{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:57:53Z","timestamp":1792223873279,"version":"4.4.0"},"reference-count":63,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2017-03741"],"award-info":[{"award-number":["RGPIN-2017-03741"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2022,8,8]]},"DOI":"10.1021\/acs.biomac.2c00386","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T17:07:16Z","timestamp":1657559236000},"page":"3296-3307","source":"Crossref","is-referenced-by-count":15,"title":["Changing Surface Polyethylene Glycol Architecture Affects Elongated Nanoparticle Penetration into Multicellular Tumor Spheroids"],"prefix":"10.1021","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1819-7502","authenticated-orcid":true,"given":"Megan G.","family":"Roberts","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 1H6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5909-883X","authenticated-orcid":true,"given":"Valerie J.","family":"Facca","sequence":"additional","affiliation":[{"name":"Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario M5S 3M2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Keunen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 1H6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4487-7125","authenticated-orcid":true,"given":"Qing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 1H6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1038-7993","authenticated-orcid":true,"given":"Raymond M.","family":"Reilly","sequence":"additional","affiliation":[{"name":"Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario M5S 3M2, Canada"},{"name":"Department of Medical Imaging, University of Toronto, 263 McCaul Street, Toronto, Ontario M5T 1W7, Canada"},{"name":"Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario M5G 2C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2673-2141","authenticated-orcid":true,"given":"Mitchell A.","family":"Winnik","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 1H6, Canada"},{"name":"Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/nn900002m"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.139"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(86)90018-x"},{"key":"ref4\/cit4","first-page":"6387","volume":"46","author":"Matsumura Y.","year":"1986","journal-title":"Cancer Res."},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0566-2"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c04510"},{"key":"ref7\/cit7","first-page":"4478","volume":"50","author":"Boucher Y.","year":"1990","journal-title":"Cancer Res."},{"key":"ref8\/cit8","first-page":"3039","volume":"47","author":"Jain R. K.","year":"1987","journal-title":"Cancer Res."},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-071811-150124"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.06.016"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00194"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.14"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-020-0755-z"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.10.035"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/nn406258m"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/nn200365a"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2007.70"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200801789"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2012.11.008"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/mp900022m"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.04.012"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201104449"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/mp300240m"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/mc.21844"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2236"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24683"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2010.01.012"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1039\/c7py00559h"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201702858"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-01853-8"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2016.11.002"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/bm300191k"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1021\/bk-2009-1017.ch004","volume-title":"Polysaccharide Materials: Performance by Design","volume":"1017","author":"Roman M.","year":"2009"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2014.07.025"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.04.044"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1007\/s10570-013-9954-y"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b02432"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1039\/c7tb00812k"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.6b00055"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1039\/d0nr08076d"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.9b00959"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00426"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062630"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.01.010"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b01713"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9673(00)80335-0"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.93.028301"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-70649-z"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.5b02305"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20517"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.04.029"},{"key":"ref52\/cit52","first-page":"3090","volume":"44","author":"Nederman T.","year":"1984","journal-title":"Cancer Res."},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2010.58"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.6b02163"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b02595"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1039\/c4bm00323c"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2015.08.024"},{"key":"ref58\/cit58","first-page":"2497","volume":"60","author":"Netti P. A.","year":"2000","journal-title":"Cancer Res."},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1521265113"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2012.10.003"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2012.12.003"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1021\/mp300016p"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.168906"}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.2c00386","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.2c00386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T02:32:53Z","timestamp":1682649173000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biomac.2c00386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,11]]},"references-count":63,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8,8]]}},"alternative-id":["10.1021\/acs.biomac.2c00386"],"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.2c00386","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,11]]}}}