{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:58:29Z","timestamp":1790632709190,"version":"4.1.0"},"reference-count":67,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U01NS103882"],"award-info":[{"award-number":["U01NS103882"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY001765"],"award-info":[{"award-number":["P30EY001765"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2023,3,13]]},"DOI":"10.1021\/acs.biomac.2c01381","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T15:36:13Z","timestamp":1677252973000},"page":"1355-1365","source":"Crossref","is-referenced-by-count":37,"title":["Targeted Microglial Attenuation through Dendrimer\u2013Drug Conjugates Improves Glaucoma Neuroprotection"],"prefix":"10.1021","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2670-9117","authenticated-orcid":true,"given":"Ian","family":"Pitha","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States"},{"name":"Center for Nanomedicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States"},{"name":"Glaucoma Center of Excellence, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siva","family":"Kambhampati","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States"},{"name":"Center for Nanomedicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States"},{"name":"Center for Nanomedicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States"},{"name":"Center for Nanomedicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"McCrea","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States"},{"name":"Center for Nanomedicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Mozzer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States"},{"name":"Center for Nanomedicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3712-7836","authenticated-orcid":true,"given":"Rangaramanujam M.","family":"Kannan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States"},{"name":"Center for Nanomedicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081224"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.6.701"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0002-9394(99)00093-8","volume":"127","author":"Leske M. C.","year":"1999","journal-title":"Am. J. Ophthalmol."},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.1.48"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.11.003"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100916"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2021.02.003"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2020.07.004"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.612422"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16177"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-021-01180-z"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105028"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0051-5"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/nature21029"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.1104"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-1136"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.8.1050"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108271"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22516"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2016.01.014"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3791\/52731"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.018788"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-020-00603-7"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.7b00569"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1337"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040065"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2801-06.2006"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18024"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61135"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2012.0232"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-018-4219-1"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154437"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.05.035"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-16250"},{"key":"ref36\/cit36","first-page":"402","volume":"43","author":"Levkovitch-Verbin H.","year":"2002","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.7.2.13"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25303"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2018.01.002"},{"key":"ref40\/cit40","first-page":"2962","volume":"43","author":"Naskar R.","year":"2002","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/mp400371r"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2018.05.004"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23051025"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.02.016"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.07.009"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2014.11.004"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2017.06.014"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9949453"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/nn404872e"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.12.054"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.04.050"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01984-1"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-1004-5"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003162"},{"key":"ref55\/cit55","unstructured":"Ashvattha\nTherapeutics I. A Study\nto Evaluate OP-101 (Dendrimer N-acetyl-cysteine) in Severe Coronavirus\nDisease 2019 (COVID-19) Patients 2022 [updated August 1]. Available\nfrom: https:\/\/ClinicalTrials.gov\/show\/NCT04458298."},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13050647"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030526"},{"key":"ref58\/cit58","first-page":"2217","volume":"15","author":"Lam D.","year":"2009","journal-title":"Mol. Vis."},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-4081-y"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2010943117"},{"key":"ref61\/cit61","unstructured":"Kannan\nRangaramanujam, SPK, Gerard, A. Lutty, Rishi Sharma, inventorDendrimer compositions for use in angiography patent US11160881B2. 2018."},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2010.01.009"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1126\/science.1202529"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1056-1"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100976"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211284110"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00783-4"}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.2c01381","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.2c01381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T04:47:45Z","timestamp":1678682865000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biomac.2c01381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,24]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3,13]]}},"alternative-id":["10.1021\/acs.biomac.2c01381"],"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.2c01381","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,24]]}}}