{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:15:21Z","timestamp":1790302521167,"version":"4.1.0"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"16","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK104924"],"award-info":[{"award-number":["DK104924"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN 401946"],"award-info":[{"award-number":["RGPIN 401946"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2019,4,23]]},"DOI":"10.1021\/acs.biochem.9b00066","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T10:26:56Z","timestamp":1554114416000},"page":"2105-2115","source":"Crossref","is-referenced-by-count":10,"title":["Unveiling the Distinct Mechanisms by which Disease-Causing Mutations in the Kelch Domain of KLHL3 Disrupt the Interaction with the Acidic Motif of WNK4 through Molecular Dynamics Simulation"],"prefix":"10.1021","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6367-9247","authenticated-orcid":true,"given":"Lingyun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqi","family":"Cai","sequence":"additional","affiliation":[{"name":"Membrane Protein Disease Research Group, Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, T6G 2H7 Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Zhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Membrane Protein Disease Research Group, Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, T6G 2H7 Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1380-342X","authenticated-orcid":true,"given":"Ji-Bin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,4,1]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.8.2.93"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2001.03575.x"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062844"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M510042200"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20051180"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00440.2013"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.02.013"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/nature10814"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2218"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1111\/boc.201300069"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304592110"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121903"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20140153"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.437996"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410073200"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3063"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.04.032"},{"key":"ref18\/cit18","volume-title":"The PyMOL Molecular Graphics System","author":"DeLano W. L.","year":"2002"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1063\/1.445869"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21123"},{"key":"ref21\/cit21","unstructured":"Case, D. A., Darden, T. A., Cheatham, I. T. E., Simmerling, C. L., Wang, J., Duke, R.\nE., Luo, R., Walker, R. C., Zhang, W., Merz, K.\nM., Roberts, B., Hayik, S., Roitberg, A., Seabra, G., Swails, J., Gotz, A. W., Kolossv\u00e1ry, I., Wong, K. F., Paesani, F., Vanicek, J., Wolf, R. M., Liu, J., Wu, X., Brozell, S. R., Steinbrecher, T., Gohlke, H., Cai, Q., Ye, X., Wang, J., Hsieh, M. J., Cui, G., Roe, D.\nR., Mathew, D.\nH., Seetin, M.\nG., Salomon-Ferrer, R., Sagui, C., Babin, V., Luchko, T., Gusarov, S., Kovalenko, A., and Kollman, P. A. (2012)  AMBER 12, University of California, San Francisco."},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.08.102"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00732"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1063\/1.448118"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9991(77)90098-5"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1063\/1.470117"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360221211"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(97)78147-5"},{"key":"ref30\/cit30","unstructured":"MATLAB (2013)  MathWorks, Natick, MA."},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21618"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181342398"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9781139170840","volume-title":"Statistical methods in biology","author":"Bailey N. T. J.","year":"1995","edition":"3"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.9b00066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T22:38:33Z","timestamp":1681425513000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.9b00066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,1]]},"references-count":34,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2019,4,23]]}},"alternative-id":["10.1021\/acs.biochem.9b00066"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.9b00066","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,1]]}}}