{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:08:40Z","timestamp":1787062120039,"version":"build-2736575974"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100023331","name":"LEO Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012331","name":"LEO Fondet","doi-asserted-by":"publisher","award":["LF15007"],"award-info":[{"award-number":["LF15007"]}],"id":[{"id":"10.13039\/501100012331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2016732"],"award-info":[{"award-number":["2016732"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2023,7,10]]},"DOI":"10.1021\/acs.biomac.3c00265","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T12:54:35Z","timestamp":1686574475000},"page":"3203-3214","source":"Crossref","is-referenced-by-count":13,"title":["Protease-Responsive Hydrogel Microparticles for Intradermal Drug Delivery"],"prefix":"10.1021","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0488-5227","authenticated-orcid":true,"given":"Heidi K.","family":"Noddeland","sequence":"first","affiliation":[{"name":"LEO Foundation Center for Cutaneous Drug Delivery, Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark"},{"name":"Explorative Formulation & Technologies, CMC Design and Development, LEO Pharma A\/S, 2750 Ballerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Lind","sequence":"additional","affiliation":[{"name":"Explorative Formulation & Technologies, CMC Design and Development, LEO Pharma A\/S, 2750 Ballerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Petersson","sequence":"additional","affiliation":[{"name":"Explorative Formulation & Technologies, CMC Design and Development, LEO Pharma A\/S, 2750 Ballerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0197-497X","authenticated-orcid":true,"given":"Frank","family":"Caruso","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Malmsten","sequence":"additional","affiliation":[{"name":"LEO Foundation Center for Cutaneous Drug Delivery, Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark"},{"name":"Department of Physical Chemistry 1, University of Lund, SE-22100 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8609-4460","authenticated-orcid":true,"given":"Andrea","family":"Heinz","sequence":"additional","affiliation":[{"name":"LEO Foundation Center for Cutaneous Drug Delivery, Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-020-00269-6"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax7946"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.747333"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/der2.99"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.07.002"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00698-w"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2013.11.005"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.06.003"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2015.00019"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01370"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.6.455"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2014.01.068"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2007.02378.x"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03825.x"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13275"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01810"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13919"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.06.061"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10158"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03691-1"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.71"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0148-6"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.7b00017"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.07.043"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200901808"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.12.015"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9913798"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.0c02279"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c01642"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3390\/biom12030475"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1039\/c5bm00034c"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-012-8348-5"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.11.012"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.105.061994"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-008-9562-y"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016064320334"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21350"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.11.016"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/app.41563"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13468"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.90"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.609653"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.02.021"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1134\/s102279541109016x"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155195"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-014-0347-x"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02433-x"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.09.003"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07616.x"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2011.10.006"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.17.1.463"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2020.12.020"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519831931"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1039\/c5tb00443h"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1039\/c5sm02668g"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1039\/c5bm00256g"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.3390\/polym10090970"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.09.028"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64464-9"}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.3c00265","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.3c00265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T04:11:28Z","timestamp":1688962288000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biomac.3c00265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,12]]},"references-count":59,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7,10]]}},"alternative-id":["10.1021\/acs.biomac.3c00265"],"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.3c00265","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,12]]}}}