{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T07:14:01Z","timestamp":1794035641469,"version":"4.8.0"},"reference-count":74,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51873115"],"award-info":[{"award-number":["51873115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52073190"],"award-info":[{"award-number":["52073190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52122306"],"award-info":[{"award-number":["52122306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A2098"],"award-info":[{"award-number":["U21A2098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"crossref","award":["CGZH19006"],"award-info":[{"award-number":["CGZH19006"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"crossref","award":["ZYJC21010"],"award-info":[{"award-number":["ZYJC21010"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"crossref","award":["ZYJC21014"],"award-info":[{"award-number":["ZYJC21014"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2022,9,12]]},"DOI":"10.1021\/acs.biomac.2c00583","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T17:24:30Z","timestamp":1659633870000},"page":"3728-3742","source":"Crossref","is-referenced-by-count":48,"title":["Ultraporous Polyquaternium-Carboxylated Chitosan Composite Hydrogel Spheres with Anticoagulant, Antibacterial, and Rapid Endotoxin Removal Profiles for Sepsis Treatment"],"prefix":"10.1021","volume":"23","author":[{"given":"Xianda","family":"Liu","sequence":"first","affiliation":[{"name":"College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunji","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, West China Hospital, Sichuan University, Chengdu, 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baihai","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Nephrology, West China Hospital, Sichuan University, Chengdu, 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2689-0251","authenticated-orcid":true,"given":"Weifeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4619-3499","authenticated-orcid":true,"given":"Changsheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China"},{"name":"College of Chemical Engineering, Sichuan University, Chengdu, 610065, China"},{"name":"Med-X Center for Materials, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30696-2"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i1585"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0005-7"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2011-3"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4683-6"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504-0781OC"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-6-457"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2014.10.003"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.71.110601.135414"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021333"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1097\/shk.0b013e31805363c6"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.36"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.13.1723"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2194"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1159\/000499520"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)00126-8"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.14618"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.12.035"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116470"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.01.067"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00445-3"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2021.100864"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2012.01069.x"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4891"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-020-00673-x"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.05.091"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.7b01724"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/app.13464"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2014.07.072"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.11.010"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2015.09.012"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/bm900035u"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.7b04323"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.11.075"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.06.002"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2013.12.036"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2015.03.008"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.02.010"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2019.05.023"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2018.10.088"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.apt.2021.04.004"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.128923"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2008.06.009"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/ie403956d"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2020.114523"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.05.185"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2020.117829"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-010-1034-0"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050318"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(84)90060-7"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/0162-3109(89)90051-9"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/nm1565"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-02-0126"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/mp2006054"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2008.12.008"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02710.x"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2018.00099"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02225-X"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-222109"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-002-1330-6"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1104\/pp.73.3.698"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4628(20010214)79:7<1324::AID-APP210>3.0.CO;2-L"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/bm034130m"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5464-6"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000354"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2019.01.028"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2019.116497"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1556\/amicr.49.2002.1.15"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1086\/315093"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051201"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.699418"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00037-09"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1159\/000014343"}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.2c00583","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.2c00583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T17:34:00Z","timestamp":1682616840000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biomac.2c00583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,4]]},"references-count":74,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,12]]}},"alternative-id":["10.1021\/acs.biomac.2c00583"],"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.2c00583","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,4]]}}}