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In this work, a bilayer matrix was fabricated by electrospinning of a hybrid cellulose acetate nanofibers (CA) containing bioactive latex or Ciprofloxacin over highly interconnected collagen (CSPG) 3D matrix previously obtained by a freeze-drying process. The bilayer matrix was fabricated with a nanofibrous part as the primary (top) layer and a spongy porous part as the secondary (bottom) layer by combining electrospinning and freeze-drying techniques to enhance the synergistic effect of both materials corresponding to physical and biological properties. The final material was physicochemically characterized using Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The bilayer matrix exhibited nanofibrous and 3D porous structure with properties such as high porosity, swelling, and stability required for soft-tissue-engineering applications. Furthermore, the in vitro biological and fluorescence properties of the matrix were tested against NIH 3T3 fibroblast and human keratinocyte (HaCaT) cell lines and showed good cell adhesion and proliferation over the bilayer matrix. Thus, the synergistic combination of nanofibrous material deposition onto to the collagenous porous material has proved efficient in the fabrication of a bilayer matrix for skin-tissue-engineering applications.<\/jats:p>","DOI":"10.1021\/acs.biomac.0c00516","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T18:48:30Z","timestamp":1588099710000},"page":"2512-2524","source":"Crossref","is-referenced-by-count":84,"title":["Fabrication of Biohybrid Cellulose Acetate-Collagen\nBilayer Matrices as Nanofibrous Spongy Dressing Material for Wound-Healing\nApplication"],"prefix":"10.1021","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2541-6577","authenticated-orcid":true,"given":"Giriprasath","family":"Ramanathan","sequence":"first","affiliation":[{"name":"CSIR-Central Leather Research Institute (CLRI) , , ,","place":["Adyar, Chennai, India"]},{"name":"KU Leuven , , Celestijnenlaan 200F bus 2424 , ,","place":["Leuven, Belgium, B-3001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liji Sobhana","family":"Seleenmary Sobhanadhas","sequence":"additional","affiliation":[{"name":"Abo Akademi University , , Porthansgatan 3 , ,","place":["Abo, Finland, FI-20500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace Felciya","family":"Sekar Jeyakumar","sequence":"additional","affiliation":[{"name":"CSIR-Central Leather Research Institute (CLRI) , , ,","place":["Adyar, Chennai, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimala","family":"Devi","sequence":"additional","affiliation":[{"name":"CSIR-Central Leather Research Institute (CLRI) , , ,","place":["Adyar, Chennai, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1401-2569","authenticated-orcid":true,"given":"Uma Tiruchirapalli","family":"Sivagnanam","sequence":"additional","affiliation":[{"name":"CSIR-Central Leather Research Institute (CLRI) , , ,","place":["Adyar, Chennai, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1545-3523","authenticated-orcid":true,"given":"Pedro","family":"Fardim","sequence":"additional","affiliation":[{"name":"Abo Akademi University , , Porthansgatan 3 , ,","place":["Abo, Finland, FI-20500"]},{"name":"KU Leuven , , Celestijnenlaan 200F bus 2424 , ,","place":["Leuven, Belgium, B-3001"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"2026090120211452300_cit1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/978-81-322-2511-9_8","article-title":"Chitosan: A Potential Therapeutic\nDressing Material for Wound Healing","volume-title":"Chitin\nand Chitosan for Regenerative Medicine","author":"Archana","year":"2016"},{"key":"2026090120211452300_cit2","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.carbpol.2017.11.032","article-title":"Preparation and Characterization of Tree-like Cellulose\nNanofiber Membranes via the Electrospinning Method","volume":"183","author":"Zhang","year":"2018","journal-title":"Carbohydr. 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