{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:41:05Z","timestamp":1789713665412,"version":"4.0.1"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"19","funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2014ZX09101044-001"],"award-info":[{"award-number":["2014ZX09101044-001"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30931872"],"award-info":[{"award-number":["30931872"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102365"],"award-info":[{"award-number":["81102365"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2015,5,19]]},"DOI":"10.1021\/acs.biochem.5b00067","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T12:36:26Z","timestamp":1430224586000},"page":"2988-2996","source":"Crossref","is-referenced-by-count":13,"title":["The Functional Property Changes of Muscular Na<sub>v<\/sub>1.4 and Cardiac Na<sub>v<\/sub>1.5 Induced by Scorpion Toxin BmK AGP-SYPU1 Mutants Y42F and Y5F"],"prefix":"10.1021","volume":"54","author":[{"given":"Xiangxue","family":"Meng","sequence":"first","affiliation":[{"name":"School of Life Sciences & Biopharmaceutical Science, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, PR China"},{"name":"Benxi\rMedicine Institute, Shenyang Pharmaceutical University, Shiqiaozi, 177005 Benxi, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Life Sciences & Biopharmaceutical Science, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Life Sciences & Biopharmaceutical Science, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences & Biopharmaceutical Science, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Life Sciences & Biopharmaceutical Science, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Life Sciences & Biopharmaceutical Science, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Sciences & Biopharmaceutical Science, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbo","family":"Song","sequence":"additional","affiliation":[{"name":"School of Life Sciences & Biopharmaceutical Science, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghai","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Sciences & Biopharmaceutical Science, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, PR China"},{"name":"School\rof Medical Devices, Shenyang Pharmaceutical University, 103 Wenhua\rRoad, 110016 Shenyang, PR China"},{"name":"Benxi\rMedicine Institute, Shenyang Pharmaceutical University, Shiqiaozi, 177005 Benxi, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,5,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.toxicon.2006.09.022","volume":"49","author":"Catterall W. A.","year":"2007","journal-title":"Toxicon"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.toxicon.2006.09.023","volume":"49","author":"Bosmans F.","year":"2007","journal-title":"Toxicon"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuron.2007.07.016","volume":"55","author":"Woolf C. J.","year":"2007","journal-title":"Neuron"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev-pharmtox-011112-140232","volume":"54","author":"Catterall W. A.","year":"2014","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0092-8674(95)90359-3","volume":"80","author":"Wang Q.","year":"1995","journal-title":"Cell"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrcardio.2009.44","volume":"6","author":"Ruan Y.","year":"2009","journal-title":"Nature Rev. Cardiol."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1161\/CIRCULATIONAHA.107.707877","volume":"116","author":"Ruan Y.","year":"2007","journal-title":"Circulation"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1172\/JCI25505","volume":"115","author":"George A. L.","year":"2005","journal-title":"J. Clin. Invest."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0960-8966(02)00007-X","volume":"12","author":"Cannon S. C.","year":"2002","journal-title":"Neuromuscular Disord."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1152\/physrev.1999.79.4.1317","volume":"79","author":"Lehmann-Horn F.","year":"1999","journal-title":"Physiol. Rev."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S1471-4892(01)00050-9","volume":"1","author":"Jurkat-Rott K.","year":"2001","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/32675","volume":"392","author":"Chen Q.","year":"1998","journal-title":"Nature"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/humu.21066","volume":"30","author":"Hedley P. L.","year":"2009","journal-title":"Human Mutat."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1016\/j.hrthm.2012.08.027","volume":"9","author":"Marquez M. F.","year":"2012","journal-title":"Heart Rhythm"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1161\/01.CIR.0000160853.19867.61","volume":"111","author":"Royer A.","year":"2005","journal-title":"Circulation"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"31679","DOI":"10.1074\/jbc.M402048200","volume":"279","author":"Karbat I.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1006\/jmbi.1999.3036","volume":"292","author":"He X. L.","year":"1999","journal-title":"J. Mol. Biol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bbrc.2010.02.179","volume":"394","author":"Ma R.","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1034\/j.1399-3011.2002.21021.x","volume":"60","author":"Sun Y. M.","year":"2002","journal-title":"J. Pept. Res."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"24125","DOI":"10.1074\/jbc.M211931200","volume":"278","author":"Sun Y. M.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/bmc.1519","volume":"25","author":"Wang Y.","year":"2010","journal-title":"Biomed. Chromatogr."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10930-014-9547-0","volume":"33","author":"Deng L.","year":"2014","journal-title":"Protein J."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1124\/jpet.108.138230","volume":"326","author":"Cao Z.","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1111\/j.1476-5381.2010.00976.x","volume":"161","author":"Kahlig K. M.","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/nt.2620010510","volume":"1","author":"Kopeyan C.","year":"1993","journal-title":"Natural Toxins"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1085\/jgp.117.6.505","volume":"117","author":"Chen H.","year":"2001","journal-title":"J. Gen. Physiol."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1046\/j.1471-4159.1995.65031358.x","volume":"65","author":"Thomsen W.","year":"1995","journal-title":"J. Neurochem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1111\/j.1476-5381.2009.00471.x","volume":"158","author":"Zhu M. M.","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1021\/bi00217a007","volume":"30","author":"Loret E. P.","year":"1991","journal-title":"Biochemistry"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1097\/00001756-199911080-00019","volume":"10","author":"Jia L. Y.","year":"1999","journal-title":"Neuroreport"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1021\/cb400012k","volume":"8","author":"Durek T.","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbrc.2014.08.051","volume":"452","author":"Liu X.","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neulet.2005.08.003","volume":"390","author":"Chen J.","year":"2005","journal-title":"Neurosci. Lett."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.toxicon.2012.03.022","volume":"60","author":"Gurevitz M.","year":"2012","journal-title":"Toxicon"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"20684","DOI":"10.1074\/jbc.M109.021303","volume":"284","author":"Kahn R.","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1432-1033.1989.tb14735.x","volume":"181","author":"Kharrat R.","year":"1989","journal-title":"Eur. J. Biochem."}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.5b00067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T12:43:34Z","timestamp":1681389814000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.5b00067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,4]]},"references-count":36,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2015,5,19]]}},"alternative-id":["10.1021\/acs.biochem.5b00067"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.5b00067","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,4]]}}}