{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:03:33Z","timestamp":1791925413552,"version":"4.3.4"},"reference-count":86,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2020,12,14]]},"DOI":"10.1021\/acs.biomac.0c01270","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T14:50:56Z","timestamp":1603896656000},"page":"5148-5161","source":"Crossref","is-referenced-by-count":65,"title":["Dendrimer-Mediated Targeted Delivery of Rapamycin to Tumor-Associated Macrophages Improves Systemic Treatment of Glioblastoma"],"prefix":"10.1021","volume":"21","author":[{"given":"Anjali","family":"Sharma","sequence":"first","affiliation":[{"name":"Center for Nanomedicine, Department of Ophthalmology, Wilmer Eye Institute Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, United States;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Liaw","sequence":"additional","affiliation":[{"name":"Center for Nanomedicine, Department of Ophthalmology, Wilmer Eye Institute Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, United States;"},{"name":"Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Center for Nanomedicine, Department of Ophthalmology, Wilmer Eye Institute Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, United States;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talis","family":"Spriggs","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Appiani La Rosa","sequence":"additional","affiliation":[{"name":"Center for Nanomedicine, Department of Ophthalmology, Wilmer Eye Institute Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, United States;"},{"name":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujatha","family":"Kannan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States;"},{"name":"Hugo W. Moser Research Institute at Kennedy Krieger, Inc., Baltimore, Maryland 21205, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3712-7836","authenticated-orcid":true,"given":"Rangaramanujam M.","family":"Kannan","sequence":"additional","affiliation":[{"name":"Center for Nanomedicine, Department of Ophthalmology, Wilmer Eye Institute Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, United States;"},{"name":"Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States;"},{"name":"Hugo W. Moser Research Institute at Kennedy Krieger, Inc., Baltimore, Maryland 21205, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0289"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00352"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70432-0"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.2217\/cns-2015-0008"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3794"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0760-3"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-2545"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-019-0771-8"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.2A0114-006R"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.245"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2017.06.014"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/mp400371r"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.02.053"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1039\/B901839P"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/pola.10301"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-019-2683-7"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700339"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/pola.27316"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA02713B"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1670"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.07.009"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.01.032"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.7150\/thno.29039"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/nn303472r"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.03.056"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10160"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c01033"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-1004-5"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/nn404872e"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23061419"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00261"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.7150\/thno.41714"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-075024"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.15.6710-6718.2004"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767030-00004"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.01.001"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2009.06.025"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-2684"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0106"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.5.553"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-014-1680-2"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2015.1039667"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2015.07.007"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nor050"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1510"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.06.003"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay8514"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003162"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06113-2"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10094"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2007.07.012"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/cr900249z"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/ol0514395"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.7b00569"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.04.036"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.05.044"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00693"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12126"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2017.23"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/bm3018615"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2010.10.008"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2019.03.012"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0504-5"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601515"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi113"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602162"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70262-1"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021915124064"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096239"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.10.5724"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.11.025"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S165184"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10160"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.11.044"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.2174\/138920112803341798"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0763"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2014.27"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050008"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aar4289"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.3791\/1787"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1002\/9780470942390.mo110217"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811949106"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.07.013"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nou127"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh639"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-011-0174-9"}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.0c01270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T20:32:32Z","timestamp":1682541152000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biomac.0c01270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,28]]},"references-count":86,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12,14]]}},"alternative-id":["10.1021\/acs.biomac.0c01270"],"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.0c01270","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,28]]}}}