{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:47:59Z","timestamp":1786999679463,"version":"build-2736575974"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"15","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2022\/003222"],"award-info":[{"award-number":["CRG\/2022\/003222"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008984","name":"Indian Institute of Technology Kharagpur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005808","name":"Indian Institute of Technology Bombay","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005808","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2025,8,5]]},"DOI":"10.1021\/acs.biochem.5c00158","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T14:51:34Z","timestamp":1752072694000},"page":"3203-3218","source":"Crossref","is-referenced-by-count":1,"title":["Enhanced G-Quadruplex Stability and Anticancer Activity of\n                    <i>N<\/i>\n                    <sup>2<\/sup>\n                    -Aryl Deoxyguanosine-Modified T40214 Oligonucleotides Targeting STAT3 in Prostate Cancer"],"prefix":"10.1021","volume":"64","author":[{"given":"Nishant Kumar","family":"Choudhary","sequence":"first","affiliation":[{"name":"Department of Chemistry","place":["Kharagpur, India"]},{"name":"Indian Institute of Technology Kharagpur","place":["Kharagpur, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swrajit Nath","family":"Sharma","sequence":"additional","affiliation":[{"name":"School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gourav","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Kharagpur, India"]},{"name":"Indian Institute of Technology Kharagpur","place":["Kharagpur, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atanu","family":"Ghosh","sequence":"additional","affiliation":[{"name":"School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharam Shivappa","family":"Bagale","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Mumbai, India"]},{"name":"Indian Institute of Technology Bombay","place":["Mumbai, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8884-1194","authenticated-orcid":true,"given":"Surajit","family":"Sinha","sequence":"additional","affiliation":[{"name":"School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-3022","authenticated-orcid":true,"given":"Kiran R.","family":"Gore","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Kharagpur, India"]},{"name":"Indian Institute of Technology Kharagpur","place":["Kharagpur, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81959-5"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1089\/104454903770946665"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81443-9"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304531200"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/28101"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5332.1630"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-4041"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0534764100"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.31.1.129"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11111681"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-3-319-42949-6_5","volume-title":"STAT Inhibitors in Cancer","author":"Bharadwaj U.","year":"2016"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2005.00053.x"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1089\/104454903770946665"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20807"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-007-9147-6"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.2174\/1381612054546761"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr539"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119524"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1039\/C8OB03100B"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa118"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/bc070062f"},{"key":"ref22\/cit22","first-page":"82","volume":"40","author":"DeLano W. L.","year":"2002","journal-title":"CCP4 Newsl. Protein Crystallogr."},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2017.01.006"},{"key":"ref24\/cit24","unstructured":"Frisch, M. J.; Trucks, G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Scalmani, G.; Barone, V.; Petersson, G. A.; Nakatsuji, H.; Li, X.; Caricato, M.; Marenich, A. V.; Bloino, J.; Janesko, B. G.; Gomperts, R.; Mennucci, B.; Hratchian, H. P.; Ortiz, J. V.; Izmaylov, A. F.; Sonnenberg, J. L.; Williams-Young, D.; Ding, F.; Lipparini, F.; Egidi, F.; Goings, J.; Peng, B.; Petrone, A.; Henderson, T.; Ranasinghe, D.; Zakrzewski, V. G.; Gao, J.; Rega, N.; Zheng, G.; Liang, W.; Hada, M.; Ehara, M.; Toyota, K.; Fukuda, R.; Hasegawa, J.; Ishida, M.; Nakajima, T.; Honda, Y.; Kitao, O.; Nakai, H.; Vreven, T.; Throssell, K.; Montgomery, J. A.; Peralta, J. E.; Ogliaro, F.; Bearpark, M. J.; Heyd, J. J.; Brothers, E. N.; Kudin, K. N.; Staroverov, V. N.; Keith, T. A.; Kobayashi, R.; Normand, J.; Raghavachari, K.; Rendell, A. P.; Burant, J. C.; Iyengar, S. S.; Tomasi, J.; Cossi, M.; Millam, J. M.; Klene, M.; Adamo, C.; Cammi, R.; Ochterski, J. W.; Martin, R. L.; Morokuma, K.; Farkas, O.; Foresman, J. B.; Fox, D. J.\n                      Gaussian 16\n                      , Revision B.01; Gaussian, Inc.: Wallingford CT, 2016."},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1103\/physrevb.37.785"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1063\/1.462066"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1063\/1.474659"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr288"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1039\/c0cp00111b"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/ct600329w"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.6b00186"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1063\/1.445869"},{"key":"ref33\/cit33","unstructured":"Case, D. A.; Belfon, K.; Ben-Shalom, I. Y.; Brozell, S. R.; Cerutti, D. S.; Cheatham, I. I. I. T. E.; Cruzeiro, V. W. D.; Darden, T. A.; Duke, R. E.; Giambasu, G.; Gilson, M. K.; Gohlke, H.; Goetz, A. W.; Harris, R.; Izadi, S.; Izmailov, S. A.; Kasavajhala, K.; Kovalenko, A.; Krasny, R.; Kurtzman, T.; Lee, T. S.; LeGrand, S.; Li, P.; Lin, C.; Liu, J.; Luchko, T.; Luo, R.; Man, V.; Merz, K. M.; Miao, Y.; Mikhailovskii, O.; Monard, G.; Nguyen, H.; Onufriev, A.; Pan, F.; Pantano, S.; Qi, R.; Roe, D. R.; Roitberg, A.; Sagui, C.; Schott-Verdugo, S.; Shen, J.; Simmerling, C. L.; Skrynnikov, N. R.; Smith, J.; Swails, J.; Walker, R. C.; Wang, J.; Wilson, L.; Wolf, R. M.; Wu, X.; Xiong, Y.; Xue, Y.; York, D. M.; Kollman, P. A.\n                      AMBER\n                      ; University of California: San Francisco, 2020."},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00255"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/ct200909j"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/ct400341p"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2019.05.019"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg520"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh381"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0312-x"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1063\/1.448118"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1063\/1.470117"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9991(77)90098-5"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5b02341"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202319828"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gni134"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.4c00407"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.2174\/156802608786141133"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1225"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401231"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.5.1545"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.170"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-6-24"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-2506-2"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205260"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208719"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0045(19971001)33:2<123::AID-PROS6>3.0.CO;2-L"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(01)62835-0"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/ci200625q"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.5c00158","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.5c00158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T08:10:24Z","timestamp":1754381424000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.5c00158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,9]]},"references-count":60,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2025,8,5]]}},"alternative-id":["10.1021\/acs.biochem.5c00158"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.5c00158","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,9]]}}}