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Multiple-block orthogonal projections to latent structures (OnPLS) is a projection method that simultaneously models multiple data matrices, reducing feature space without relying on a priori biological knowledge. In order to improve the interpretability of OnPLS models, the associated multi-block variable influence on orthogonal projections (MB-VIOP) method is used to identify variables with the highest contribution to the model. This study combined OnPLS and MB-VIOP with interactive visualization methods to interrogate an exemplar multiomics study, using a subset of 22 individuals from an asthma cohort. Joint data structure in six data blocks was assessed: transcriptomics; metabolomics; targeted assays for sphingolipids, oxylipins, and fatty acids; and a clinical block including lung function, immune cell differentials, and cytokines. The model identified seven components, two of which had contributions from all blocks (globally joint structure) and five that had contributions from two to five blocks (locally joint structure). Components 1 and 2 were the most informative, identifying differences between healthy controls and asthmatics and a disease\u2013sex interaction, respectively. The interactions between features selected by MB-VIOP were visualized using chord plots, yielding putative novel insights into asthma disease pathogenesis, the effects of asthma treatment, and biological roles of uncharacterized genes. For example, the gene ATP6 V1G1, which has been implicated in osteoporosis, correlated with metabolites that are dysregulated by inhaled corticoid steroids (ICS), providing insight into the mechanisms underlying bone density loss in asthma patients taking ICS. These results show the potential for OnPLS, combined with MB-VIOP variable selection and interaction visualization techniques, to generate hypotheses from multiomics studies and inform biology.<\/jats:p>","DOI":"10.1021\/acs.analchem.8b03205","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T11:52:00Z","timestamp":1539863520000},"page":"13400-13408","source":"Crossref","is-referenced-by-count":37,"title":["OnPLS-Based Multi-Block Data Integration: A Multivariate\nApproach to Interrogating Biological Interactions in Asthma"],"prefix":"10.1021","volume":"90","author":[{"given":"Stacey N.","family":"Reinke","sequence":"first","affiliation":[{"name":"Karolinska Institute , , ,","place":["Stockholm, Sweden, SE-171 77"]},{"name":"Edith Cowan University , , ,","place":["Perth, Australia, 6027"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Galindo-Prieto","sequence":"additional","affiliation":[{"name":"Umea\u030a University , , ,","place":["Umea\u030a, Sweden, SE-901 87"]},{"name":"Umea\u030a University , , ,","place":["Umea\u030a, Sweden, SE-901 87"]},{"name":"Norwegian University of Science and Technology (NTNU) , , ,","place":["Trondheim, Norway, 7491"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Skotare","sequence":"additional","affiliation":[{"name":"Umea\u030a University , , ,","place":["Umea\u030a, Sweden, SE-901 87"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Broadhurst","sequence":"additional","affiliation":[{"name":"Edith Cowan University , , ,","place":["Perth, Australia, 6027"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akul","family":"Singhania","sequence":"additional","affiliation":[{"name":"Southampton University Hospital , , ,","place":["Southampton, U.K., SO16 6YD"]},{"name":"The Francis Crick Institute , , ,","place":["London, U.K., NW1 1AT"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Janssen Pharmaceutical Companies of Johnson & Johnson , , ,","place":["Spring House, Pennsylvania, United States, 19477"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratko","family":"Djukanovic\u0301","sequence":"additional","affiliation":[{"name":"Southampton University Hospital , , ,","place":["Southampton, U.K., SO16 6YD"]},{"name":"Southampton University Hospital , , ,","place":["Southampton, U.K., SO16 6YD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy S.C.","family":"Hinks","sequence":"additional","affiliation":[{"name":"Southampton University Hospital , , ,","place":["Southampton, U.K., SO16 6YD"]},{"name":"Southampton University Hospital , , ,","place":["Southampton, U.K., SO16 6YD"]},{"name":"University of Oxford , , Level 7, John Radcliffe Hospital, ,","place":["Oxford, U.K., OX3 9DU"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Geladi","sequence":"additional","affiliation":[{"name":"Swedish University of Agricultural Sciences , , ,","place":["Umea\u030a, Sweden, SE 90183"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3799-6094","authenticated-orcid":true,"given":"Johan","family":"Trygg","sequence":"additional","affiliation":[{"name":"Umea\u030a University , , ,","place":["Umea\u030a, Sweden, SE-901 87"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8113-0653","authenticated-orcid":true,"given":"Craig E.","family":"Wheelock","sequence":"additional","affiliation":[{"name":"Karolinska Institute , , ,","place":["Stockholm, Sweden, SE-171 77"]},{"name":"Gunma University , , ,","place":["Maebashi, Japan, 371-8510"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,10,18]]},"reference":[{"key":"2026090211311626300_cit1","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1146\/annurev.genom.2.1.343","article-title":"A new approach\nto decoding life:\nsystems biology","volume":"2","author":"Ideker","year":"2001","journal-title":"Annu. 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Acta"},{"key":"2026090211311626300_cit28","doi-asserted-by":"crossref","unstructured":"Galindo-Prieto, B.\n          \n          Novel\nvariable influence on projection (VIP) methods in OPLS, O2PLS, and\nOnPLS models for single-and multi-block variable selection: VIPOPLS, VIPO2PLS, and MB-VIOP methods. Doctoral Dissertation, Umea\u030a University, Umea\u030a, Sweden, 2017.","DOI":"10.1016\/j.chemolab.2016.11.005"},{"issue":"2","key":"2026090211311626300_cit29","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.jaci.2015.01.014","article-title":"Innate and\nadaptive T cells in asthmatic patients: Relationship to severity and\ndisease mechanisms","volume":"136","author":"Hinks","year":"2015","journal-title":"J. Allergy Clin. 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Biol. Rep."},{"issue":"5","key":"2026090211311626300_cit44","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jgg.2014.04.001","article-title":"Diurnal regulation of lipid metabolism and applications\nof circadian lipidomics","volume":"41","author":"Gooley","year":"2014","journal-title":"J. Genet. Genomics"},{"key":"2026090211311626300_cit45","first-page":"A5210","article-title":"Dynamic Regulation\nOf Circadian Clock Genes In Chronic Airway Disease","volume":"195","author":"Kenfield","year":"2017","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.8b03205","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/90\/22\/13400\/66919123\/acs.analchem.8b03205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/90\/22\/13400\/66919123\/acs.analchem.8b03205.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:31:26Z","timestamp":1788363086000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancham\/article\/90\/22\/13400\/820662\/OnPLS-Based-Multi-Block-Data-Integration-A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,18]]},"references-count":45,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2018,10,18]]},"published-print":{"date-parts":[[2018,11,20]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.8b03205","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,18]]}}}