{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:50:34Z","timestamp":1792122634167,"version":"4.4.0"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"30","funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK34909"],"award-info":[{"award-number":["DK34909"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK46335"],"award-info":[{"award-number":["DK46335"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Skaggs Institute for Chemical Biology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2018,7,31]]},"DOI":"10.1021\/acs.biochem.8b00642","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T16:15:07Z","timestamp":1530720907000},"page":"4421-4430","source":"Crossref","is-referenced-by-count":47,"title":["NMR Measurements Reveal the Structural Basis of Transthyretin Destabilization by Pathogenic Mutations"],"prefix":"10.1021","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7379-314X","authenticated-orcid":true,"given":"Benjamin I.","family":"Leach","sequence":"first","affiliation":[{"name":"Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6686-1645","authenticated-orcid":true,"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8943-3395","authenticated-orcid":true,"given":"Jeffery W.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6855-3398","authenticated-orcid":true,"given":"H. Jane","family":"Dyson","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1368-0223","authenticated-orcid":true,"given":"Peter E.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00151a036"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/bi952501g"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101024200"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.01.018"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199702133360703"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202495199"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00220559"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.4078"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.2174\/092986712800269335"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(92)90075-X"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(02)38214-4"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1007\/BF00197809"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu830"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(90)90333-5"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(92)90099-S"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1993.1033"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/ja983961a"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008355631073"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2014.06.020"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnmrs.2011.02.002"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(72)90090-X"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s10858-013-9747-5"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.12956"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.659912"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.017657"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444996003307"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00471-0"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.4164"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1007\/s10858-018-0166-5"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1139\/o98-038"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/bip.10276"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1016\/S0021-9258(18)53792-3","volume":"268","author":"Hamilton J. A.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.38.24715"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(78)90368-6"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/bi00096a024"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/bi011194d"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/bi049621l"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/bi800636q"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-4622(00)00199-X"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.01.008"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b00164"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b00658"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b00649"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.131"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1126\/science.1214203"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201407323"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.8b00642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:09:45Z","timestamp":1682554185000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.8b00642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,4]]},"references-count":46,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2018,7,31]]}},"alternative-id":["10.1021\/acs.biochem.8b00642"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.8b00642","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,4]]}}}