{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:14:51Z","timestamp":1790082891753,"version":"4.0.1"},"reference-count":25,"publisher":"American Chemical Society (ACS)","issue":"37","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["10.55776\/PIN3635824"],"award-info":[{"award-number":["10.55776\/PIN3635824"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inductively coupled plasma mass spectrometry (ICPMS) is gaining increasing recognition for speciation analysis of nonmetals, but many compounds, such as those containing halogens and sulfur, are highly hydrophobic, requiring the use of the organic ICPMS mode to address compatibility with reversed-phase liquid chromatography. Herein, we introduce 2-butoxyethanol (BE) as a novel eluent with exceptional elution strength and plasma tolerability. BE allows operation under standard conditions used with 100% aqueous mobile phases, with no plasma shutdown or carbon buildup. Direct comparison with methanol when used under the organic ICPMS mode showed superior sensitivity by 3-5-fold despite the employment of highly optimized and mild organic mode conditions. BE concentrations \u226430 v\/v remarkably provided an elution strength matching that of 90\u2013100% v\/v methanol, which was demonstrated in multiple proof-of-concept applications involving the elution of highly hydrophobic analytes from a reversed-phase C18 column. These included separation of a complex mixture of polychlorinated biphenyls (PCBs) where superior resolution and unique chromatographic selectivity were found, as well as arsenolipid screening in seaweed, where highly complex profiles in various edible species were observed, revealing &amp;gt;100 signals at instrumental LOD down to 6 ng As L\u20131 (20 \u03bcL injection volume). The introduced eluent presents a significant advancement over previous work, including yet stronger elution than that achievable with 1,2 hexanediol at lower column backpressure, providing a major step forward in optimizing the practice of reversed-phase liquid chromatography to suit the changing demands of speciation analysis.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c04370","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:01:21Z","timestamp":1789056081000},"page":"27585-27592","source":"Crossref","is-referenced-by-count":0,"title":["Butoxyethanol:\nA Novel and Exceptionally Strong Eluent\nfor ICPMS Detection Eliminating the Organic Mode"],"prefix":"10.1021","volume":"98","author":[{"given":"Julia","family":"Truschner","sequence":"first","affiliation":[{"name":"University of Graz , , Universitaetsplatz 1 , ,","place":["Graz, Austria, 8010"]},{"name":"University of Graz , , Universitaetsplatz 1 , ,","place":["Graz, Austria, 8010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Goessler","sequence":"additional","affiliation":[{"name":"University of Graz , , Universitaetsplatz 1 , ,","place":["Graz, Austria, 8010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5717-1201","authenticated-orcid":true,"given":"Bassam","family":"Lajin","sequence":"additional","affiliation":[{"name":"University of Graz , , Universitaetsplatz 1 , ,","place":["Graz, Austria, 8010"]},{"name":"University of Graz , , Universitaetsplatz 1 , ,","place":["Graz, Austria, 8010"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"2026092208081605700_cit1","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s00216-017-0502-8","article-title":"Importance of ICPMS for speciation\nanalysis is changing: future trends for targeted and non-targeted\nelement speciation analysis","volume":"410","author":"Feldmann","year":"2018","journal-title":"Anal. Bioanal.\nChem."},{"key":"2026092208081605700_cit2","doi-asserted-by":"publisher","first-page":"5851","DOI":"10.1021\/ac3009516","article-title":"Triple quad\nICPMS (ICPQQQ) as a new tool for absolute quantitative proteomics\nand phosphoproteomics","volume":"84","author":"Ferna\u0301ndez","year":"2012","journal-title":"Anal. Chem."},{"key":"2026092208081605700_cit3","doi-asserted-by":"publisher","first-page":"9156","DOI":"10.1021\/acs.analchem.0c01456","article-title":"Simultaneous Determination\nof Chlorinated and Brominated\nAcetic Acids in Various Environmental Water Matrixes by High-Performance\nLiquid Chromatography\u2013Inductively Coupled Plasma Tandem Mass\nSpectrometry without Sample Preparation","volume":"92","author":"Lajin","year":"2020","journal-title":"Anal.\nChem."},{"key":"2026092208081605700_cit4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.aca.2019.05.064","article-title":"Biological\nsulphur-containing compounds\u2013Analytical\nchallenges","volume":"1079","author":"Raab","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"2026092208081605700_cit5","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.aca.2015.03.049","article-title":"Introduction of organic\/hydro-organic\nmatrices in inductively coupled plasma optical emission spectrometry\nand mass spectrometry: a tutorial review. Part I. Theoretical considerations","volume":"885","author":"Leclercq","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"2026092208081605700_cit6","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1039\/D0JA00525H","article-title":"Introducing dimethyl carbonate as\na new eluent in HPLC-ICPMS:\nstronger elution with less carbon","volume":"36","author":"Lajin","year":"2021","journal-title":"J. Anal.\nAt. Spectrom."},{"key":"2026092208081605700_cit7","doi-asserted-by":"publisher","first-page":"13361","DOI":"10.1021\/acs.analchem.5c01663","article-title":"Controllable Ion-Repulsion\nEnables Rapid and Trace-Level\nDetection of Hydrophobic Sulfonylurea Herbicides with ICPMS\/MS without\nthe Organic Mode","volume":"97","author":"Lajin","year":"2025","journal-title":"Anal. Chem."},{"key":"2026092208081605700_cit8","doi-asserted-by":"publisher","first-page":"8706","DOI":"10.1021\/acs.analchem.3c01364","article-title":"Determination of Phosphoethanolamine\nin Urine with\nHPLC-ICPMS\/ MS Using 1,2-Hexanediol as a Chromatographic Eluent","volume":"95","author":"Lajin","year":"2023","journal-title":"Anal. Chem."},{"key":"2026092208081605700_cit9","doi-asserted-by":"publisher","first-page":"8802","DOI":"10.1021\/acs.analchem.2c01769","article-title":"Elution with 1, 2-hexanediol\nenables\ncoupling of ICPMS with reversed-phase liquid chromatography under\nstandard conditions","volume":"94","author":"Lajin","year":"2022","journal-title":"Anal. Chem."},{"key":"2026092208081605700_cit10","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1021\/es00169a004","article-title":"Octanol-water\npartition coefficients of polychlorinated\nbiphenyl congeners","volume":"22","author":"Hawker","year":"1988","journal-title":"Environ. Sci. Technol."},{"key":"2026092208081605700_cit11","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1194\/jlr.D700041-JLR200","article-title":"Lipid extraction by methyl-tert-butyl\nether for high-throughput\nlipidomics","volume":"49","author":"Matyash","year":"2008","journal-title":"J. Lipid Res."},{"key":"2026092208081605700_cit12","doi-asserted-by":"publisher","first-page":"4662","DOI":"10.1021\/jp9629351","article-title":"Calorimetric study\nof the micellization of n-butoxyethanol\nin water","volume":"101","author":"Onori","year":"1997","journal-title":"J. Phys. Chem. B"},{"key":"2026092208081605700_cit13","unstructured":"International Programme on Chemical Safety: 2-Butoxyethanol\n          World Health Organization: Geneva; 1998."},{"key":"2026092208081605700_cit14","unstructured":"Document\nfor Proposed Designation of 1,2-Hexanediol (CASRN 6920-22-5)\n          U.S. Environmental Protection Agency: Washington, DC; 2020."},{"key":"2026092208081605700_cit15","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1039\/JA9940901099","article-title":"Carbon-enhanced\ninductively coupled plasma mass spectrometric\ndetection of arsenic and selenium and its application to arsenic speciation","volume":"9","author":"Larsen","year":"1994","journal-title":"J. Anal. At. Spectrom."},{"key":"2026092208081605700_cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.124781","article-title":"Variation\nin arsenolipid concentrations in seafood consumed in Japan","volume":"239","author":"Al Amin","year":"2020","journal-title":"Chemosphere"},{"key":"2026092208081605700_cit17","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1039\/C1JA10260E","article-title":"A method\nfor screening arsenolipids in fish oils by HPLC-ICPMS","volume":"27","author":"Ruiz-Chancho","year":"2012","journal-title":"J. Anal. At. Spectrom."},{"key":"2026092208081605700_cit18","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1021\/jf204595d","article-title":"Application of HPLC-ICP-MS and HPLC-ESI-MS procedures\nfor arsenic speciation in seaweeds","volume":"60","author":"Hsieh","year":"2012","journal-title":"J. Agric.\nFood Chem."},{"key":"2026092208081605700_cit19","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1016\/j.scitotenv.2018.10.102","article-title":"Arsenic speciation\nin aerosols of\na respiratory therapeutic cave: A first approach to study arsenicals\nin ultrafine particles","volume":"651","author":"Tanda","year":"2019","journal-title":"Sci. Total Environ."},{"key":"2026092208081605700_cit20","doi-asserted-by":"publisher","first-page":"5532","DOI":"10.1021\/acs.est.9b07707","article-title":"Occurrence,\nseasonal variation, and size resolved distribution of arsenic species\nin atmospheric particulate matter in an urban area in Southeastern\nAustria","volume":"54","author":"Tanda","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"2026092208081605700_cit21","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.1021\/ac303340t","article-title":"Comprehensive\nanalysis of lipophilic arsenic species in a brown alga (Saccharina\nlatissima)","volume":"85","author":"Raab","year":"2013","journal-title":"Anal. Chem."},{"key":"2026092208081605700_cit22","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1039\/b402561j","article-title":"Arsenic\nspeciation in commercially available peanut butter spread by IC-ICP-MS","volume":"19","author":"Hovanec","year":"2004","journal-title":"J. Anal. At. Spectrom."},{"key":"2026092208081605700_cit23","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/0731-7085(95)01501-B","article-title":"The determination\nof palladium in fosinopril sodium (monopril) by ICP-MS","volume":"13","author":"Lewen","year":"1995","journal-title":"J. Pharm. Biomed. Anal."},{"key":"2026092208081605700_cit24","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s10532-020-09900-3","article-title":"Isolation and characterization\nof\n2-butoxyethanol degrading bacterial strains","volume":"31","author":"Woiski","year":"2020","journal-title":"Biodegradation"},{"key":"2026092208081605700_cit25","first-page":"396","article-title":"The Limiting\nCritical Solution Temperature of the 2-Butoxyethanol\u2013Water\nSystem","volume":"12","author":"Ellis","year":"1967","journal-title":"J. Chem. Eng. Data"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.6c04370","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/37\/27585\/68474447\/acs.analchem.6c04370.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/37\/27585\/68474447\/acs.analchem.6c04370.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:49:28Z","timestamp":1790081368000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancham\/article\/98\/37\/27585\/5427830\/Butoxyethanol-A-Novel-and-Exceptionally-Strong"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":25,"journal-issue":{"issue":"37","published-online":{"date-parts":[[2026,9,10]]},"published-print":{"date-parts":[[2026,9,22]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.6c04370","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]}}}