{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:22:03Z","timestamp":1793841723710,"version":"4.6.1"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["101069308"],"award-info":[{"award-number":["101069308"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["CN00000041"],"award-info":[{"award-number":["CN00000041"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["CUP B73C22000780001"],"award-info":[{"award-number":["CUP B73C22000780001"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009887","name":"Regione Siciliana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009887","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2025,1,13]]},"DOI":"10.1021\/acs.biomac.4c00387","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T12:55:19Z","timestamp":1734008119000},"page":"163-177","source":"Crossref","is-referenced-by-count":13,"title":["Diving into RNAi Therapy: An Inhalable Formulation Based on Lipid\u2013Polymer Hybrid Systems for Pulmonary Delivery of siRNA"],"prefix":"10.1021","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6244-9183","authenticated-orcid":true,"given":"Marta","family":"Cabibbo","sequence":"first","affiliation":[{"name":"Lab of Biocompatible Polymers, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, Palermo 90123, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5209-9319","authenticated-orcid":true,"given":"Cinzia","family":"Scialabba","sequence":"additional","affiliation":[{"name":"Lab of Biocompatible Polymers, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, Palermo 90123, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0503-9559","authenticated-orcid":true,"given":"Emanuela F.","family":"Craparo","sequence":"additional","affiliation":[{"name":"Lab of Biocompatible Polymers, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, Palermo 90123, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2047-0232","authenticated-orcid":true,"given":"Simone P.","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Pharmaceutical Technology and Biopharmacy, Ludwig-Maximilians-University, Butenandtstrasse 5-13, 81337 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4151-3916","authenticated-orcid":true,"given":"Olivia M.","family":"Merkel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Pharmaceutical Technology and Biopharmacy, Ludwig-Maximilians-University, Butenandtstrasse 5-13, 81337 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0585-6564","authenticated-orcid":true,"given":"Gennara","family":"Cavallaro","sequence":"additional","affiliation":[{"name":"Lab of Biocompatible Polymers, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, Palermo 90123, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.11.005"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21571"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2014.1928"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.04.008"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2018-0029"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/VIW.20200026"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2014.05.018"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.8b00732"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.12.026"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S198353"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.09.018"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2017.1364"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c14975"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.09.001"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.02.006"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12020089"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/bc800408g"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.09.050"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2015.06.009"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.2c00576"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2023.106580"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.11.001"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.11.081"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202100073"},{"key":"ref25\/cit25","volume-title":"3 Dry Powder Inhalation for Pulmonary Delivery: Recent Advances and Continuing Challenges","author":"Carvalho S. R.","year":"2015"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.4103\/1735-5362.228958"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.01.034"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.11.020"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.08.030"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.08.004"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1039\/c3ra42069h"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1039\/D2NA00534D"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c00196"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/mp400787s"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2012.11.010"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2014.09.002"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2005.05.001"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.7150\/thno.18136"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1751036"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2015.10.021"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-018-0401-y"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119794"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-021-01102-5"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.09.021"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.05.019"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118818"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2023.11.007"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14061193"}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.4c00387","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.4c00387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T09:18:20Z","timestamp":1736759900000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biomac.4c00387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,13]]}},"alternative-id":["10.1021\/acs.biomac.4c00387"],"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.4c00387","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,12]]}}}