{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:58:56Z","timestamp":1782179936106,"version":"3.54.5"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1154434"],"award-info":[{"award-number":["1154434"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1155302"],"award-info":[{"award-number":["1155302"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1159006"],"award-info":[{"award-number":["1159006"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2025694"],"award-info":[{"award-number":["2025694"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2026300"],"award-info":[{"award-number":["2026300"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2008341"],"award-info":[{"award-number":["GNT2008341"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT200100218"],"award-info":[{"award-number":["FT200100218"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2025,6,17]]},"DOI":"10.1021\/acs.biochem.4c00855","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T20:13:56Z","timestamp":1748376836000},"page":"2556-2576","source":"Crossref","is-referenced-by-count":3,"title":["Unique Biased Agonism Profile of \u03b2CGRP on CGRP Family Receptors"],"prefix":"10.1021","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8266-8604","authenticated-orcid":true,"given":"Grace","family":"Mennen","sequence":"first","affiliation":[{"name":"Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences","place":["Parkville, Australia"]},{"name":"Monash University","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi","family":"Ying","sequence":"additional","affiliation":[{"name":"Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences","place":["Parkville, Australia"]},{"name":"Monash University","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5519-4832","authenticated-orcid":true,"given":"Madeleine M.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences","place":["Parkville, Australia"]},{"name":"Monash University","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Abdur Razzak","sequence":"additional","affiliation":[{"name":"Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences","place":["Parkville, Australia"]},{"name":"Monash University","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4019-5538","authenticated-orcid":true,"given":"Laura","family":"Humphrys","sequence":"additional","affiliation":[{"name":"Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences","place":["Parkville, Australia"]},{"name":"Monash University","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7799-3683","authenticated-orcid":true,"given":"Tracy M.","family":"Josephs","sequence":"additional","affiliation":[{"name":"Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences","place":["Parkville, Australia"]},{"name":"Monash University","place":["Parkville, Australia"]},{"name":"ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences","place":["Parkville, Australia"]},{"name":"Monash University","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8902-2473","authenticated-orcid":true,"given":"Patrick M.","family":"Sexton","sequence":"additional","affiliation":[{"name":"Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences","place":["Parkville, Australia"]},{"name":"Monash University","place":["Parkville, Australia"]},{"name":"ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences","place":["Parkville, Australia"]},{"name":"Monash University","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4563-1642","authenticated-orcid":true,"given":"Denise","family":"Wootten","sequence":"additional","affiliation":[{"name":"Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences","place":["Parkville, Australia"]},{"name":"Monash University","place":["Parkville, Australia"]},{"name":"ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences","place":["Parkville, Australia"]},{"name":"Monash University","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0185-0595","authenticated-orcid":true,"given":"Peishen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences","place":["Parkville, Australia"]},{"name":"Monash University","place":["Parkville, Australia"]},{"name":"ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences","place":["Parkville, Australia"]},{"name":"Monash University","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/30666"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705472"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14075"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(88)90018-8"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(85)90050-3"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(85)90456-X"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90696-7"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2019.1618830"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305332200"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.9b00083"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.751362"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.840763"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.01.030"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.013854"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.173948"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02293-w"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104785"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116235"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/298240a0"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(85)80820-6"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(86)81338-2"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjac190.0217"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1111\/head.14768"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e03223"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(02)00221-7"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.8.4359"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02202.x"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-020-0535-8"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.599712"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12178"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.001975"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609695200"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1124\/molpharm.123.000865"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.121.000567"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/cn200111m"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1706656114"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-6997(24)01478-9"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107323200"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1983.0093"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15628"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.021"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004534200"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.03.037"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-14"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031195"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth742"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1134"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/0898-6568(95)02056-X"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15605"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.4c00855","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.4c00855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T08:11:25Z","timestamp":1750147885000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.4c00855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,27]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,6,17]]}},"alternative-id":["10.1021\/acs.biochem.4c00855"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.4c00855","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,27]]}}}