{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:17:40Z","timestamp":1788434260666,"version":"build-2803163510"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"17","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019180","name":"HORIZON EUROPE European Research Council","doi-asserted-by":"publisher","award":["101098234"],"award-info":[{"award-number":["101098234"]}],"id":[{"id":"10.13039\/100019180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["OCenW.M20.200"],"award-info":[{"award-number":["OCenW.M20.200"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Molecular glues (MGs) stabilize protein\u2013protein interactions (PPIs) through interactions at composite binding interfaces, thereby promoting cooperative ternary complex formation. For hub proteins that engage in multiple PPIs with widely varying intrinsic affinities, the interplay between binary PPI affinity and MG cooperativity is therefore a key determinant of selective stabilization. Here, we use the multiclient 14\u20133\u20133 scaffold protein as a model system to systematically dissect the relationship between binary 14\u20133\u20133\/client affinity (KDI) and MG-induced cooperativity (\u03b1). Client peptide affinity was systematically tuned by modifying residues N-terminal to the phosphorylated 14\u20133\u20133 binding motif while preserving the C-terminal composite interface required for MG recognition. Using a combination of biophysical techniques and protein crystallography, we show that changes in KDI alter the thermodynamic and kinetic parameters of both binary and ternary complex formation, but do not affect MG cooperativity. This principle was observed for the noncovalent MG fusicoccin-A as well as covalent MGs targeting 14\u20133\u20133\u03c3\/client complexes. Competitive binding experiments and thermodynamic modeling further revealed that, although \u03b1 is independent of KDI, the interplay between KDI, MG affinity (KDII), and cooperativity determines which PPIs are preferentially stabilized in a multiclient environment. Together, these findings establish cooperativity, intrinsic PPI affinity, and MG affinity as key parameters governing MG activity and selectivity, providing a framework for the rational design of MGs targeting hub protein interactomes.<\/jats:p>","DOI":"10.1021\/acs.biochem.6c00427","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:01:59Z","timestamp":1786968119000},"page":"2769-2783","source":"Crossref","is-referenced-by-count":0,"title":["A Molecular Mechanistic Deep Dive into 14\u20133\u20133\nMolecular Glue Cooperativity"],"prefix":"10.1021","volume":"65","author":[{"given":"Marloes A. M.","family":"Pennings","sequence":"first","affiliation":[{"name":"Eindhoven University of Technology , , ,","place":["Eindhoven, The Netherlands, 5600MB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmee M. F.","family":"Vandenboorn-Bo\u0308nner","sequence":"additional","affiliation":[{"name":"Eindhoven University of Technology , , ,","place":["Eindhoven, The Netherlands, 5600MB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Nooren","sequence":"additional","affiliation":[{"name":"Eindhoven University of Technology , , ,","place":["Eindhoven, The Netherlands, 5600MB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5972-4140","authenticated-orcid":true,"given":"Markella","family":"Konstantinidou","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["San Francisco, California, United States, 94143"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Altobelli","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["San Francisco, California, United States, 94143"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7315-0315","authenticated-orcid":true,"given":"Christian","family":"Ottmann","sequence":"additional","affiliation":[{"name":"Eindhoven University of Technology , , ,","place":["Eindhoven, The Netherlands, 5600MB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6025-9557","authenticated-orcid":true,"given":"Albert J.","family":"Markvoort","sequence":"additional","affiliation":[{"name":"Eindhoven University of Technology , , ,","place":["Eindhoven, The Netherlands, 5600MB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galen P.","family":"Miley","sequence":"additional","affiliation":[{"name":"Eindhoven University of Technology , , ,","place":["Eindhoven, The Netherlands, 5600MB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9366-6770","authenticated-orcid":true,"given":"Michelle R.","family":"Arkin","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["San Francisco, California, United States, 94143"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5675-511X","authenticated-orcid":true,"given":"Luc","family":"Brunsveld","sequence":"additional","affiliation":[{"name":"Eindhoven University of Technology , , ,","place":["Eindhoven, The Netherlands, 5600MB"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"issue":"1","key":"2026090306413863000_cit1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/s41392-024-02036-3","article-title":"New Insights into Protein\u2013Protein\nInteraction Modulators in\nDrug Discovery and Therapeutic Advance","volume":"9","author":"Nada","year":"2024","journal-title":"Signal\nTransduction Targeted Ther."},{"issue":"9","key":"2026090306413863000_cit2","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.chembiol.2014.09.001","article-title":"Small-Molecule Inhibitors\nof Protein-Protein\nInteractions: Progressing toward the Reality","volume":"21","author":"Arkin","year":"2014","journal-title":"Chem. Biol."},{"issue":"5","key":"2026090306413863000_cit3","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1021\/acscentsci.3c00003","article-title":"What Makes\na Good Protein\u2013Protein Interaction\nStabilizer: Analysis and Application of the Dual-Binding Mechanism","volume":"9","author":"Chen","year":"2023","journal-title":"ACS Cent. Sci."},{"issue":"6","key":"2026090306413863000_cit4","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.chembiol.2024.04.002","article-title":"Molecular Glues\nfor Protein-Protein Interactions: Progressing\ntoward a New Dream","volume":"31","author":"Konstantinidou","year":"2024","journal-title":"Cell Chem. Biol."},{"issue":"3","key":"2026090306413863000_cit5","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1021\/acs.biochem.2c00245","article-title":"Molecular Glues: The Adhesive Connecting Targeted Protein\nDegradation to the Clinic","volume":"62","author":"Sasso","year":"2023","journal-title":"Biochemistry"},{"issue":"7","key":"2026090306413863000_cit6","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.chembiol.2021.04.009","article-title":"Haven\u2019t Got a Glue: Protein Surface Variation\nfor the Design of Molecular Glue Degraders","volume":"28","author":"Kozicka","year":"2021","journal-title":"Cell Chem. Biol."},{"issue":"1","key":"2026090306413863000_cit7","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/s41392-025-02493-4","article-title":"mTOR Signaling\nNetworks: Mechanistic Insights and Translational Frontiers in Disease\nTherapeutics","volume":"10","author":"Zhang","year":"2025","journal-title":"Signal Transduction Targeted Ther."},{"issue":"6659","key":"2026090306413863000_cit8","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1126\/science.adg9652","article-title":"Chemical Remodeling\nof a Cellular Chaperone to Target the Active State of Mutant KRAS","volume":"381","author":"Schulze","year":"2023","journal-title":"Science"},{"issue":"10","key":"2026090306413863000_cit9","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202500048","article-title":"Nondegradative Synthetic Molecular\nGlues Enter the Clinic","volume":"20","author":"Repity","year":"2025","journal-title":"ChemMedChem"},{"issue":"10","key":"2026090306413863000_cit10","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1039\/C8SC05242E","article-title":"Cooperativity basis for small-molecule\nstabilization of protein\u2013protein interactions","volume":"10","author":"de Vink","year":"2019","journal-title":"Chem. Sci."},{"issue":"45","key":"2026090306413863000_cit11","doi-asserted-by":"publisher","first-page":"15280","DOI":"10.1074\/jbc.RA120.014715","article-title":"A Suite of\nMathematical Solutions to Describe Ternary Complex Formation and Their\nApplication to Targeted Protein Degradation by Heterobifunctional\nLigands","volume":"295","author":"Han","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"16","key":"2026090306413863000_cit12","doi-asserted-by":"publisher","first-page":"6092","DOI":"10.1021\/ja311795d","article-title":"A Comprehensive\nMathematical Model for Three-Body Binding Equilibria","volume":"135","author":"Douglass","year":"2013","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"2026090306413863000_cit13","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1039\/D2CB00211F","article-title":"Straightforward Model Construction\nand Analysis of\nMulticomponent Biomolecular Systems in Equilibrium","volume":"4","author":"Geertjens","year":"2023","journal-title":"RSC Chem. Biol."},{"issue":"42","key":"2026090306413863000_cit14","doi-asserted-by":"publisher","first-page":"23281","DOI":"10.1021\/jacs.3c08307","article-title":"Rational\nScreening for Cooperativity in Small-Molecule Inducers of Protein-Protein\nAssociations","volume":"145","author":"Liu","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"2026090306413863000_cit15","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1038\/s41467-019-09358-9","article-title":"Prospective Discovery\nof Small Molecule Enhancers of an E3 Ligase-Substrate Interaction","volume":"10","author":"Simonetta","year":"2019","journal-title":"Nat. Commun."},{"issue":"3","key":"2026090306413863000_cit16","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1039\/D2CB00207H","article-title":"Protein\u2013Protein\nInterfaces in Molecular Glue-Induced Ternary Complexes: Classification,\nCharacterization, and Prediction","volume":"4","author":"Rui","year":"2023","journal-title":"RSC Chem.\nBiol."},{"issue":"1","key":"2026090306413863000_cit17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.cell.2020.12.020","article-title":"The Rise\nof Molecular Glues","volume":"184","author":"Schreiber","year":"2021","journal-title":"Cell"},{"issue":"14","key":"2026090306413863000_cit18","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202400214","article-title":"14\u20133-3 Protein-Protein Interactions:\nFrom Mechanistic\nUnderstanding to Their Small-Molecule Stabilization","volume":"25","author":"Somsen","year":"2024","journal-title":"ChemBioChem"},{"key":"2026090306413863000_cit19","doi-asserted-by":"publisher","first-page":"1016071","DOI":"10.3389\/fmolb.2022.1016071","article-title":"Structural Insights\ninto the Functional Roles of 14\u20133-3 Proteins","volume":"9","author":"Obsilova","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"2026090306413863000_cit20","doi-asserted-by":"publisher","first-page":"1043673","DOI":"10.3389\/fmolb.2022.1043673","article-title":"Contemporary Biophysical Approaches\nfor Studying 14\u20133-3 Protein-Protein Interactions","volume":"9","author":"Thurairajah","year":"2022","journal-title":"Front. Mol. Biosci."},{"issue":"22","key":"2026090306413863000_cit21","doi-asserted-by":"publisher","first-page":"8894","DOI":"10.1073\/pnas.1220809110","article-title":"Interaction of 14\u20133-3\nProteins with the Estrogen Receptor Alpha F Domain Provides a Drug\nTarget Interface","volume":"110","author":"De Vries-van Leeuwen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.\nS. A."},{"issue":"37","key":"2026090306413863000_cit22","doi-asserted-by":"publisher","first-page":"20328","DOI":"10.1021\/jacs.3c05161","article-title":"Structure-Based\nOptimization of Covalent, Small-Molecule Stabilizers of the 14\u20133-3\u03c3\/ER\u03b1\nProtein\u2013Protein Interaction from Nonselective Fragments","volume":"145","author":"Konstantinidou","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"2026090306413863000_cit23","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/s41420-020-00362-3","article-title":"Regulation of P53\nby the 14\u20133-3 Protein Interaction Network: New Opportunities\nfor Drug Discovery in Cancer","volume":"6","author":"Falcicchio","year":"2020","journal-title":"Cell Death Discovery"},{"issue":"1","key":"2026090306413863000_cit24","doi-asserted-by":"publisher","first-page":"8150","DOI":"10.1038\/s41467-025-63227-2","article-title":"Cryo-EM Structures\nof CRAF\/MEK1\/14\u20133-3 Complexes\nin Autoinhibited and Open-Monomer States Reveal Features of RAF Regulation","volume":"16","author":"Jang","year":"2025","journal-title":"Nat. Commun."},{"issue":"9","key":"2026090306413863000_cit25","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1021\/cb4003464","article-title":"Stabilization\nof Physical RAF\/14\u20133-3 Interaction by Cotylenin A as Treatment\nStrategy for RAS Mutant Cancers","volume":"8","author":"Molzan","year":"2013","journal-title":"ACS Chem. Biol."},{"issue":"5","key":"2026090306413863000_cit26","doi-asserted-by":"publisher","first-page":"4951","DOI":"10.1021\/jacs.5c12622","article-title":"Modulation of the\n14\u20133-3\u03c3\/C-RAF \u201cAuto\u201dInhibited Complex by\nMolecular Glues","volume":"148","author":"Konstantinidou","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026090306413863000_cit27","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1038\/s42003-025-08548-0","article-title":"Stoichiometric 14\u20133-3\u03b6\nbinding promotes phospho-Tau microtubule dissociation and reduces\naggregation and condensation","volume":"8","author":"Hochmair","year":"2025","journal-title":"Commun. Biol."},{"issue":"6","key":"2026090306413863000_cit28","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1111\/febs.15574","article-title":"Phosphorylated Full-Length Tau Interacts with 14\u20133-3\nProteins via Two Short Phosphorylated Sequences, Each Occupying a\nBinding Groove of 14\u20133-3 Dimer","volume":"288","author":"Neves","year":"2021","journal-title":"FEBS\nJ."},{"issue":"1","key":"2026090306413863000_cit29","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1038\/s41467-025-57241-7","article-title":"Molecular Glues of the Regulatory\nChREBP\/14\u20133-3 Complex Protect Beta Cells from Glucolipotoxicity","volume":"16","author":"Katz","year":"2025","journal-title":"Nat. Commun."},{"issue":"9","key":"2026090306413863000_cit30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1516631113","article-title":"Characterization and\nSmall-Molecule Stabilization\nof the Multisite Tandem Binding between 14\u20133-3 and the R Domain\nof CFTR","volume":"113","author":"Stevers","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"2026090306413863000_cit31","doi-asserted-by":"publisher","first-page":"3586","DOI":"10.1038\/s41467-022-31206-6","article-title":"Macrocycle-Stabilization of Its Interaction\nwith 14\u20133-3\nIncreases Plasma Membrane Localization and Activity of CFTR","volume":"13","author":"Stevers","year":"2022","journal-title":"Nat. Commun."},{"key":"2026090306413863000_cit32","doi-asserted-by":"publisher","first-page":"102822","DOI":"10.1016\/j.sbi.2024.102822","article-title":"Harnessing the 14\u20133-3 Protein\u2013Protein\nInteraction Network","volume":"86","author":"Pitasse-Santos","year":"2024","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"11","key":"2026090306413863000_cit33","doi-asserted-by":"publisher","first-page":"2972","DOI":"10.1021\/acschembio.2c00299","article-title":"Fusicoccin-A\nTargets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing\na C-Terminal Interaction with 14\u20133-3","volume":"17","author":"Brink","year":"2022","journal-title":"ACS Chem. Biol."},{"key":"2026090306413863000_cit34","doi-asserted-by":"publisher","first-page":"106166","DOI":"10.1016\/j.nbd.2023.106166","article-title":"Stabilization of 14\u20133-3\nProtein-Protein Interactions with Fusicoccin-A Decreases Alpha-Synuclein\nDependent Cell-Autonomous Death in Neuronal and Mouse Models","volume":"183","author":"Vinueza-Gavilanes","year":"2023","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"2026090306413863000_cit35","doi-asserted-by":"publisher","first-page":"3954","DOI":"10.1038\/s41467-020-17741-0","article-title":"Structure-Based Evolution\nof a Promiscuous Inhibitor to a Selective Stabilizer of Protein\u2013Protein\nInteractions","volume":"11","author":"Sijbesma","year":"2020","journal-title":"Nat. Commun."},{"issue":"22","key":"2026090306413863000_cit36","doi-asserted-by":"publisher","first-page":"8454","DOI":"10.1021\/jacs.1c03035","article-title":"Reversible\nCovalent Imine-Tethering\nfor Selective Stabilization of 14\u20133-3 Hub Protein Interactions","volume":"143","author":"Cossar","year":"2021","journal-title":"J. Am. Chem. Soc."},{"issue":"48","key":"2026090306413863000_cit37","doi-asserted-by":"publisher","first-page":"21520","DOI":"10.1002\/anie.202008585","article-title":"Fragment-Based Stabilizers\nof Protein-Protein\nInteractions through Imine-Based Tethering","volume":"59","author":"Wolter","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"issue":"5","key":"2026090306413863000_cit38","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1039\/D4MD00833B","article-title":"Site-Specific Molecular Glues for the 14\u20133-3\/Tau\npS214 Protein\u2013Protein Interaction via Reversible Covalent Imine\nTethering","volume":"16","author":"Oberheide","year":"2025","journal-title":"RSC Med. Chem."},{"issue":"6","key":"2026090306413863000_cit39","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1021\/acsmedchemlett.1c00088","article-title":"Exploration of a 14\u20133-3\nPPI Pocket by Covalent Fragments as Stabilizers","volume":"12","author":"Sijbesma","year":"2021","journal-title":"ACS Med. Chem. Lett."},{"issue":"1","key":"2026090306413863000_cit40","doi-asserted-by":"publisher","first-page":"6467","DOI":"10.1038\/s41467-025-61176-4","article-title":"Scaffold-Hopping\nfor Molecular Glues Targeting the 14\u20133-3\/ER\u03b1 Complex","volume":"16","author":"Konstantinidou","year":"2025","journal-title":"Nat. Commun."},{"issue":"6","key":"2026090306413863000_cit41","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202521678","article-title":"Macrocyclic Molecular Glues for the\n14\u20133-3\/ChREBP Interaction: Affinity and Cooperativity in an\nInverse Relationship","volume":"65","author":"Pennings","year":"2026","journal-title":"Angew. Chem., Int. Ed."},{"issue":"7","key":"2026090306413863000_cit42","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/S0092-8674(00)80487-0","article-title":"The Structural\nBasis for 14\u20133-3: Phosphopeptide Binding Specificity","volume":"91","author":"Yaffe","year":"1997","journal-title":"Cell"},{"issue":"Pt 1","key":"2026090306413863000_cit43","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1042\/BJ20091834","article-title":"Bioinformatic and Experimental Survey\nof 14\u20133-3-Binding\nSites","volume":"427","author":"Johnson","year":"2010","journal-title":"Biochem. J."},{"issue":"5","key":"2026090306413863000_cit44","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1093\/emboj\/cdg104","article-title":"Structural View of\na Fungal Toxin Acting on a 14\u20133-3 Regulatory Complex","volume":"22","author":"Wu\u0308rtele","year":"2003","journal-title":"EMBO J."},{"issue":"7","key":"2026090306413863000_cit45","doi-asserted-by":"publisher","first-page":"104855","DOI":"10.1016\/j.jbc.2023.104855","article-title":"Molecular Basis and Dual Ligand Regulation\nof Tetrameric Estrogen Receptor \u03b1\/14\u20133-3\u03b6 Protein\nComplex","volume":"299","author":"Somsen","year":"2023","journal-title":"J. Biol. Chem."},{"issue":"11","key":"2026090306413863000_cit46","doi-asserted-by":"publisher","first-page":"3060","DOI":"10.1021\/acschembio.0c00821","article-title":"Stabilization of Protein\u2013Protein Interactions between CaMKK2\nand 14\u20133\u20133 by Fusicoccins","volume":"15","author":"Lentini Santo","year":"2020","journal-title":"ACS\nChem. Biol."},{"issue":"2","key":"2026090306413863000_cit47","doi-asserted-by":"publisher","first-page":"105651","DOI":"10.1016\/j.jbc.2024.105651","article-title":"Characterizing\nthe Protein\u2013Protein Interaction between MDM2 and 14\u20133-3\u03c3;\nProof of Concept for Small Molecule Stabilization","volume":"300","author":"Ward","year":"2024","journal-title":"J. Biol. Chem."},{"issue":"41","key":"2026090306413863000_cit48","doi-asserted-by":"publisher","first-page":"13470","DOI":"10.1002\/anie.201806584","article-title":"Rationally\nDesigned\nSemisynthetic Natural Product Analogues for Stabilization of 14\u20133-3\nProtein\u2013Protein Interactions","volume":"57","author":"Andrei","year":"2018","journal-title":"Angew.\nChem., Int. Ed."},{"issue":"42","key":"2026090306413863000_cit49","doi-asserted-by":"publisher","first-page":"5587","DOI":"10.1038\/s41388-018-0348-3","article-title":"The Dynamic and\nStress-Adaptive Signaling Hub of 14\u20133-3: Emerging Mechanisms\nof Regulation and Context-Dependent Protein\u2013Protein Interactions","volume":"37","author":"Pennington","year":"2018","journal-title":"Oncogene"},{"issue":"44","key":"2026090306413863000_cit50","doi-asserted-by":"publisher","first-page":"6331","DOI":"10.1038\/sj.onc.1204777","article-title":"14\u20133-3\nProteins; Bringing\nNew Definitions to Scaffolding","volume":"20","author":"Tzivion","year":"2001","journal-title":"Oncogene"},{"issue":"1","key":"2026090306413863000_cit51","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1021\/acsbiomedchemau.2c00037","article-title":"Modeling the Effect\nof Cooperativity in Ternary Complex Formation and Targeted Protein\nDegradation Mediated by Heterobifunctional Degraders","volume":"3","author":"Park","year":"2023","journal-title":"ACS Bio Med Chem Au"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.6c00427","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/bichaw\/article-pdf\/65\/17\/2769\/66616489\/acs.biochem.6c00427.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/bichaw\/article-pdf\/65\/17\/2769\/66616489\/acs.biochem.6c00427.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:41:44Z","timestamp":1788432104000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/bichaw\/article\/65\/17\/2769\/5260151\/A-Molecular-Mechanistic-Deep-Dive-into-14-3-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":51,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,8,17]]},"published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.6c00427","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]}}}