{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:54:44Z","timestamp":1775091284836,"version":"3.50.1"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"27","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI056312"],"award-info":[{"award-number":["AI056312"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2020,7,14]]},"DOI":"10.1021\/acs.biochem.0c00247","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T07:41:22Z","timestamp":1593243682000},"page":"2484-2493","source":"Crossref","is-referenced-by-count":17,"title":["Altered Drug Transport by <i>Plasmodium falciparum<\/i> Chloroquine Resistance Transporter Isoforms Harboring Mutations Associated with Piperaquine Resistance"],"prefix":"10.1021","volume":"59","author":[{"given":"Bryce","family":"Riegel","sequence":"first","affiliation":[{"name":"Department of Chemistry and Department of Biochemistry and Cellular and Molecular Biology, Georgetown University, Washington, D.C. 20057, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7079-3793","authenticated-orcid":true,"given":"Paul D.","family":"Roepe","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Department of Biochemistry and Cellular and Molecular Biology, Georgetown University, Washington, D.C. 20057, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"ref1\/cit1","unstructured":"World Health\nOrganization (2018) World Malaria\nReport 2018."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606701"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.50"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed4020089"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30391-3"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30392-5"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00487-9"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0900231"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808859"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314981"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.19-0379"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/nature12876"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513137"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/srep17412"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260867"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00487-9"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00835-15"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1403007"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30524-8"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3201\/eid2304.161872"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-017-1680-8"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05652-0"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00366-15"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0539-5"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix334"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30409-1"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evx126"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30415-7"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04104-z"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2018.11.004"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.03.011"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.04.042"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2014.01.004"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(05)00077-8"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1124\/mol.61.1.35"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175667"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/bi901035j"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/bi049137i"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b00749"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00412"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1238-1"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004085"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30543-2"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507142112"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00260-18"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/yea.807"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/bi200922g"},{"key":"ref48\/cit48","volume-title":"Translational Control","author":"Sherman F.","year":"1986"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/bi400557x"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1795-x"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/bi101638n"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2012.08.002"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/bi020195i"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/jp0342982"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/jm400282d"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079059"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(58)90376-0"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01064"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01269-09"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02794-13"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-010-0804-7"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1021\/bi8010658"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.0c00247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T09:44:25Z","timestamp":1682329465000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.0c00247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,26]]},"references-count":62,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2020,7,14]]}},"alternative-id":["10.1021\/acs.biochem.0c00247"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.0c00247","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,26]]}}}