{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:30:39Z","timestamp":1787045439514,"version":"build-2736575974"},"reference-count":73,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U24 DK097209"],"award-info":[{"award-number":["U24 DK097209"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Parkinson\u2019s disease (PD) is a neurodegenerative disorder resulting from the loss of dopaminergic neurons of the substantia nigra as well as degeneration of motor and nonmotor basal ganglia circuitries. Typically known for classical motor deficits (tremor, rigidity, bradykinesia), early stages of the disease are associated with a large nonmotor component (depression, anxiety, apathy, etc.). Currently, there are no definitive biomarkers of PD, and the measurement of dopamine metabolites does not allow for detection of prodromal PD nor does it aid in long-term monitoring of disease progression. Given that PD is increasingly recognized as complex and heterogeneous, involving several neurotransmitters and proteins, it is of importance that we advance interdisciplinary studies to further our knowledge of the molecular and cellular pathways that are affected in PD. This approach will possibly yield useful biomarkers for early diagnosis and may assist in the development of disease-modifying therapies. Here, we discuss preanalytical factors associated with metabolomics studies, summarize current mass spectrometric methodologies used to evaluate the metabolic signature of PD, and provide future perspectives of the rapidly developing field of MS in the context of PD.<\/jats:p>","DOI":"10.1021\/acs.analchem.7b04084","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T13:52:59Z","timestamp":1517406779000},"page":"2979-2986","source":"Crossref","is-referenced-by-count":17,"title":["Mass Spectrometric Methodologies for Investigating\nthe Metabolic Signatures of Parkinson\u2019s Disease: Current Progress\nand Future Perspectives"],"prefix":"10.1021","volume":"90","author":[{"given":"Emily\nL.","family":"Gill","sequence":"first","affiliation":[{"name":"University of Florida , , , ,","place":["Gainesville, Florida, United States, 32611"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy P.","family":"Koelmel","sequence":"additional","affiliation":[{"name":"University of Florida , , , ,","place":["Gainesville, Florida, United States, 32611"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1293-5669","authenticated-orcid":true,"given":"Richard A.","family":"Yost","sequence":"additional","affiliation":[{"name":"University of Florida , , , ,","place":["Gainesville, Florida, United States, 32611"]},{"name":"University of Florida , , , ,","place":["Gainesville, Florida, United\nStates, 32610"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Okun","sequence":"additional","affiliation":[{"name":"University of Florida , , , ,","place":["Gainesville, Florida, United\nStates, 32610"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinata","family":"Vedam-Mai","sequence":"additional","affiliation":[{"name":"University of Florida , , , ,","place":["Gainesville, Florida, United\nStates, 32610"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1623-009X","authenticated-orcid":true,"given":"Timothy J.","family":"Garrett","sequence":"additional","affiliation":[{"name":"University of Florida , , , ,","place":["Gainesville, Florida, United\nStates, 32610"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"2026081803201418400_cit1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2741\/S415","volume":"S6","author":"Beitz","year":"2014","journal-title":"Front. 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Neuroimmune Pharmacol."},{"key":"2026081803201418400_cit73","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1152\/jn.01039.2012","volume":"110","author":"Thomas","year":"2013","journal-title":"J. Neurophysiol."}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.7b04084","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/90\/5\/2979\/17732122\/ac7b04084.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/90\/5\/2979\/17732122\/ac7b04084.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:59:45Z","timestamp":1787043585000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancham\/article\/90\/5\/2979\/818466\/Mass-Spectrometric-Methodologies-for-Investigating"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,31]]},"references-count":73,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,1,31]]},"published-print":{"date-parts":[[2018,3,6]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.7b04084","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,31]]}}}