{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:43:32Z","timestamp":1790772212248,"version":"4.1.0"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"39","funder":[{"DOI":"10.13039\/501100001825","name":"Styrelsen for Forskning og Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41-GM104601"],"award-info":[{"award-number":["P41-GM104601"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-GM101048"],"award-info":[{"award-number":["R01-GM101048"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54-GM087519"],"award-info":[{"award-number":["U54-GM087519"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["TG-MCA06N060"],"award-info":[{"award-number":["TG-MCA06N060"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2015,10,6]]},"DOI":"10.1021\/acs.biochem.5b00417","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T10:08:12Z","timestamp":1441706892000},"page":"6123-6131","source":"Crossref","is-referenced-by-count":34,"title":["Membrane Interaction of the Factor VIIIa Discoidin Domains in Atomistic Detail"],"prefix":"10.1021","volume":"54","author":[{"given":"Jesper J.","family":"Madsen","sequence":"first","affiliation":[{"name":"Global\rResearch, Novo Nordisk A\/S, DK-2760 M\u00e5l\u00f8v, Denmark"},{"name":"Department\rof Chemistry, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. Zenmei","family":"Ohkubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther H.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan H.","family":"Faber","sequence":"additional","affiliation":[{"name":"Global\rResearch, Novo Nordisk A\/S, DK-2760 M\u00e5l\u00f8v, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Tajkhorshid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole H.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Global\rResearch, Novo Nordisk A\/S, DK-2760 M\u00e5l\u00f8v, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,9,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/202498a0"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1126\/science.145.3638.1310"},{"key":"ref3\/cit3","volume-title":"Hemostasis and Thrombosis: Basic Principles and Clinical Practice","author":"Marder V. J.","year":"2012","edition":"6"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1016\/S0021-9258(19)69627-4","volume":"256","author":"Van Dieijen G.","year":"1981","journal-title":"J. Biol. Chem."},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2328"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.106906"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/46601"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-01-068957"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20140121"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-531822"},{"key":"ref11\/cit11","volume-title":"Lectins","author":"Sharon N.","year":"2003","edition":"2"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-434027"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/46594"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104732200"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-408245"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1182\/blood.V75.10.1999.1999","volume":"75","author":"Foster P. A.","year":"1990","journal-title":"Blood"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-301663"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-197707"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2011.03.014"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.473116"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.497289"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2008.03.001"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.080168"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20130025"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.11.072"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02810.x"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/bip.22199"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3791\/51254"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-06-0481"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-02-0180"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2012.03.015"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/jp4089113"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/prot.20660"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21224"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4157(00)00016-2"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(04)74225-3"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1063\/1.467468"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1063\/1.470648"},{"key":"ref40\/cit40","volume-title":"Computer simulation of liquids","author":"Allen M. P.","year":"1989"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1063\/1.470117"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20289"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/jp973084f"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20065"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/ct300400x"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1063\/1.445869"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9991(77)90098-5"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1063\/1.1809588"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-511733"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/380041a0"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.21.9796"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20101797"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btk023"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-109918"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2012.11.2405"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2006.07.002"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"8815","DOI":"10.1016\/S0021-9258(18)52947-1","volume":"268","author":"Bardelle C.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(77)80200-3"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2012-0298"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.1998.0214"},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1055\/s-0037-1613761","volume":"83","author":"Gale A. J.","year":"2000","journal-title":"Thromb. Haemost."},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1182\/blood.V96.3.979","volume":"96","author":"Liu M. L.","year":"2000","journal-title":"Blood"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-09-0572"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-391680"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1161\/hq0302.105359"},{"key":"ref68\/cit68","unstructured":"Faber, J. H., Appa, R. S., Stennicke, H., and Kjalke, M. (2013) Contribution of C2 domain epitopes in FVIII cellular uptake assessed by epitope mapping of the anti-C2 antibodies ESH4 and ESH8 by hydrogen-deuterium exchange mass spectrometry. FASEB Summer Research Conference on Proteases in Hemostasis & Vascular Biology, June 2\u20137, Nassau, Bahamas."},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1038\/nsb971"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2007.10.021"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1021\/jp2048579"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.5b00417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T07:56:59Z","timestamp":1680854219000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.5b00417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,21]]},"references-count":70,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2015,10,6]]}},"alternative-id":["10.1021\/acs.biochem.5b00417"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.5b00417","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,21]]}}}