{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T08:58:20Z","timestamp":1775552300014,"version":"3.50.1"},"reference-count":90,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["RO1 AI056312"],"award-info":[{"award-number":["RO1 AI056312"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2026,4,7]]},"DOI":"10.1021\/acs.biochem.5c00802","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:09:25Z","timestamp":1773230965000},"page":"1033-1046","source":"Crossref","is-referenced-by-count":0,"title":["<i>Plasmodium falciparum<\/i>\n                    Chloroquine Resistance Transporter (PfCRT) Is a Redox-Dependent Drug Transporter"],"prefix":"10.1021","volume":"65","author":[{"given":"Darius","family":"Chernitsky-Hamd","sequence":"first","affiliation":[{"name":"Dept. of Chemistry and Dept. of Biochemistry and Cellular and Molecular Biology, Georgetown University, 37th and O Streets NW, Washington, D.C. 20057, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajat","family":"Roy","sequence":"additional","affiliation":[{"name":"Dept. of Chemistry and Dept. of Biochemistry and Cellular and Molecular Biology, Georgetown University, 37th and O Streets NW, Washington, D.C. 20057, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Schemm","sequence":"additional","affiliation":[{"name":"Dept. of Chemistry and Dept. of Biochemistry and Cellular and Molecular Biology, Georgetown University, 37th and O Streets NW, Washington, D.C. 20057, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0908-7997","authenticated-orcid":true,"given":"Aubrey","family":"Schall","sequence":"additional","affiliation":[{"name":"Dept. of Chemistry and Dept. of Biochemistry and Cellular and Molecular Biology, Georgetown University, 37th and O Streets NW, Washington, D.C. 20057, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mera","family":"Petros","sequence":"additional","affiliation":[{"name":"Dept. of Chemistry and Dept. of Biochemistry and Cellular and Molecular Biology, Georgetown University, 37th and O Streets NW, Washington, D.C. 20057, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Willems","sequence":"additional","affiliation":[{"name":"Dept. of Chemistry and Dept. of Biochemistry and Cellular and Molecular Biology, Georgetown University, 37th and O Streets NW, Washington, D.C. 20057, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7079-3793","authenticated-orcid":true,"given":"Paul D.","family":"Roepe","sequence":"additional","affiliation":[{"name":"Dept. of Chemistry and Dept. of Biochemistry and Cellular and Molecular Biology, Georgetown University, 37th and O Streets NW, Washington, D.C. 20057, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1795-x"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37870-6"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.8b00959"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/bi200922g"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/bi400557x"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/bi101638n"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/bi901035j"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/bi901034r"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.4c00750"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2021.05.007"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00857-16"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/ar020227u"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(02)00194-7"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2003.063"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.42.24876"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1179\/135100003225002907"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(98)00184-1"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2003.09.011"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.023713"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M502937200"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.116483"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2011.10.002"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/jof7010002"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01221-8"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606411103"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056792"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.2c00669"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67230-z"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1238-1"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.2144\/btn-2022-0085"},{"key":"ref32\/cit32","unstructured":"NEBaseChanger\n                      https:\/\/nebasechanger.neb.com\/ (accessed 2025\u201304\u201303)."},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.0c00247"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00412"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17781-6"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4625"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913689107"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2024.11.304"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.107.117689"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2006.01.047"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1515\/labmed-2019-0098"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/bi981929n"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-3668-8"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.6026\/97320630081230"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/jm400282d"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02137-20"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/bi8010658"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39969-2"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(02)00156-4"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2018.04.009"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2510"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/bi700152b"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307818200"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/bi034459s"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.574996"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.17.4493"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.3.1038"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136997"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9187-7_5"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300103200"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08-10-1062"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.288316"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601909"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.14340"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.12422"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1101\/2025.01.14.632917"},{"key":"ref67\/cit67","volume-title":"Quantitative Chemical Analysis","author":"Harris D. C.","year":"2010"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2012.12.014"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1021\/ed074p1195"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.11.013"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1021\/bi961801a"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201600391"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4868"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1021\/cr300163e"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R113.462929"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.02.019"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201602074"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M900580200"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1540-0"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1038\/nature06414"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2020-0266"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601799"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1021\/bi0603064"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)66737-7"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9187-7"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.REV118.005604"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3519"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200402120"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2007.10.013"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175667"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.5c00802","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.5c00802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T08:10:53Z","timestamp":1775549453000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.5c00802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":90,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,4,7]]}},"alternative-id":["10.1021\/acs.biochem.5c00802"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.5c00802","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,11]]}}}