{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T06:59:10Z","timestamp":1793343550984,"version":"4.5.0"},"reference-count":90,"publisher":"American Chemical Society (ACS)","issue":"16","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-20-CE45-0002"],"award-info":[{"award-number":["ANR-20-CE45-0002"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012623","name":"Federation of European Biochemical Societies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012623","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2023,8,15]]},"DOI":"10.1021\/acs.biochem.3c00010","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T09:11:24Z","timestamp":1689930684000},"page":"2407-2416","source":"Crossref","is-referenced-by-count":32,"title":["Determination of the Structure and Dynamics of the Fuzzy Coat of an Amyloid Fibril of IAPP Using Cryo-Electron Microscopy"],"prefix":"10.1021","volume":"62","author":[{"given":"Z.","family":"Faidon Brotzakis","sequence":"first","affiliation":[{"name":"Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"L\u00f6hr","sequence":"additional","affiliation":[{"name":"Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9624-4461","authenticated-orcid":true,"given":"Steven","family":"Truong","sequence":"additional","affiliation":[{"name":"Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Hoff","sequence":"additional","affiliation":[{"name":"Department of Structural Biology and Chemistry, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9 CNRS UMR 3528, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7321-0004","authenticated-orcid":true,"given":"Massimiliano","family":"Bonomi","sequence":"additional","affiliation":[{"name":"Department of Structural Biology and Chemistry, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9 CNRS UMR 3528, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3616-1610","authenticated-orcid":true,"given":"Michele","family":"Vendruscolo","sequence":"additional","affiliation":[{"name":"Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,7,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251652"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.10.005"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1981.tb02483.x"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1982.tb04625.x"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1017\/S0033583504003920"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.77"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2829-0"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1126"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3991(81)90059-0"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2018.10.006"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2016.12.004"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c00123"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/ct300112v"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1063\/1.4793625"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1063\/1.4792208"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003406"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1063\/1.4937786"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1501177"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2015.05.024"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1704803114"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3390\/computation6010015"},{"key":"ref22\/cit22","first-page":"219","volume-title":"Methods in Molecular Biology","volume":"2112","author":"Bottaro S.","year":"2020"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2012423118"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1140\/epjb\/s10051-021-00154-3"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/jp5021824"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat4010"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb5924"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s43588-020-00003-w"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1063\/1.4981211"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M114.040824"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.9b00338"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56518"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.9b01181"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc3786"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2018.02.028"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1101\/2023.01.19.524720"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1805125115"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1900441116"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.1c00585"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2104093118"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC00244A"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2205412119"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1063\/1.475562"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1063\/1.1562614"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.94.018104"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1063\/1.1738640"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1063\/1.5119252"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9991(77)90121-8"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.52.2893"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.86.2050"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1063\/1.1410978"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202427399"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physchem-040215-112229"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1002\/adts.202000237"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0506-8"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00846"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600917113"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.7b00182"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1063\/1.5025487"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.8b00827"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/srep31232"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.654333"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15046"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02597-0"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.9b03623"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010145"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01122"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.757425"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0435-3"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-021-00646-x"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0442-4"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.611285"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1212100110"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/jp054359r"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910007493"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798319016577"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1038\/nature23002"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2011.03.051"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1063\/1.445869"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.108.137125"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpc.2013.09.018"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.100.020603"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1021\/ct3002464"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19990115)38:1\/2<236::AID-ANIE236>3.0.CO;2-M"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20084"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1038\/nature03199"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2014.09.026"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.12.032"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1101\/2021.11.10.468009"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.3c00010","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.3c00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T04:14:17Z","timestamp":1692072857000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.3c00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,21]]},"references-count":90,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2023,8,15]]}},"alternative-id":["10.1021\/acs.biochem.3c00010"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.3c00010","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.05.29.493873","asserted-by":"object"}]},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,21]]}}}