{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:43:41Z","timestamp":1792784621904,"version":"4.5.0"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZC20251342"],"award-info":[{"award-number":["GZC20251342"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2026NSFSC1533"],"award-info":[{"award-number":["2026NSFSC1533"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22104100"],"award-info":[{"award-number":["22104100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22504091"],"award-info":[{"award-number":["22504091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NHC Key Laboratory of Cardiopulmonary Rehabilitation and Functional Recovery, University of Health and Rehabilitation Sciences","award":["202605"],"award-info":[{"award-number":["202605"]}],"id":[{"id":"https:\/\/ror.org\/02kjtx631","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Reliable fluorescence analysis of plasma membrane (PM) remodeling is often compromised by probe internalization and intracellular redistribution, which can obscure genuine changes in membrane physicochemical properties. Herein, we report NIR-PMP-1, a near-infrared fluorescent molecular rotor designed for rapid, wash-free, and long-retention PM imaging and analysis. NIR-PMP-1 labels the PM within 30 s, remains predominantly membrane-confined for up to 24 h with minimal internalization, and retains membrane specificity in both live and fixed cells. Comparison with NIR-PMP-2, together with experimentally determined log P values of 0.65 \u00b1 0.08 and 1.20 \u00b1 0.10, respectively, indicates that balanced lipophilicity is critical for persistent membrane retention. Enabled by this stable localization, NIR-PMP-1 visualized progressive PM remodeling during erastin-induced ferroptosis and cholesterol-targeting drug treatments. HPLC\u2013HRMS verified probe integrity, while immunoblotting and lipidomics revealed associated GPX4\/Nrf2 alterations and distinct drug-specific lipid remodeling patterns. The probe further differentiated the tested cancer and normal cell lines in monoculture and coculture. Giant unilamellar vesicle experiments linked its fluorescence response to membrane lipid composition and order, providing mechanistic support for membrane-state discrimination. Collectively, NIR-PMP-1 provides a long-retention fluorescent platform for reliable analysis of dynamic PM remodeling and disease-associated membrane microenvironments.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c05706","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:01:13Z","timestamp":1789696873000},"page":"28608-28616","source":"Crossref","is-referenced-by-count":0,"title":["Long-Retention\nFluorescent Probe for Plasma Membrane\nImaging and Analysis of Membrane Remodeling"],"prefix":"10.1021","volume":"98","author":[{"given":"Yongcheng","family":"Dai","sequence":"first","affiliation":[{"name":"Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chai","sequence":"additional","affiliation":[{"name":"Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610041"]},{"name":"Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaorui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Chen","sequence":"additional","affiliation":[{"name":"Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wu","sequence":"additional","affiliation":[{"name":"Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Gao","sequence":"additional","affiliation":[{"name":"Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7705-2288","authenticated-orcid":true,"given":"Zixuan","family":"Zhan","sequence":"additional","affiliation":[{"name":"Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"2026092909112805100_cit1","doi-asserted-by":"publisher","first-page":"5616","DOI":"10.1038\/s41467-019-13432-7","article-title":"Permeability of Membranes in the\nLiquid Ordered and Liquid Disordered Phases","volume":"10","author":"Ghysels","year":"2019","journal-title":"Nat. Commun."},{"key":"2026092909112805100_cit2","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/nature04396","article-title":"Membrane Curvature\nand Mechanisms of Dynamic Cell Membrane\nRemodelling","volume":"438","author":"McMahon","year":"2005","journal-title":"Nature"},{"key":"2026092909112805100_cit3","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1126\/science.1174621","article-title":"Lipid Rafts as a Membrane-Organizing\nPrinciple","volume":"327","author":"Lingwood","year":"2010","journal-title":"Science"},{"key":"2026092909112805100_cit4","doi-asserted-by":"publisher","first-page":"11875","DOI":"10.1073\/pnas.1301766110","article-title":"Plasma\nMembrane Tension Orchestrates Membrane Trafficking, Cytoskeletal Remodeling,\nand Biochemical Signaling During Phagocytosis","volume":"110","author":"Masters","year":"2013","journal-title":"Proc. Nat. Acad. Sci."},{"key":"2026092909112805100_cit5","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fphys.2013.00024","article-title":"Alzheimer\u2019s\nDisease (AD) as a Disorder of the Plasma Membrane","volume":"4","author":"Lukiw","year":"2013","journal-title":"Front. Physiol."},{"key":"2026092909112805100_cit6","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41421-020-00233-2","article-title":"Plasma Membrane\nIntegrity in Health and Disease: Significance\nand Therapeutic Potential","volume":"7","author":"Dias","year":"2021","journal-title":"Cell Discovery"},{"key":"2026092909112805100_cit7","doi-asserted-by":"publisher","first-page":"217255","DOI":"10.1016\/j.ccr.2025.217255","article-title":"Recent Progress\nof Enzyme-Activated\nSmall-Molecule Fluorescent Probes in Biological Systems","volume":"549","author":"Zhang","year":"2026","journal-title":"Coord. Chem. Rev."},{"key":"2026092909112805100_cit8","doi-asserted-by":"publisher","first-page":"9391","DOI":"10.1039\/D0CS01183E","article-title":"Small-Molecule Fluorescence-Based\nProbes for Interrogating Major Organ Diseases","volume":"50","author":"Han","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"2026092909112805100_cit9","doi-asserted-by":"publisher","first-page":"5846","DOI":"10.1021\/acs.chemrev.3c00819","article-title":"Small-Molecule\nFluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active\nBiological Metals","volume":"124","author":"Grover","year":"2024","journal-title":"Chem. Rev."},{"key":"2026092909112805100_cit10","doi-asserted-by":"publisher","first-page":"11089","DOI":"10.1021\/acs.analchem.2c02312","article-title":"Polarity-Sensitive\nCell Membrane Probe Reveals Lower Polarity of Tumor Cell Membrane\nand Its Application for Tumor Diagnosis","volume":"94","author":"Li","year":"2022","journal-title":"Anal.\nChem."},{"key":"2026092909112805100_cit11","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1021\/acssensors.3c00886","article-title":"Selective\nMolecular Recognition and Indicator Displacement Sensing of Neurotransmitters\nin Cellular Environments","volume":"8","author":"Chen","year":"2023","journal-title":"ACS Sens."},{"key":"2026092909112805100_cit12","doi-asserted-by":"publisher","first-page":"214862","DOI":"10.1016\/j.ccr.2022.214862","article-title":"Small-Molecule\nFluorescent Probes for Plasma Membrane Staining: Design, Mechanisms\nand Biological Applications","volume":"474","author":"Yang","year":"2023","journal-title":"Coord. Chem. Rev."},{"key":"2026092909112805100_cit13","doi-asserted-by":"publisher","first-page":"11238","DOI":"10.1021\/acs.analchem.2c01737","article-title":"Polarity-Sensitive\nand Membrane-Specific Probe Quantitatively Monitoring\nFerroptosis through Fluorescence Lifetime Imaging","volume":"94","author":"Wu","year":"2022","journal-title":"Anal. Chem."},{"key":"2026092909112805100_cit14","doi-asserted-by":"publisher","first-page":"129787","DOI":"10.1016\/j.snb.2021.129787","article-title":"Viscosity\nSensitive Fluorescent Dyes with Excellent Photostability Based on\nHemicyanine Dyes for Targeting Cell Membrane","volume":"337","author":"Wang","year":"2021","journal-title":"Sens. Actuators B: Chem."},{"key":"2026092909112805100_cit15","doi-asserted-by":"publisher","first-page":"5996","DOI":"10.1021\/acs.analchem.2c00574","article-title":"Imaging and Measuring Vesicular Acidification with\na Plasma Membrane-Targeted Ratiometric Ph Probe","volume":"94","author":"Michelis","year":"2022","journal-title":"Anal. Chem."},{"key":"2026092909112805100_cit16","doi-asserted-by":"publisher","first-page":"116092","DOI":"10.1016\/j.trac.2020.116092","article-title":"Advances in the Development of Fluorescence\nProbes for Cell Plasma Membrane Imaging","volume":"133","author":"Liu","year":"2020","journal-title":"TrAC-Trends\nAnal. Chem."},{"key":"2026092909112805100_cit17","doi-asserted-by":"publisher","first-page":"129950","DOI":"10.1016\/j.snb.2021.129950","article-title":"A Water-Soluble Aiegen for Ultrafast\nand Wash-Free Imaging of Plasma Membranes in Biosystems","volume":"340","author":"Hu","year":"2021","journal-title":"Sens. Actuators B: Chem."},{"key":"2026092909112805100_cit18","doi-asserted-by":"publisher","first-page":"14920","DOI":"10.1002\/anie.201907690","article-title":"Switchable\nSolvatochromic Probes for Live-Cell Super-Resolution Imaging of Plasma\nMembrane Organization","volume":"58","author":"Danylchuk","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026092909112805100_cit19","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.1021\/acssensors.4c00486","article-title":"Cell-Impermeable\nBuffering Fluorogenic Probes for Live-Cell Super-Resolution Imaging\nof Plasma Membrane Morphology Dynamics","volume":"9","author":"Zhou","year":"2024","journal-title":"ACS\nSens."},{"key":"2026092909112805100_cit20","doi-asserted-by":"publisher","first-page":"6092","DOI":"10.1021\/acssensors.4c01963","article-title":"Permeability-Controlled\nProbe for Ratiometric Detection of Plasma Membrane Integrity and Late\nApoptosis","volume":"9","author":"Sun","year":"2024","journal-title":"ACS Sens."},{"key":"2026092909112805100_cit21","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202519056","article-title":"Fluorogenic\nRhodamine Probes Enable High-Resolution Visualization of Plasma Membrane\nNanostructures","volume":"65","author":"Luo","year":"2026","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026092909112805100_cit22","doi-asserted-by":"publisher","first-page":"6207","DOI":"10.1021\/acs.analchem.5c07250","article-title":"A Membrane-Impermeable near-Infrared Probe Enables\nHigh-Fidelity Tracking of Foam Cell Progression","volume":"98","author":"Li","year":"2026","journal-title":"Anal. Chem."},{"key":"2026092909112805100_cit23","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1038\/s41596-024-01122-8","article-title":"Measuring Plasma Membrane\nFluidity Using Confocal Microscopy","volume":"20","author":"Carravilla","year":"2025","journal-title":"Nat. Protoc."},{"key":"2026092909112805100_cit24","doi-asserted-by":"publisher","first-page":"2428","DOI":"10.1021\/acs.analchem.5c06860","article-title":"Anchoring-Detection\nFluorescent Probe for Investigating Microcystin-Lr-Induced\nPlasma Membrane Damage","volume":"98","author":"Wang","year":"2026","journal-title":"Anal. Chem."},{"key":"2026092909112805100_cit25","doi-asserted-by":"publisher","first-page":"114403","DOI":"10.1016\/j.bios.2022.114403","article-title":"Fluorescent Dendrimer-Based\nProbes for Cell Membrane Imaging: Zebrafish Epidermal Labeling-Based\nToxicity Evaluation","volume":"213","author":"Xu","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"2026092909112805100_cit26","doi-asserted-by":"publisher","first-page":"6344","DOI":"10.1039\/D3CS00475A","article-title":"Strategies to Convert\nOrganic Fluorophores into Red\/near-Infrared Emitting Analogues and\nTheir Utilization in Bioimaging Probes","volume":"52","author":"Dai","year":"2023","journal-title":"Chem.\nSoc. Rev."},{"key":"2026092909112805100_cit27","doi-asserted-by":"publisher","first-page":"0010","DOI":"10.1038\/s41551-016-0010","article-title":"Near-Infrared\nFluorophores for Biomedical\nImaging","volume":"1","author":"Hong","year":"2017","journal-title":"Nat. Biomed. Eng."},{"issue":"11","key":"2026092909112805100_cit28","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.308","article-title":"A Onestep Solution to Fix and Stain Cells for Correlative\nLive and Fixed Microscopy","volume":"1","author":"Velle","year":"2021","journal-title":"Curr. Protoc."},{"key":"2026092909112805100_cit29","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0005-2736(90)90240-O","article-title":"Internalization\nof the Lipophilic Fluorescent Probe Trimethylamino-Diphenylhexatriene\nFollows the Endocytosis and Recycling of the Plasma Membrane in Cells","volume":"1030","author":"Illinger","year":"1990","journal-title":"Biophys. Biophys. Acta"},{"key":"2026092909112805100_cit30","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0167-4889(01)00110-0","article-title":"Block Copolymers\nModify the Internalization of Micelle-Incorporated Probes into Neural\nCells","volume":"1539","author":"Maysinger","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"2026092909112805100_cit31","doi-asserted-by":"publisher","first-page":"12098","DOI":"10.1039\/D1CS00645B","article-title":"Small Molecule Based Fluorescent\nChemosensors for Imaging the Microenvironment\nwithin Specific Cellular Regions","volume":"50","author":"Yin","year":"2021","journal-title":"Chem. Soc.\nRev."},{"key":"2026092909112805100_cit32","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1021\/acs.bioconjchem.0c00023","article-title":"Molecular\nTuning of Styryl Dyes Leads to Versatile and Efficient Plasma Membrane\nProbes for Cell and Tissue Imaging","volume":"31","author":"Collot","year":"2020","journal-title":"Bioconjugate\nChem."},{"key":"2026092909112805100_cit33","doi-asserted-by":"publisher","first-page":"7589","DOI":"10.3390\/molecules28227589","article-title":"How to Target Small-Molecule Fluorescent Imaging Probes\nto the Plasma Membrane\u2500the Influence and Qsar Modelling of\nAmphiphilicity, Lipophilicity, and Flip-Flop","volume":"28","author":"Horobin","year":"2023","journal-title":"Molecules"},{"key":"2026092909112805100_cit34","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1093\/procel\/pwac007","article-title":"How Erastin\nAssassinates Cells by Ferroptosis Revealed","volume":"14","author":"Gan","year":"2022","journal-title":"Protein Cell"},{"key":"2026092909112805100_cit35","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1152\/physiol.00029.2023","article-title":"Membrane Dynamics and\nCation Handling in Ferroptosis","volume":"39","author":"Hirata","year":"2024","journal-title":"Physiology"},{"key":"2026092909112805100_cit36","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1038\/s41598-018-19213-4","article-title":"The Ferroptosis Inducer\nErastin Irreversibly Inhibits System Xc\u2013 and Synergizes with\nCisplatin to Increase Cisplatin\u2019s Cytotoxicity in Cancer Cells","volume":"8","author":"Sato","year":"2018","journal-title":"Sci. Rep."},{"key":"2026092909112805100_cit37","doi-asserted-by":"publisher","first-page":"130058","DOI":"10.1016\/j.bmcl.2024.130058","article-title":"Cyclic Vinyl\nSulfones Activate Nrf2 to Protect from Oxidative Stress-Induced Programmed\nNecrosis","volume":"117","author":"Davidovich","year":"2025","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"2026092909112805100_cit38","doi-asserted-by":"publisher","first-page":"554","DOI":"10.4103\/2230-8210.163106","article-title":"Pleiotropic\nEffects of Statins","volume":"19","author":"Kavalipati","year":"2015","journal-title":"Indian J. Endocrinol. Metab."},{"key":"2026092909112805100_cit39","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.cmet.2008.04.001","article-title":"The Cholesterol\nAbsorption Inhibitor Ezetimibe Acts by Blocking the Sterol-Induced\nInternalization of NPC1l1","volume":"7","author":"Ge","year":"2008","journal-title":"Cell Metab."},{"key":"2026092909112805100_cit40","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202405060","article-title":"Ceramide Mediates Cell-to-Cell\nEr Stress Transmission by Modulating Membrane Fluidity","volume":"224","author":"Huo","year":"2025","journal-title":"J. Cell. Biol."},{"key":"2026092909112805100_cit41","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.bbalip.2018.08.006","article-title":"Cytosolic Phospholipase A2 and Lysophospholipid\nAcyltransferases","volume":"1864","author":"Kita","year":"2019","journal-title":"Acta Mol. Cell Biol. Lipids"},{"key":"2026092909112805100_cit42","doi-asserted-by":"publisher","first-page":"132325","DOI":"10.1016\/j.snb.2022.132325","article-title":"High-Fidelity Imaging\nProbe for Lysosomes and Selective Visualization of Cancer Cells and\nTissues","volume":"369","author":"Guan","year":"2022","journal-title":"Sens. Actuators B: Chem."},{"key":"2026092909112805100_cit43","doi-asserted-by":"publisher","first-page":"12095","DOI":"10.1021\/acs.analchem.2c02077","article-title":"Highly Efficient Red\/NIR-Emissive\nFluorescent Probe with Polarity-Sensitive Character for Visualizing\nCellular Lipid Droplets and Determining Their Polarity","volume":"94","author":"Peng","year":"2022","journal-title":"Anal. Chem."},{"key":"2026092909112805100_cit44","doi-asserted-by":"publisher","first-page":"4907","DOI":"10.1021\/ja100351w","article-title":"Switchable Nile Red-Based Probe for Cholesterol and\nLipid Order at the Outer Leaflet of Biomembranes","volume":"132","author":"Kucherak","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"2026092909112805100_cit45","doi-asserted-by":"publisher","first-page":"8887","DOI":"10.1039\/D1CS00083G","article-title":"Fluorescence Imaging\nof Pathophysiological Microenvironments","volume":"50","author":"Wang","year":"2021","journal-title":"Chem.\nSoc. Rev."},{"key":"2026092909112805100_cit46","doi-asserted-by":"publisher","first-page":"113680","DOI":"10.1016\/j.dyepig.2026.113680","article-title":"A Dual-Anchored Fluorescent Probe\nfor Real-Time Monitoring of Cell Membrane Viscosity","volume":"251","author":"Yan","year":"2026","journal-title":"Dyes Pigm."}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.6c05706","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/38\/28608\/68549701\/acs.analchem.6c05706.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/38\/28608\/68549701\/acs.analchem.6c05706.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:36:51Z","timestamp":1790689011000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancham\/article\/98\/38\/28608\/5432328\/Long-Retention-Fluorescent-Probe-for-Plasma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":46,"journal-issue":{"issue":"38","published-online":{"date-parts":[[2026,9,17]]},"published-print":{"date-parts":[[2026,9,29]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.6c05706","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,17]]}}}