{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:07:47Z","timestamp":1790690867668,"version":"4.1.0"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U2341290"],"award-info":[{"award-number":["U2341290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mitophagy is essential for mitochondrial quality control and cellular homeostasis, while its aberrant hyperactivation has emerged as a promising strategy to selectively eliminate cancer cells. This process depends on the adenosine triphosphate (ATP) interplay between mitochondria and lysosomes, yet probes that simultaneously enable dual-organelle ATP imaging and mitophagy regulation are still lacking. Herein, we report MLA, a powerful fluorescent probe that integrates spectrally resolved ATP imaging in both organelles with inducible excessive mitophagy. Bearing pH-adapted fluorophores and a glutathione (GSH)-cleavable disulfide, MLA operates in two modes: at low doses, it serves as a biocompatible reporter to map ATP fluctuations under various perturbations; at high doses, it depletes mitochondrial GSH, thereby triggering a reactive oxygen species (ROS) burst that induces excessive mitophagy and cancer cell death. Mechanistically, it was discovered that this process consumes the transmembrane glycoprotein Mucin 1 (MUC1) whose degradation blocks autophagic flux, and thus leads to lethal accumulation of undegraded autophagosomes, markedly suppressing proliferation. In vivo, MLA enables specific imaging of intratumoral ATP and exhibits tumor-inhibitory capacity. Co-administration with the ATP synthase inhibitor oligomycin A (Omy A) further amplifies the tumor-suppressive effect, validating a simultaneous and drastic ATP\/GSH dual-depletion strategy as a feasible combination therapy. MLA represents the first fluorescent probe to synergize dual-organelle ATP imaging with mitophagy regulation, offering a powerful tool for fundamental research and a new paradigm for the design of versatile fluorescent probes.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c04402","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:02:17Z","timestamp":1789578137000},"page":"28495-28510","source":"Crossref","is-referenced-by-count":0,"title":["Simultaneous\nand Real-Time Imaging of Mitochondrial\nand Lysosomal ATP with Inducible Excessive Mitophagy for Antitumor\nTherapy via a Multifunctional Fluorescent Probe"],"prefix":"10.1021","volume":"98","author":[{"given":"Zhou","family":"Wu","sequence":"first","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9992-7253","authenticated-orcid":true,"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihong","family":"Yao","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0071-8139","authenticated-orcid":true,"given":"Zhihao","family":"Lu","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Li","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemao","family":"Dou","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Zeng","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirong","family":"Geng","sequence":"additional","affiliation":[{"name":"Nanjing University of Chinese Medicine , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8123-1016","authenticated-orcid":true,"given":"Zhilin","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, P. R. China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"2026092909111059500_cit1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrm3028","article-title":"Mechanisms of Mitophagy","volume":"12","author":"Youle","year":"2011","journal-title":"Nat.\nRev. Mol. 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Sci."},{"key":"2026092909111059500_cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119668","article-title":"Mitochondria-Acting\nNanomicelles\nfor Destruction of Cancer Cells via Excessive Mitophagy\/Autophagy-Driven\nLethal Energy Depletion and Phototherapy","volume":"232","author":"Zhu","year":"2020","journal-title":"Biomaterials"},{"key":"2026092909111059500_cit6","doi-asserted-by":"publisher","first-page":"9471","DOI":"10.1021\/acs.analchem.1c01237","article-title":"Monitoring Mitophagy via the FRET\nMechanism: Visualizing Mitochondria, Lysosomes, and Autolysosomes\nin Three Different Sets of Fluorescence Signals","volume":"93","author":"Lu","year":"2021","journal-title":"Anal. Chem."},{"key":"2026092909111059500_cit7","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/nrd.2018.174","article-title":"Mitochondria as a Therapeutic Target for Common Pathologies","volume":"17","author":"Murphy","year":"2018","journal-title":"Nat. Rev. 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Res."}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.6c04402","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/38\/28495\/68535965\/acs.analchem.6c04402.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/38\/28495\/68535965\/acs.analchem.6c04402.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:23:24Z","timestamp":1790688204000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancham\/article\/98\/38\/28495\/5431555\/Simultaneous-and-Real-Time-Imaging-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":47,"journal-issue":{"issue":"38","published-online":{"date-parts":[[2026,9,16]]},"published-print":{"date-parts":[[2026,9,29]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.6c04402","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]}}}