{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:34:40Z","timestamp":1787070880915,"version":"build-2736575974"},"reference-count":29,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100013156","name":"Startup Foundation for Introducing Talent of Nanjing University of Information Science and Technology","doi-asserted-by":"publisher","award":["2023r033"],"award-info":[{"award-number":["2023r033"]}],"id":[{"id":"10.13039\/501100013156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21876068"],"award-info":[{"award-number":["21876068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22422604"],"award-info":[{"award-number":["22422604"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011400","name":"State Key Laboratory of Analytical Chemistry for Life Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011400","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National and Local Joint Engineering Research Center for Mineral Salt Deep Utilization","award":["SF202408"],"award-info":[{"award-number":["SF202408"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A nanochannel-gated bipolar electrode (BPE) that undergoes a target-actuated, dynamic transition from a \u201cclosed\u201d to an \u201copen\u201d state for ultrasensitive biosensing was successfully developed. This electrochemiluminescence (ECL) sensor leverages a target-induced conformational change in aptamers to control the state of an anodized aluminum oxide (AAO) nanochannel membrane, which separates the two chambers of the BPE system. In the initial \u201cclosed\u201d state, the nanochannels are blocked, yielding a high ECL signal. The introduction of the target, deoxynivalenol (DON) toxin, triggers two synergistic inhibition events: it opens the nanochannel gate, transitioning the system to an \u201copen\u201d BPE state that allows a quencher (ascorbic acid) to access the luminophore, and it simultaneously increases the impedance at the BPE cathode, affecting electron transfer. This combination of system state-switching and internal impedance modulation results in a profound signal suppression, leading to a high detection sensitivity. The sensor achieved a detection limit of 0.24 pg\u00b7mL\u20131 for DON over a wide dynamic range. This work presents a new paradigm for biosensor design, moving from static configurations to dynamically reconfigurable electrochemical systems.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c04446","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:05:30Z","timestamp":1785852330000},"page":"23929-23938","source":"Crossref","is-referenced-by-count":0,"title":["A Bipolar Electrode\nwith a Target-Actuated Closed-to-Open\nState Transition for Synergistic Dual-Inhibition Electrochemiluminescence\nSensing"],"prefix":"10.1021","volume":"98","author":[{"given":"Yi","family":"Zou","sequence":"first","affiliation":[{"name":"Nanjing University of Information Science & Technology , , ,","place":["Nanjing, P. R. China, 210044"]},{"name":"Hefei University of Technology , , ,","place":["Hefei, P. R. 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