{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:16:14Z","timestamp":1788218174094,"version":"build-2803163510"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22264013"],"award-info":[{"award-number":["22264013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Hainan Province Science and Technology Special Fund","doi-asserted-by":"publisher","award":["ZDYF2024SHFZ107"],"award-info":[{"award-number":["ZDYF2024SHFZ107"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Hainan Province Science and Technology Special Fund","doi-asserted-by":"publisher","award":["ZDYF2024SHFZ131"],"award-info":[{"award-number":["ZDYF2024SHFZ131"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As a global health challenge, drug-induced liver injury (DILI) is an acute inflammatory disease closely linked to ferroptosis. Ferroptosis, characterized by iron-dependent lipid peroxidation, has been implicated in diverse pathological conditions, however, its precise molecular mechanism in liver injury remains to be fully elucidated. As a key active nitrogen species, the concentration fluctuation of nitroxyl (HNO) is closely correlated with ferroptosis. Nevertheless, in situ and real-time monitoring of endogenous HNO remains highly challenging owing to its transient lifespan and prominent reactivity. To address this issue, we constructed a near-infrared fluorescent probe specifically activated by HNO to delineate the intrinsic interplay between ferroptosis and DILI, thereby facilitating early diagnosis. This probe features a rapid response rate, extremely specificity, high sensitivity, and outstanding photostability, successfully achieving precise detection and imaging of both exogenous and endogenous HNO in vitro and in vivo. Crucially, real-time monitoring of the dynamic fluctuations of HNO levels with the probe explicitly unveiled a tight correlation of the ferroptosis process with DILI. Notably, inhibiting ferroptosis could significantly alleviate the progression of liver injury. Overall, this work not only provides a powerful molecular tool for the diagnosis of ferroptosis-associated liver diseases, but also offers important theoretical foundations and new strategies for the early clinical intervention of liver injury and related drug screening.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c04503","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:02:24Z","timestamp":1786622544000},"page":"24556-24565","source":"Crossref","is-referenced-by-count":0,"title":["A Near-Infrared\nFluorescent Probe for Imaging Nitroxyl\nDynamics in Ferroptosis-Associated Drug-Induced Liver Injury"],"prefix":"10.1021","volume":"98","author":[{"given":"Xianzhu","family":"Luo","sequence":"first","affiliation":[{"name":"Hainan Medical University , , , ,","place":["Haikou, Hainan, China, 571199"]},{"name":"Hainan Medical University , , ,","place":["Haikou, China, 571199"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxin","family":"Huang","sequence":"additional","affiliation":[{"name":"Hainan Medical University , , , ,","place":["Haikou, Hainan, China, 571199"]},{"name":"Hainan Medical University , , ,","place":["Haikou, China, 571199"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Su","sequence":"additional","affiliation":[{"name":"Hainan Medical University , , , ,","place":["Haikou, Hainan, China, 571199"]},{"name":"Hainan Medical University , , ,","place":["Haikou, China, 571199"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Shen","sequence":"additional","affiliation":[{"name":"Hainan Medical University , , , ,","place":["Haikou, Hainan, China, 571199"]},{"name":"Hainan Medical University , , ,","place":["Haikou, China, 571199"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Hainan Medical University , , , ,","place":["Haikou, Hainan, China, 571199"]},{"name":"Hainan Medical University , , ,","place":["Haikou, China, 571199"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlong","family":"Xing","sequence":"additional","affiliation":[{"name":"Hainan Medical University , , , ,","place":["Haikou, Hainan, China, 571199"]},{"name":"Hainan Medical University , , ,","place":["Haikou, China, 571199"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0073-6299","authenticated-orcid":true,"given":"Fabiao","family":"Yu","sequence":"additional","affiliation":[{"name":"Hainan Medical University , , , ,","place":["Haikou, Hainan, China, 571199"]},{"name":"Hainan Medical University , , ,","place":["Haikou, China, 571199"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"2026083118453650300_cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.38","article-title":"Liver and\nAdipose Tissue Control Uridine Biosynthesis","volume":"13","author":"Greenhill","year":"2017","journal-title":"Nat. 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