{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:38:19Z","timestamp":1784561899211,"version":"3.55.0"},"reference-count":75,"publisher":"American Chemical Society (ACS)","issue":"14","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["CE200100012"],"award-info":[{"award-number":["CE200100012"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["CE200100029"],"award-info":[{"award-number":["CE200100029"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["LP160101552"],"award-info":[{"award-number":["LP160101552"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2023,7,18]]},"DOI":"10.1021\/acs.biochem.3c00038","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T16:07:30Z","timestamp":1687882050000},"page":"2202-2215","source":"Crossref","is-referenced-by-count":4,"title":["Complex Inhibitory Mechanism of Glycomimetics with Heparanase"],"prefix":"10.1021","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3387-7744","authenticated-orcid":true,"given":"Cassidy","family":"Whitefield","sequence":"first","affiliation":[{"name":"Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 2601, Australia"},{"name":"Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Australian National University, Canberra, Australian Capital Territory 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen","family":"Vo","sequence":"additional","affiliation":[{"name":"Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett D.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 2601, Australia"},{"name":"Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Australian National University, Canberra, Australian Capital Territory 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caryn","family":"Hepburn","sequence":"additional","affiliation":[{"name":"Waters Australia Pty Ltd, 38-46 South Street, Rydalmere, New South Wales 2116, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9153-2699","authenticated-orcid":true,"given":"F. Hafna","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Onagi","sequence":"additional","affiliation":[{"name":"Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G.","family":"Banwell","sequence":"additional","affiliation":[{"name":"Institute for Advanced and Applied Chemical Synthesis, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keats","family":"Nelms","sequence":"additional","affiliation":[{"name":"Beta Therapeutics Pty. Ltd. Level 6, 121 Marcus Clarke Street, Canberra, Australian Capital Territory 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7691-6432","authenticated-orcid":true,"given":"Lara R.","family":"Malins","sequence":"additional","affiliation":[{"name":"Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 2601, Australia"},{"name":"Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Australian National University, Canberra, Australian Capital Territory 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6150-3822","authenticated-orcid":true,"given":"Colin J.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 2601, Australia"},{"name":"Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Australian National University, Canberra, Australian Capital Territory 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004952"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.60.070191.002303"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/35008000"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M510722200"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/453801"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2013.10.004"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.03.001"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1242\/dev.098178"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90512-W"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.03.014"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.274.34.23916"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-006-0722-x"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/10518"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/10525"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1006\/BBRC.1999.0962"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.274.34.24153"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1171442"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2020.575047"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041280223"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0895fje"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/srep46229"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.6.3830"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13713"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.1.11.833"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1611380113"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.03.014"},{"key":"ref27\/cit27","first-page":"3433","volume":"59","author":"Parish C. R.","year":"1999","journal-title":"Cancer Res."},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/jm201708h"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414217200"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021106"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/J.BMCL.2005.09.070"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/J.BMCL.2005.03.014"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00908"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037938"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2203167119"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2718"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.11.038"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.48.357"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/J.EJMECH.2016.05.052"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2016.08.006"},{"key":"ref41\/cit41","unstructured":"Davar, D. Phase IIA Basket Study of Pixatimod (PG545) in Combination With Nivolumab in PD-1 Relapsed\/Refractory Metastatic Melanoma and NSCLC and Pixatimod (PG545) in Combination With Nivolumab and Low-Dose Cyclophosphamide in MSS Metastatic Colorectal Carcinoma (MCRC);  Clinical Trial Registration NCT05061017; clinicaltrials.gov, 2022. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05061017 (accessed 2022-11-28)."},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.182865"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.03.005"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp524"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054459"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-010-1252-8"},{"key":"ref47\/cit47","first-page":"1454","volume":"16","author":"Kongtawelert P.","year":"1989","journal-title":"J. Rheumatol."},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.164"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910400414"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1039\/D1CB00239B"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202100527"},{"key":"ref63\/cit63","first-page":"349","volume-title":"Synthetic Biology, Part B","volume":"498","author":"Gibson D. G.","year":"2011"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2009.09.007"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07601.x"},{"key":"ref65\/cit65","first-page":"95","volume-title":"Comprehensive Enzyme Kinetics","author":"Leskovac V.","year":"2003"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1107\/S1600577518003120"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798317017235"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910045749"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1126\/science.1218231"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444912001308"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904019158"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909042073"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889810015608"},{"key":"ref74\/cit74","unstructured":"DeLano, W. L. The PyMOL Molecular Graphics System. DeLano Scientific, 2002."},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm351"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3136"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.fob.2013.07.007"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cww003"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.pisc.2013.12.001"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1007\/s12154-008-0011-5"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414546200"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/bm301007r"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2020.1862239"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.04.026"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202104222"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.3c00038","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.3c00038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T08:12:40Z","timestamp":1689667960000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.3c00038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,27]]},"references-count":75,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2023,7,18]]}},"alternative-id":["10.1021\/acs.biochem.3c00038"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.3c00038","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,27]]}}}