{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:56:34Z","timestamp":1775919394720,"version":"3.50.1"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"45","license":[{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM116921"],"award-info":[{"award-number":["GM116921"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM134881"],"award-info":[{"award-number":["GM134881"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2021,11,16]]},"DOI":"10.1021\/acs.biochem.1c00589","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T20:01:48Z","timestamp":1635883308000},"page":"3362-3373","source":"Crossref","is-referenced-by-count":10,"title":["Protein\u2013Ribofuranosyl Interactions Activate Orotidine 5\u2032-Monophosphate Decarboxylase for Catalysis"],"prefix":"10.1021","volume":"60","author":[{"given":"Judith R.","family":"Cristobal","sequence":"first","affiliation":[{"name":"Department of Chemistry, University at Buffalo, SUNY, Buffalo, New York 14260-3000, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-3014","authenticated-orcid":true,"given":"Tiago A. S.","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Chemistry, ICEx, Federal University of Minas Gerais, Belo Horizonte, MG 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9955-393X","authenticated-orcid":true,"given":"Archie C.","family":"Reyes","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University at Buffalo, SUNY, Buffalo, New York 14260-3000, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0440-2387","authenticated-orcid":true,"given":"John P.","family":"Richard","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University at Buffalo, SUNY, Buffalo, New York 14260-3000, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/161707a0"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470122884.ch4"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/bi301491r"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/ja3058474"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/ja710384t"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1126\/science.7809611"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00059"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b10836"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.030409797"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/bi900623r"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b08897"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/ja505037v"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/bi300585e"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.0c00241"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/bi701664n"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/ja00363a037"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/bi401117y"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/ja055493s"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/bi8001743"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/ja00891a018"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/ja01573a087"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1385\/1-59259-890-0:571","volume-title":"Proteomics Protocols Handbook","author":"Gasteiger E.","year":"2005"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg563"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/bi800939k"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/ja201734z"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/bi301650d"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzw064"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2014.03.001"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00147"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/ja01498a025"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.44.2.98"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b09609"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00591"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b09328"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/ja501103b"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/bi700409b"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c13423"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/bi00663a015"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1007\/bf01686645"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2010.09.005"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b08192"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/bi034374r"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2007.10.020"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b04823"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2941"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.1c00535"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/bi300957f"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2015.12.009"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.1c00589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T10:12:46Z","timestamp":1682503966000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.1c00589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,2]]},"references-count":48,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2021,11,16]]}},"alternative-id":["10.1021\/acs.biochem.1c00589"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.1c00589","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,2]]}}}