{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:42:38Z","timestamp":1760784158705,"version":"3.37.3"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"40","funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI090048"],"award-info":[{"award-number":["AI090048"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2016,10,11]]},"DOI":"10.1021\/acs.biochem.6b00770","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T20:30:45Z","timestamp":1473712245000},"page":"5726-5737","source":"Crossref","is-referenced-by-count":11,"title":["Expanding Aminoglycoside Resistance Enzyme Regiospecificity by Mutation and Truncation"],"prefix":"10.1021","volume":"55","author":[{"given":"Selina Y. L.","family":"Holbrook","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical\rSciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0596, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Garneau-Tsodikova","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical\rSciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0596, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.3.430-450.2003"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/cr0301088"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1039\/C4MD00163J"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200900779"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073843"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2010.110"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/srep17070"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01375"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00229-15"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5b00248"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100012"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2008.08.010"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-006-0045-5"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0282OC"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.59"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.2147\/CPAA.S44377"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1039\/C5MD00344J"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.13.80"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2010.08.003"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/bi0256680"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1110\/ps.0233503"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/bi060723g"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.416453"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201300359"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105379108"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092370"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201100332"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907925106"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/bi3004473"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1039\/c2mb25341k"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/bi4002985"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00244"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.5b00036"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.57.679"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/41.4.495"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2000.tb09302.x"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.186.67"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200900584"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/bi049135y"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1107\/S1399004714017635"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1107\/S1399004714005331"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(99)80006-4"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211680200"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.49.458"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.51.735"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.52.889"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.6b00770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T19:55:51Z","timestamp":1681674951000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.6b00770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,26]]},"references-count":46,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2016,10,11]]}},"alternative-id":["10.1021\/acs.biochem.6b00770"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.6b00770","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"type":"print","value":"0006-2960"},{"type":"electronic","value":"1520-4995"}],"subject":[],"published":{"date-parts":[[2016,9,26]]}}}