{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:16:13Z","timestamp":1787066173753,"version":"build-2736575974"},"reference-count":79,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100006686","name":"University of Miami","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019337","name":"Miami Clinical and Translational Science Institute, University of Miami","doi-asserted-by":"publisher","award":["UL1TR002736"],"award-info":[{"award-number":["UL1TR002736"]}],"id":[{"id":"10.13039\/100019337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2025,3,4]]},"DOI":"10.1021\/acs.biochem.5c00012","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:32:11Z","timestamp":1740173531000},"page":"1121-1135","source":"Crossref","is-referenced-by-count":3,"title":["Multiple Copper Ions Bind to and Promote the Oligomerization of Huntingtin Protein with Nonpathological Repeat Expansions"],"prefix":"10.1021","volume":"64","author":[{"given":"Deepa","family":"Neupane","sequence":"first","affiliation":[{"name":"Department of Chemistry","place":["Coral Gables, United States"]},{"name":"University of Miami","place":["Coral Gables, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4233-0203","authenticated-orcid":true,"given":"Miguel","family":"Santos-Fernandez","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry","place":["Miami, United States"]},{"name":"Florida International University","place":["Miami, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1283-4390","authenticated-orcid":true,"given":"Francisco","family":"Fernandez-Lima","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry","place":["Miami, United States"]},{"name":"Florida International University","place":["Miami, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8316-9199","authenticated-orcid":true,"given":"Katlyn K.","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Coral Gables, United States"]},{"name":"University of Miami","place":["Coral Gables, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1159\/000524732"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25717"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.4.1953"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.2945"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-14169-y"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170518094404"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3390\/ph11040109"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031069"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239259"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2021.126779"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000334"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308535110"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1274-7"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1300405"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfae092"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2005.10.001"},{"key":"ref17\/cit17","volume-title":"Huntington\u2019s Disease","author":"Zuccato C.","year":"2014"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.02.003"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1420103111"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1870-13.2014"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18065"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16318-1"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.12.013"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401886"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2004.01.008"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09923-2"},{"issue":"5","key":"ref27\/cit27","first-page":"376","volume":"7","author":"Chen X.","year":"2012","journal-title":"Neural Regener. Res."},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2022.910427"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24081583"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00138A"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0379-2"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115721"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00594-4"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi147"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1385\/MN:28:3:259"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2003.07.001"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.199448"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.65.1.1-43.2001"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12748-y"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2016.02.007"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707412104"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/bmb.20644"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6118"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101363"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.712555"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.07.030"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac345"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2009.10.002"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112262"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)92201-2"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(199907)14:4<545::AID-MDS1001>3.0.CO;2-U"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22261"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2010.06.010"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1530\/REP-15-0596"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166928"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.134.5.3371"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2006.12.007"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/ja0390350"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.2c00057"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1818274116"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.120163"},{"key":"ref62\/ref62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01229-y"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020195"},{"key":"ref64\/cit64","doi-asserted-by":"crossref","DOI":"10.1002\/9780470191712","volume-title":"Bioinorganic Chemistry: A Short Course","author":"Roat-Malone R. M.","year":"2007"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1039\/B817061D"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2009.08.002"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1038\/nature25502"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1039\/c3dt50540e"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107077200"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1086112"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11081470"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-018-0277-3"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.03.013"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7431.1"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.3390\/atmos11101098"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-020-00189-z"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000036375"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X22666231103085859"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.5c00012","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.5c00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T04:11:49Z","timestamp":1741061509000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.5c00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,21]]},"references-count":79,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,3,4]]}},"alternative-id":["10.1021\/acs.biochem.5c00012"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.5c00012","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,21]]}}}