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Amyloid-like assemblies formed by short, 7- and 8-residue peptides allow for pKa modulation of amino groups by more than 3 units, akin to what is observed in natural proteins, to support efficient catalysis. Our results further highlight the role that peptide assemblies might have played during the evolution of enzymatic function and, from a more applied perspective, will facilitate the development of new catalytic nanomaterials capable of promoting complex chemical transformations.<\/jats:p>","DOI":"10.1021\/acs.biochem.6c00380","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:13:21Z","timestamp":1788412401000},"page":"2835-2840","source":"Crossref","is-referenced-by-count":0,"title":["Supramolecular Peptide Assemblies Efficiently Catalyze\nthe Retroaldol Reaction"],"prefix":"10.1021","volume":"65","author":[{"given":"Charitha J.","family":"Abeygunawardena","sequence":"first","affiliation":[{"name":"Baylor University , , One Bear Place , , ,","place":["Waco, Texas, United States, 76798"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5698-4841","authenticated-orcid":true,"given":"Liam R.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Baylor University , , One Bear Place , , ,","place":["Waco, Texas, United States, 76798"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8144-783X","authenticated-orcid":true,"given":"Ivan V.","family":"Korendovych","sequence":"additional","affiliation":[{"name":"Baylor University , , One Bear Place , , ,","place":["Waco, Texas, United States, 76798"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"2026091508065454000_cit1","doi-asserted-by":"publisher","first-page":"14274","DOI":"10.1073\/pnas.251555398","article-title":"Enzyme-like proteins\nby computational design","volume":"98","author":"Bolon","year":"2001","journal-title":"Proc. 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