{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:32:13Z","timestamp":1792794733625,"version":"4.5.0"},"reference-count":76,"publisher":"American Chemical Society (ACS)","issue":"13","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2025,7,1]]},"DOI":"10.1021\/acs.biochem.5c00234","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T11:44:30Z","timestamp":1750333470000},"page":"2712-2726","source":"Crossref","is-referenced-by-count":11,"title":["A Tight-Knit Family: The Medium-Chain Dehydrogenase\/Reductases of Monoterpene Indole Alkaloid Biosynthesis"],"prefix":"10.1021","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7060-5038","authenticated-orcid":true,"given":"Samuel C.","family":"Carr","sequence":"first","affiliation":[{"name":"Department of Natural Product Biosynthesis","place":["Jena, Germany"]},{"name":"Max Planck Institute for Chemical Ecology","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0356-6213","authenticated-orcid":true,"given":"Sarah E.","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Department of Natural Product Biosynthesis","place":["Jena, Germany"]},{"name":"Max Planck Institute for Chemical Ecology","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1039\/b512615k"},{"key":"ref2\/cit2","first-page":"3798","volume":"36","author":"Himes R. H.","year":"1976","journal-title":"Cancer Res."},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(91)90081-V"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nature03566"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-144"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.9b00141"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b00360"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2011.08.022"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nek011"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1185\/030079904125003080"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1159\/000052069"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1159\/000052068"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2022.2131330"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(76)80049-X"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/226761a0"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1080\/00952990.2017.1320802"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.08.034"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/prot.25891"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2229-9-26"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307987100"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8587-z"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8588-y"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8593-1"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/bi00476a001"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560040611"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/bi5006442"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b00446"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202210934"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1879"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-07100-w"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC03612F"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.06.223"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4606"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/srep08258"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12116"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2015.02.006"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00154-x"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1719979115"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat4100"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1501821112"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1111\/nph.19162"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c00206"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202418306"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1007\/s00425-023-04287-w"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c13644"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202307995"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-05574-8"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1007\/s00425-015-2446-6"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-44797-z"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04950-4"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b05999"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)03045-9"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/nature11692"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-023-01327-0"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/s41477-022-01291-y"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1007\/s00425-017-2812-7"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201700621"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1039\/c39770000636"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1007\/BF00269293"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/np50010a002"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1101\/2025.01.07.631695"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1101\/2024.09.23.614470"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c08107"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.14346"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1007\/s00425-017-2775-8"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19690520326"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-018-0078-4"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(01)00435-7"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-34935"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst010"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4285"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msu300"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msx281"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1093\/sysbio\/syq010"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1101\/2025.01.23.634628"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1101\/2024.12.13.628308"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.5c00234","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.5c00234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T08:11:09Z","timestamp":1751357469000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.5c00234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,19]]},"references-count":76,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,7,1]]}},"alternative-id":["10.1021\/acs.biochem.5c00234"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.5c00234","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,19]]}}}