{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:16:14Z","timestamp":1788218174962,"version":"build-2803163510"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["B2025105025"],"award-info":[{"award-number":["B2025105025"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2025CX01014"],"award-info":[{"award-number":["2025CX01014"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22322403"],"award-info":[{"award-number":["22322403"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22574013"],"award-info":[{"award-number":["22574013"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["L2612013"],"award-info":[{"award-number":["L2612013"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Single-cell capture and separation in microfluidics requires simultaneous optimization of distinct cascade processes: 1) precise interaction regulation enabling rapid point-to-point recognition, and 2) face-to-face interfacial contact, which determines binding stability and duration. Since these two processes occur on different length scales, constructing an engineered affinity interface that couples both remains highly challenging. Herein, we report a dynamic microfluidic single-cell capture platform that integrates peptide-based rapid recognition interfaces with kinetically matched fluid-field regulation. A series of targeting peptides toward PD-L1 (programmed cell death ligand-1) with antiparallel \u03b2-sheet structure were rationally engineered, leading to an optimized sequence (EAF) characterized by flexible recognition termini and electrostatically dominated binding. At the molecular level, this promotes rapid and specific point-to-point recognition. Upon self-assembly, EAF forms nanofibers densely displaying recognition motifs, thereby enhancing multipoint specific interactions with the cell membrane. By coupling this with a reciprocating-flow microfluidic design, locally perturbed fluidic fields are generated to enhance cell-surface contact, thereby achieving stable binding. This synergistic kinetic modulation facilitates rapid target recognition and stable interfacial binding, resulting in efficient and sustained single-cell capture. Collectively, this work demonstrates a generalizable strategy for engineering dynamic affinity interfaces that align molecular recognition kinetics with microfluidic control, offering a versatile platform for single-cell isolation.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c04313","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:02:50Z","timestamp":1786546970000},"page":"24533-24544","source":"Crossref","is-referenced-by-count":0,"title":["Single-Cell\nRecognition and Separation via Matched\nReciprocating-Flow Interfaces and Peptide Recognition Dynamics"],"prefix":"10.1021","volume":"98","author":[{"given":"Kai","family":"Han","sequence":"first","affiliation":[{"name":"Beijing Institute of Technology , , ,","place":["Beijing, PR China, 100081"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Technology , , ,","place":["Beijing, PR China, 100081"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinsong","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing Institute of Technology , , ,","place":["Beijing, PR China, 100081"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingrui","family":"Deng","sequence":"additional","affiliation":[{"name":"Beijing Institute of Technology , , ,","place":["Beijing, PR China, 100081"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyi","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Ohio State University , , , ,","place":["Columbus, Ohio, United States, OH43210"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinge","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Institute of Technology , , ,","place":["Beijing, PR China, 100081"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0176-1798","authenticated-orcid":true,"given":"Limin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Technology , , ,","place":["Beijing, PR China, 100081"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beilei","family":"Sun","sequence":"additional","affiliation":[{"name":"Beijing Institute of Technology , , ,","place":["Beijing, PR China, 100081"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Miao","sequence":"additional","affiliation":[{"name":"Beijing Institute of Technology , , ,","place":["Beijing, PR China, 100081"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Technology , , ,","place":["Beijing, PR China, 100081"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqing","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Institute of Technology , , ,","place":["Beijing, PR China, 100081"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bokai","family":"Ma","sequence":"additional","affiliation":[{"name":"Beijing Academy of Science and Technology (Beijing Center for Physical and Chemical Analysis) , , ,","place":["Beijing, PR China, 100089"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Technology , , ,","place":["Beijing, PR China, 100081"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7310-4068","authenticated-orcid":true,"given":"Weizhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Technology , , ,","place":["Beijing, PR China, 100081"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"issue":"1","key":"2026083118453557300_cit1","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41467-024-55140-x","article-title":"Tumor cell-based liquid biopsy using high-throughput\nmicrofluidic enrichment of entire leukapheresis product","volume":"16","author":"Mishra","year":"2025","journal-title":"Nat. Commun."},{"issue":"5","key":"2026083118453557300_cit2","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/s41571-020-00457-x","article-title":"Liquid biopsy enters\nthe clinic-implementation issues and future\nchallenges","volume":"18","author":"Ignatiadis","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"41","key":"2026083118453557300_cit3","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202500975","article-title":"Advanced microfluidics\nfor single cell-based cancer research","volume":"12","author":"Carneiro","year":"2025","journal-title":"Adv.\nSci."},{"issue":"12","key":"2026083118453557300_cit4","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1038\/s41556-018-0236-7","article-title":"Tumour heterogeneity\nand metastasis at single-cell resolution","volume":"20","author":"Lawson","year":"2018","journal-title":"Nat.\nCell Biol."},{"issue":"8","key":"2026083118453557300_cit5","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1056\/NEJMoa040766","article-title":"Circulating tumor cells, disease progression,\nand survival in metastatic\nbreast cancer","volume":"351","author":"Cristofanilli","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"14","key":"2026083118453557300_cit6","doi-asserted-by":"publisher","first-page":"4245","DOI":"10.1039\/C7CS00016B","article-title":"Materials and microfluidics: enabling the efficient isolation and\nanalysis of circulating tumour cells","volume":"46","author":"Jackson","year":"2017","journal-title":"Chem.\nSoc. Rev."},{"issue":"2","key":"2026083118453557300_cit7","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/nrn2059","article-title":"Lipid raft microdomains and neurotransmitter signalling","volume":"8","author":"Allen","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"issue":"6","key":"2026083118453557300_cit8","doi-asserted-by":"publisher","first-page":"3280","DOI":"10.1021\/ac303628j","article-title":"Implementing enzyme-linked\nimmunosorbent assays on a microfluidic\nchip to quantify intracellular molecules in single cells","volume":"85","author":"Eyer","year":"2013","journal-title":"Anal. Chem."},{"issue":"7101","key":"2026083118453557300_cit9","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/nature05058","article-title":"The origins\nand the future of microfluidics","volume":"442","author":"Whitesides","year":"2006","journal-title":"Nature"},{"issue":"8","key":"2026083118453557300_cit10","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1002\/anie.201809337","article-title":"Bioinspired engineering of a multivalent aptamer-functionalized nanointerface\nto enhance the capture and release of circulating tumor cells","volume":"58","author":"Song","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"issue":"7173","key":"2026083118453557300_cit11","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1038\/nature06385","article-title":"Isolation of rare circulating\ntumour cells in cancer patients by\nmicrochip technology","volume":"450","author":"Nagrath","year":"2007","journal-title":"Nature"},{"issue":"23","key":"2026083118453557300_cit12","doi-asserted-by":"publisher","first-page":"7606","DOI":"10.1002\/anie.201901412","article-title":"Integration of lateral\nfilter arrays with immunoaffinity for circulating-tumor-cell\nisolation","volume":"58","author":"Chen","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"issue":"49","key":"2026083118453557300_cit13","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202312581","article-title":"Hierarchical\nfluid interface enables spatiotemporal regulation of ligand distribution\nto increase kinetics and thermodynamics of interfacial binding reaction","volume":"62","author":"Niu","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"issue":"21","key":"2026083118453557300_cit14","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202215337","article-title":"A fluid\nmultivalent magnetic interface for high-performance isolation and\nproteomic profiling of tumor-derived extracellular vesicles","volume":"62","author":"Niu","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"issue":"27","key":"2026083118453557300_cit15","doi-asserted-by":"publisher","first-page":"8633","DOI":"10.1021\/ja8015022","article-title":"Highly efficient circulating tumor cell isolation from whole blood\nand label-free enumeration using polymerbased microfluidics with an\nintegrated conductivity sensor","volume":"130","author":"Adams","year":"2008","journal-title":"J. Am. Chem.\nSoc."},{"issue":"3","key":"2026083118453557300_cit16","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1016\/S0006-3495(99)77291-7","article-title":"The forward rate of binding of surface-tethered reactants:\neffect of relative motion between two surfaces","volume":"76","author":"Chang","year":"1999","journal-title":"Biophys. J."},{"issue":"43","key":"2026083118453557300_cit17","doi-asserted-by":"publisher","first-page":"18392","DOI":"10.1073\/pnas.1012539107","article-title":"Isolation of circulating tumor cells using\na microvortex-generating\nherringbone-chip","volume":"107","author":"Stott","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.\nS. A."},{"issue":"36","key":"2026083118453557300_cit18","doi-asserted-by":"publisher","first-page":"10681","DOI":"10.1002\/anie.201702675","article-title":"Isolation, detection, and antigen-based profiling of circulating\ntumor cells using a size-dictated immunocapture chip","volume":"56","author":"Ahmed","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"issue":"547","key":"2026083118453557300_cit19","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaz2878","article-title":"Molecular\nand functional extracellular vesicle analysis using nanopatterned\nmicrochips monitors tumor progression and metastasis","volume":"12","author":"Zhang","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"44","key":"2026083118453557300_cit20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2213236119","article-title":"Fluid\nnanoporous microinterface enables multiscale-enhanced affinity interaction\nfor tumor-derived extracellular vesicle detection","volume":"119","author":"Niu","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"20","key":"2026083118453557300_cit21","doi-asserted-by":"publisher","first-page":"7539","DOI":"10.1039\/C7CS00735C","article-title":"Peptide supramolecular materials for therapeutics","volume":"47","author":"Sato","year":"2018","journal-title":"Chem. Soc. Rev."},{"issue":"16","key":"2026083118453557300_cit22","doi-asserted-by":"publisher","first-page":"6936","DOI":"10.1039\/D2CS00122E","article-title":"Microfabrication of\npeptide self-assemblies: inspired by nature towards\napplications","volume":"51","author":"Zhang","year":"2022","journal-title":"Chem. Soc. Rev."},{"issue":"8","key":"2026083118453557300_cit23","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.1039\/D2CS00675H","article-title":"Functional chromopeptide\nnanoarchitectonics: molecular design, self-assembly\nand biological applications","volume":"52","author":"Chang","year":"2023","journal-title":"Chem. Soc. Rev."},{"issue":"3","key":"2026083118453557300_cit24","doi-asserted-by":"publisher","first-page":"2306676","DOI":"10.1002\/adma.202306676","article-title":"Inhibiting\nendothelial cell-mediated T lymphocyte apoptosis with integrin-targeting\npeptide-drug conjugate filaments for chemoimmunotherapy of triple-negative\nbreast cancer","volume":"36","author":"Cai","year":"2024","journal-title":"Adv. Mater."},{"issue":"2","key":"2026083118453557300_cit25","doi-asserted-by":"publisher","first-page":"1806058","DOI":"10.1002\/adfm.201806058","article-title":"From nanofibers to nanorods: nanostructure of peptide-drug conjugates\nregulated by polypeptide-PEG derivative and enhanced antitumor effect","volume":"29","author":"Chen","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"2026083118453557300_cit26","doi-asserted-by":"publisher","first-page":"215530","DOI":"10.1016\/j.ccr.2023.215530","article-title":"Peptide-nanoparticle\nconjugates as a theranostic platform","volume":"500","author":"Kim","year":"2024","journal-title":"Coord.\nChem. Rev."},{"issue":"1","key":"2026083118453557300_cit27","doi-asserted-by":"publisher","first-page":"5940","DOI":"10.1038\/ncomms6940","article-title":"Profiling lymphocyte\ninteractions at the single-cell level by microfluidic\ncell pairing","volume":"6","author":"Dura","year":"2015","journal-title":"Nat. Commun."},{"issue":"2","key":"2026083118453557300_cit28","doi-asserted-by":"publisher","first-page":"022206","DOI":"10.1063\/1.3576780","article-title":"High-throughput size-based\nrare cell enrichment using microscale vortices","volume":"5","author":"Hur","year":"2011","journal-title":"Biomicrofluidics"},{"issue":"8","key":"2026083118453557300_cit42","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1021\/jo00008a012","article-title":"[(9-Fluorenylmethyl)oxy]carbonyl\n(Fmoc) amino acid chlorides in solid-phase\npeptide synthesis","volume":"56","author":"Carpino","year":"1991","journal-title":"J. Org. Chem."},{"issue":"43","key":"2026083118453557300_cit43","doi-asserted-by":"publisher","first-page":"9954","DOI":"10.1021\/jp003020w","article-title":"Structure and dynamics of the TIP3P, SPC, and SPC\/E\nwater models at 298 K","volume":"105","author":"Mark","year":"2001","journal-title":"J. Phys. Chem. A"},{"issue":"1","key":"2026083118453557300_cit29","doi-asserted-by":"publisher","first-page":"5736","DOI":"10.1038\/s41467-020-18859-x","article-title":"Polyelectrolyte interactions\nenable rapid association and dissociation in high-affinity disordered\nprotein complexes","volume":"11","author":"Sottini","year":"2020","journal-title":"Nat. Commun."},{"issue":"2","key":"2026083118453557300_cit30","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1006\/jmbi.1999.2615","article-title":"Predicting the rate enhancement of\nprotein complex\nformation from the electrostatic energy of interaction","volume":"287","author":"Selzer","year":"1999","journal-title":"J. Mol. Biol."},{"issue":"24","key":"2026083118453557300_cit31","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1021\/acs.biochem.9b00231","article-title":"Enhancement\nof RNA\/ligand association kinetics via\nan electrostatic anchor","volume":"58","author":"Sengupta","year":"2019","journal-title":"Biochemistry"},{"issue":"1","key":"2026083118453557300_cit32","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1021\/acsnano.5b06011","article-title":"Electrostatic-driven\nlamination and untwisting of \u03b2-sheet assemblies","volume":"10","author":"Hu","year":"2016","journal-title":"ACS Nano"},{"issue":"5238","key":"2026083118453557300_cit33","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1126\/science.270.5238.980","article-title":"Guidelines for protein design: the energetics of \u03b2 sheet side\nchain interactions","volume":"270","author":"Smith","year":"1995","journal-title":"Science"},{"issue":"15","key":"2026083118453557300_cit34","doi-asserted-by":"publisher","first-page":"5477","DOI":"10.1021\/ja3088407","article-title":"The supramolecular chemistry\nof \u03b2-sheets","volume":"135","author":"Cheng","year":"2013","journal-title":"J. Am. Chem. Soc."},{"issue":"47","key":"2026083118453557300_cit35","doi-asserted-by":"publisher","first-page":"14052","DOI":"10.1039\/D2SC02728C","article-title":"Peptide nano \u2018bead-grafting\u2019\nfor SDT-facilitated immune\ncheckpoints blocking","volume":"13","author":"Zhang","year":"2022","journal-title":"Chem. Sci."},{"issue":"2","key":"2026083118453557300_cit36","doi-asserted-by":"publisher","first-page":"2207330","DOI":"10.1002\/adma.202207330","article-title":"A totipotent \u201cAll-In-One\u201d\npeptide sequentially blocks\nimmune checkpoint and reverses the immunosuppressive tumor microenvironment","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv. Mater."},{"issue":"2","key":"2026083118453557300_cit37","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1021\/nn102278w","article-title":"Evaluation of multivalent,\nfunctional polymeric nanoparticles for\nimaging applications","volume":"5","author":"Shokeen","year":"2011","journal-title":"ACS Nano"},{"issue":"3","key":"2026083118453557300_cit38","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nnano.2008.30","article-title":"Nanoparticle-mediated\ncellular response is size-dependent","volume":"3","author":"Jiang","year":"2008","journal-title":"Nat. Nanotechnol."},{"issue":"4","key":"2026083118453557300_cit39","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/nrc3239","article-title":"The blockade\nof immune checkpoints in cancer immunotherapy","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"2026083118453557300_cit40","doi-asserted-by":"publisher","first-page":"171728","DOI":"10.1016\/j.cej.2025.171728","article-title":"A pulsatile acoustofluidic platform inducing chaotic flow for enhanced\nmixing, molecular interactions and particle manipulation in single-phase\nand droplet microfluidics","volume":"527","author":"Vardin","year":"2026","journal-title":"Chem. Eng. J."},{"issue":"10","key":"2026083118453557300_cit41","doi-asserted-by":"publisher","first-page":"2802","DOI":"10.1039\/D4LC00184B","article-title":"Microfluidic confined\nacoustic streaming vortex for liposome synthesis","volume":"24","author":"Xu","year":"2024","journal-title":"Lab Chip"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.6c04313","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/33\/24533\/66513926\/acs.analchem.6c04313.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/33\/24533\/66513926\/acs.analchem.6c04313.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:45:48Z","timestamp":1788216348000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancham\/article\/98\/33\/24533\/5253606\/Single-Cell-Recognition-and-Separation-via-Matched"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":43,"journal-issue":{"issue":"33","published-online":{"date-parts":[[2026,8,12]]},"published-print":{"date-parts":[[2026,8,25]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.6c04313","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]}}}