{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:46:59Z","timestamp":1786999619477,"version":"build-2736575974"},"reference-count":73,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT190298"],"award-info":[{"award-number":["PJT190298"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2025,1,21]]},"DOI":"10.1021\/acs.biochem.4c00585","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T23:51:41Z","timestamp":1736293901000},"page":"301-311","source":"Crossref","is-referenced-by-count":2,"title":["The Janus Effect: The Biochemical Logic of Antibiotic Resistance"],"prefix":"10.1021","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9129-7131","authenticated-orcid":true,"given":"Gerard D.","family":"Wright","sequence":"first","affiliation":[{"name":"David Braley Centre for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","DOI":"10.1128\/9781555819316","volume-title":"Antibiotics: Challenges, Mechanisms, Opportunities","author":"Walsh C. T.","year":"2016"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-023-00029-5"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03218-w"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1128\/ecosalplus.ESP-0027-2020"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abo7793"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2016.04.006"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/bi8002023"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01137"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184671"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.06.044"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00638-0"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physchem-042018-052340"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00484"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000414"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80444-4"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060713-035600"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1128\/ecosalplus.esp-0001-2018"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01213"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3213"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2004.tb09639.x"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00064-16"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/679109"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c01051"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2023.102647"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2023.10.006"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01076-18"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1042\/bj0880452"},{"key":"ref29\/cit29","first-page":"853","volume":"266","author":"Christensen H.","year":"1990","journal-title":"Biochem. J."},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20983"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.9.2276-2285.2000"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01601"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0048-6"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.48.100194.002021"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2023-0070"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01119-y"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2020.08.004"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/bi201790u"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22016-3"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03219-w"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/bi035667n"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.1.1"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03743-14"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02705-20"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-023-01483-3"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2017.03.007"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80274-3"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02680-0"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.11.2690"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402358111"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11343"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409573200"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2015.05.017"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/41.6.584"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-090816-093813"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fux004"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601208113"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg222"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2014.107"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1039\/D2MD00459C"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/bi973113c"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-020-00715-0"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-023-01525-w"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1501775112"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.06.034"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.06.019"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198807213190307"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(96)90079-4"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1128\/jb.174.8.2582-2591.1992"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1021\/bi00107a007"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1021\/bi00008a008"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/ja035901x"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01172-17"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.4c00585","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.4c00585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T04:10:22Z","timestamp":1737432622000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.4c00585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":73,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1,21]]}},"alternative-id":["10.1021\/acs.biochem.4c00585"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.4c00585","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]}}}