{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:32:14Z","timestamp":1778729534154,"version":"3.51.4"},"reference-count":71,"publisher":"American Chemical Society (ACS)","issue":"50","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Det Frie Forskningsr??d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF15OC0016670"],"award-info":[{"award-number":["NNF15OC0016670"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008398","name":"Villum Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["2015-2666"],"award-info":[{"award-number":["2015-2666"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2019,12,17]]},"DOI":"10.1021\/acs.biochem.9b00925","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T21:25:40Z","timestamp":1574285140000},"page":"5052-5065","source":"Crossref","is-referenced-by-count":15,"title":["Distinct \u03b1-Synuclein:Lipid Co-Structure Complexes Affect Amyloid Nucleation through Fibril Mimetic Behavior"],"prefix":"10.1021","volume":"58","author":[{"given":"Ersoy","family":"Cholak","sequence":"first","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia","family":"Bucciarelli","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrine","family":"Bugge","sequence":"additional","affiliation":[{"name":"Structural Biology and NMR Laboratory, The Linderstr\u00f8m-Lang Centre for Protein Science, and REPIN, Department of Biology, Faculty of Science, University of Copenhagen, 2200 Copenhagen N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8596-548X","authenticated-orcid":true,"given":"Nicolai Tidemand","family":"Johansen","sequence":"additional","affiliation":[{"name":"Structural Biophysics, Niels Bohr Institute, Faculty of Science, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6694-0626","authenticated-orcid":true,"given":"Lise","family":"Arleth","sequence":"additional","affiliation":[{"name":"Structural Biophysics, Niels Bohr Institute, Faculty of Science, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birthe B.","family":"Kragelund","sequence":"additional","affiliation":[{"name":"Structural Biology and NMR Laboratory, The Linderstr\u00f8m-Lang Centre for Protein Science, and REPIN, Department of Biology, Faculty of Science, University of Copenhagen, 2200 Copenhagen N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2467-4205","authenticated-orcid":true,"given":"Annette E.","family":"Langkilde","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-08-02804.1988"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-007-0014-9"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/bi961799n"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2003.10506918"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.4538"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.16.9443"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.4161\/cib.3.2.10964"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/srep27125"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00592"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.09.004"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06900.x"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8329-y"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nm1066"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12303"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6469"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7527"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0423-2"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-245852"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70213-1"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.4161\/pri.23806"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah3374"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004345200"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.5607\/en.2014.23.4.292"},{"key":"ref24\/ref24_1","doi-asserted-by":"crossref","unstructured":"Cholak, E., Bugge, K., Khondker, A., Gauger, K., Pedraz-Cuesta, E., Pedersen, M. E., Bucciarelli, S., Vestergaard, B., Pedersen, S. F., Rheinst\u00e4dter, M. C., Langkilde, A. E., and Kragelund, B. B. (2019) Avidity within the N-terminal anchor drives \u03b1-synuclein membrane interaction and insertion. Submitted for publication.","DOI":"10.1096\/fj.202000107R"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.05.066"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507624200"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411805200"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.224055"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M213128200"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210136200"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.042308.113313"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200906670"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/bi061749a"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.202937"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601899113"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1750"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/cn400066t"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.585703"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.105.079251"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077235"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/ja209019s"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.707968"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1515\/ntrev-2016-0062"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2019.02.009"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12563"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090439"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/biot.200700217"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.03.021"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.726612"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.383711"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/bi300642h"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002780"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103727"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(93)90150-8"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1007\/BF02668129"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1007\/s00249-017-1232-8"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1107\/S160057671500254X"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3358"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889810026257"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.12.4278"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1039\/C4CP05563B"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.108.132662"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.75.101304.123901"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107045200"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.512459"},{"key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1096\/fasebj.31.1_supplement.926.9","volume":"31","author":"Busch F. M.","year":"2017","journal-title":"FASEB J."},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S14615"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403643101"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0720"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.07.028"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-171103"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.9b00925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T12:19:46Z","timestamp":1722082786000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biochem.9b00925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,20]]},"references-count":71,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2019,12,17]]}},"alternative-id":["10.1021\/acs.biochem.9b00925"],"URL":"https:\/\/doi.org\/10.1021\/acs.biochem.9b00925","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,20]]}}}