-asserted-by":"publisher","first-page":"7487","DOI":"10.1021\/acs.analchem.4c00053","article-title":"Enantiospecific analysis of carboxylic\nacids using cinchona alkaloid dimers as chiral solvating agents","volume":"96","author":"Mo","year":"2024","journal-title":"Anal. Chem."},{"key":"2026092208062423600_cit23","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1021\/acs.analchem.4c06024","article-title":"DACH-Based\nChiral Sensing Platforms as Tunable Benzamide-Chiral Solvating Agents\nfor NMR Enantioselective Discrimination","volume":"97","author":"Shi","year":"2025","journal-title":"Anal.\nChem."},{"key":"2026092208062423600_cit24","doi-asserted-by":"publisher","first-page":"5188","DOI":"10.1021\/acs.analchem.3c05395","article-title":"Chiral recognition\nof chiral (hetero)cyclic derivatives probed by tetraaza macrocyclic\nchiral solvating agents via 1H NMR spectroscopy","volume":"96","author":"Wang","year":"2024","journal-title":"Anal. Chem."},{"key":"2026092208062423600_cit25","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1021\/acs.analchem.1c04834","article-title":"Determining\nthe Enantiomeric Excess and Absolute Configuration of In Situ Fluorine-Labeled\nAmines and Alcohols by 19F NMR Spectroscopy","volume":"94","author":"Jang","year":"2022","journal-title":"Anal. Chem."},{"key":"2026092208062423600_cit26","doi-asserted-by":"publisher","first-page":"17726","DOI":"10.1021\/acs.analchem.3c03586","article-title":"Chiral Discrimination\nof Monosaccharides Derivatized with 2-Fluorophenyl\nHydrazine Using 19F NMR Spectroscopy","volume":"95","author":"Kim","year":"2023","journal-title":"Anal. Chem."},{"key":"2026092208062423600_cit27","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1021\/acs.orglett.3c00384","article-title":"Chiral Recognition\nand Resolution of Phosphoric Acids Using Octahedral Cobalt Complexes","volume":"25","author":"Kwahk","year":"2023","journal-title":"Org. Lett."},{"key":"2026092208062423600_cit28","doi-asserted-by":"publisher","first-page":"7829","DOI":"10.1021\/acs.orglett.1c02847","article-title":"Chiral Recognition\nof In Situ-Oxidized\nPhosphine Oxides with Octahedral Indium Complexes by 31P NMR Spectroscopy","volume":"23","author":"Kwahk","year":"2021","journal-title":"Org. Lett."},{"key":"2026092208062423600_cit29","doi-asserted-by":"publisher","first-page":"7804","DOI":"10.1021\/acs.orglett.0c02620","article-title":"Direct Chiral 19F NMR Analysis of Fluorine-Containing\nAnalytes and Its Application to Simultaneous Chiral Analysis","volume":"22","author":"Jang","year":"2020","journal-title":"Org. Lett."},{"key":"2026092208062423600_cit30","doi-asserted-by":"publisher","first-page":"4185","DOI":"10.1021\/acs.orglett.0c01256","article-title":"Chiral 1H NMR Analysis of Carbonyl Compounds Enabled by\nCationic Cobalt Complex","volume":"22","author":"Jang","year":"2020","journal-title":"Org. Lett."},{"key":"2026092208062423600_cit31","doi-asserted-by":"publisher","first-page":"6804","DOI":"10.1039\/C8CC00574E","article-title":"A Chiral Aluminum\nSolvating Agent\n(CASA) for 1H NMR Chiral Analysis of Alcohols at Low Temperature","volume":"54","author":"Seo","year":"2018","journal-title":"Chem. Commun."},{"key":"2026092208062423600_cit32","doi-asserted-by":"publisher","first-page":"14190","DOI":"10.1021\/jacs.5b09555","article-title":"1H NMR Chiral\nAnalysis of Charged Molecules via Ion Pairing\nwith Aluminum Complexes","volume":"137","author":"Seo","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"2026092208062423600_cit33","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1039\/C6QO00521G","article-title":"Discrimination\nof Enantiomers of\nDipeptide Derivatives with Two Chiral Centers by Tetraaza Macrocyclic\nChiral Solvating Agents Using 1H NMR Spectroscopy","volume":"3","author":"Fang","year":"2016","journal-title":"Org. Chem. Front."},{"key":"2026092208062423600_cit34","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1039\/C6OB02578A","article-title":"Chiral discrimination\nof \u03b1-hydroxy acids and N-Ts-\u03b1-amino\nacids induced by tetraaza macrocyclic chiral solvating agents by using 1H NMR spectroscopy","volume":"15","author":"Lv","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"2026092208062423600_cit35","doi-asserted-by":"publisher","first-page":"7381","DOI":"10.1021\/acs.joc.1c00340","article-title":"A dimeric thiourea\nCSA for the enantiodiscrimination of amino acid derivatives by NMR\nspectroscopy","volume":"86","author":"Recchimurzo","year":"2021","journal-title":"J. Org. Chem."},{"key":"2026092208062423600_cit36","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1021\/jo961562x","article-title":"A New Stereochemical Model from NMR\nfor Benzoylated Cyclodextrins, Promising New Chiral Solvating Agents\nfor the Chiral Analysis of 3,5-Dinitrophenyl Derivatives","volume":"62","author":"Uccello-Barretta","year":"1997","journal-title":"J. Org. Chem."},{"key":"2026092208062423600_cit37","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3762\/bjoc.13.6","article-title":"Phosphated cyclodextrins\nas water-soluble chiral NMR\nsolvating agents for cationic compounds","volume":"13","author":"Puentes","year":"2017","journal-title":"Beilstein\nJ. Org. Chem."},{"key":"2026092208062423600_cit38","doi-asserted-by":"publisher","first-page":"16801","DOI":"10.1021\/acs.analchem.3c01613","article-title":"BINOL as\na Chiral Solvating Agent\nfor Sulfiniminoboronic Acids","volume":"95","author":"Groleau","year":"2023","journal-title":"Anal. Chem."},{"key":"2026092208062423600_cit39","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1021\/jo00422a061","article-title":"Chiral\nRecognition Studies of \u03b1-(Nonafluoro-tert-butoxy)carboxylic\nAcids by NMR Spectroscopy","volume":"42","author":"Pirkle","year":"1977","journal-title":"J. Org. Chem."},{"key":"2026092208062423600_cit40","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1021\/jacs.5b00556","article-title":"Simultaneous Chirality Sensing of\nMultiple Amines by 19F NMR","volume":"137","author":"Zhao","year":"2015","journal-title":"J. Am.\nChem. Soc."},{"key":"2026092208062423600_cit41","doi-asserted-by":"publisher","first-page":"10717","DOI":"10.1021\/acs.inorgchem.7b01681","article-title":"Discrimination and\nEnantiomeric Excess Determination of Chiral Primary\nAmines Based on a Chiral-at-Metal Ir(III) Complex Using NMR Spectroscopy","volume":"56","author":"Li","year":"2017","journal-title":"Inorg. Chem."},{"key":"2026092208062423600_cit42","doi-asserted-by":"publisher","first-page":"6098","DOI":"10.1039\/C9CC01942A","article-title":"A Chiral Sensor for Recognition of\nVaried Amines Based on 19F NMR Signals of Newly Designed\nRhodium Complexes","volume":"55","author":"Wang","year":"2019","journal-title":"Chem. Commun."},{"key":"2026092208062423600_cit43","doi-asserted-by":"publisher","first-page":"14591","DOI":"10.1021\/acs.analchem.9b03661","article-title":"Chiral discrimination by a binuclear\nPd complex sensor using 31P{1H} NMR","volume":"91","author":"Chen","year":"2019","journal-title":"Anal. Chem."},{"key":"2026092208062423600_cit44","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202505700","article-title":"A 19F-Labeled\nProbe for the Chiral Discrimination\nof Thiols and Thioethers","volume":"64","author":"Weng","year":"2025","journal-title":"Angew. Chem., Int.\nEd."},{"key":"2026092208062423600_cit45","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1021\/acsmeasuresciau.5c00104","article-title":"A Universal 19F NMR Probe\nfor Enantiomeric Discrimination of Primary, Secondary, and Tertiary\nAmines","volume":"5","author":"Weng","year":"2025","journal-title":"ACS Meas. Sci. Au"},{"key":"2026092208062423600_cit46","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1021\/acs.analchem.4c06117","article-title":"Exploring\nthe Chiral Match\u2013Mismatch Effect in the Chiral Discrimination\nof Nitriles","volume":"97","author":"Gu","year":"2025","journal-title":"Anal. Chem."},{"key":"2026092208062423600_cit47","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1021\/acscentsci.5c00498","article-title":"High-Throughput 19F NMR\nChiral Analysis\nfor Screening and Directed Evolution of Imine Reductases","volume":"11","author":"Song","year":"2025","journal-title":"ACS Cent. Sci."},{"key":"2026092208062423600_cit48","doi-asserted-by":"publisher","first-page":"4021","DOI":"10.1021\/om050239u","article-title":"Enantiomeric Analysis of Planar Chiral (\u03b76-Arene)chromium\nTricarbonyl Complexes using NMR in Oriented Solvents","volume":"24","author":"Lafon","year":"2005","journal-title":"Organometallics"},{"key":"2026092208062423600_cit49","doi-asserted-by":"publisher","first-page":"33634","DOI":"10.1021\/jacs.5c09152","article-title":"A Highly Versatile Enantiodifferentiating\nPolyglutamate Alignment Medium to Measure Residual Dipolar Couplings\nin Non-Polar and Polar Solvents","volume":"147","author":"Laux","year":"2025","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026092208062423600_cit50","doi-asserted-by":"publisher","first-page":"18850","DOI":"10.1021\/acs.analchem.3c04240","article-title":"Polyarylisocyanides Derived from\nan Alkyne-Pd(II) Catalyst as Robust Alignment Media with Excellent\nEnantiodiscimination","volume":"95","author":"Li","year":"2023","journal-title":"Anal. Chem."},{"key":"2026092208062423600_cit51","doi-asserted-by":"publisher","first-page":"6520","DOI":"10.1021\/ja00129a015","article-title":"Enantiomeric\nanalysis in a polypeptide lyotropic liquid crystal by deuterium NMR","volume":"117","author":"Canet","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"2026092208062423600_cit52","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1021\/ol202547y","article-title":"Polyisocyanides As a New Alignment Medium To Measure\nResidual Dipolar Couplings for Small Organic Molecules","volume":"14","author":"Dama","year":"2012","journal-title":"Org. Lett."},{"key":"2026092208062423600_cit53","doi-asserted-by":"publisher","first-page":"4819","DOI":"10.1021\/acs.orglett.3c01525","article-title":"Chiral Discrimination\nof Nitrile Compounds Using a 19F-Labeled\nPalladium Probe","volume":"25","author":"Gu","year":"2023","journal-title":"Org. Lett."},{"key":"2026092208062423600_cit54","doi-asserted-by":"publisher","first-page":"19770","DOI":"10.1021\/jacs.5c03446","article-title":"One-Pot Multisubstrate Screening\nfor Asymmetric Catalysis Enabled by 19F NMR-Based Simultaneous\nChiral Analysis","volume":"147","author":"Kim","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"2026092208062423600_cit55","doi-asserted-by":"publisher","first-page":"5082","DOI":"10.1039\/D4CC01313A","article-title":"A High-Performance\nchiral 19F-labeled probe with an increased structural twisting","volume":"60","author":"Wang","year":"2024","journal-title":"Chem. Commun."},{"key":"2026092208062423600_cit56","doi-asserted-by":"publisher","first-page":"19240","DOI":"10.1039\/D5NJ03288A","article-title":"Enantiodifferentiation\nof chiral hydroxy acids via19F NMR","volume":"49","author":"Zeng","year":"2025","journal-title":"New J. Chem."},{"key":"2026092208062423600_cit57","doi-asserted-by":"publisher","first-page":"22986","DOI":"10.1021\/acs.analchem.5c05583","article-title":"19F NMR-Guided\nChiral Analysis and Machine Learning for\nAbsolute Configuration Prediction of Carboxylic Acids","volume":"97","author":"Lu","year":"2025","journal-title":"Anal. Chem."},{"key":"2026092208062423600_cit58","doi-asserted-by":"publisher","first-page":"7853","DOI":"10.1021\/acs.analchem.2c00218","article-title":"Simultaneous Discrimination and Quantification\nof Enantiomeric Amino Acids under Physiological Conditions by Chiral 19F NMR Tag","volume":"94","author":"Chen","year":"2022","journal-title":"Anal. Chem."},{"key":"2026092208062423600_cit59","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1021\/jacsau.2c00661","article-title":"Chirality\nSensing of N-Heterocycles via 19F NMR","volume":"3","author":"Gu","year":"2023","journal-title":"JACS Au"},{"key":"2026092208062423600_cit60","doi-asserted-by":"publisher","first-page":"100100","DOI":"10.1016\/j.xcrp.2020.100100","article-title":"Separation-Free\nEnantiodifferentiation with Chromatogram-like Output","volume":"1","author":"Li","year":"2020","journal-title":"Cell Rep. Phys. Sci."},{"key":"2026092208062423600_cit61","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1021\/acs.analchem.1c03783","article-title":"Construction of Lewis\nPairs for Optimal Enantioresolution via Recognition-Enabled \u201cChromatographic\u201d 19F NMR Spectroscopy","volume":"94","author":"Li","year":"2022","journal-title":"Anal. Chem."},{"key":"2026092208062423600_cit62","doi-asserted-by":"publisher","first-page":"7569","DOI":"10.1021\/acs.analchem.3c00049","article-title":"Tailoring the Recognition Property\nof a 19F-Labeled Gallium-Based NMR Probe: The Influence\nof the Metal Center","volume":"95","author":"Liang","year":"2023","journal-title":"Anal. Chem."},{"key":"2026092208062423600_cit63","doi-asserted-by":"publisher","first-page":"3023","DOI":"10.1021\/acs.orglett.3c00816","article-title":"Copper-Catalyzed Enantioselective\nDecarboxylative Cyanation of Benzylic Acids Promoted by Hypervalent\nIodine(III) Reagents","volume":"25","author":"Li","year":"2023","journal-title":"Org. Lett."},{"key":"2026092208062423600_cit64","doi-asserted-by":"publisher","DOI":"10.1002\/chem.71122","article-title":"Chiral Analysis for\nHigh-Throughput Reaction Screening: Recent Advances\nin Accelerating Asymmetric Catalysis Discovery","volume":"32","author":"Yu","year":"2026","journal-title":"Chem.\u2500Eur. J."}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.6c04189","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/37\/27558\/68454668\/acs.analchem.6c04189.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/37\/27558\/68454668\/acs.analchem.6c04189.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:30:31Z","timestamp":1790080231000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancham\/article\/98\/37\/27558\/5426721\/A-Fluorinated-Cyclorhodium-Probe-Enables"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":64,"journal-issue":{"issue":"37","published-online":{"date-parts":[[2026,9,9]]},"published-print":{"date-parts":[[2026,9,22]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.6c04189","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]}}}