{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:41:35Z","timestamp":1790185295672,"version":"4.1.0"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["21KJA150007"],"award-info":[{"award-number":["21KJA150007"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013088","name":"Qinglan Project of Jiangsu Province of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51873144"],"award-info":[{"award-number":["51873144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52073195"],"award-info":[{"award-number":["52073195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52073196"],"award-info":[{"award-number":["52073196"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2024,7,8]]},"DOI":"10.1021\/acs.biomac.4c00561","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T13:26:05Z","timestamp":1718285165000},"page":"4569-4580","source":"Crossref","is-referenced-by-count":10,"title":["CXCR4-Mediated Codelivery of FLT3 and BCL-2 Inhibitors for Enhanced Targeted Combination Therapy of FLT3-ITD Acute Myeloid Leukemia"],"prefix":"10.1021","volume":"25","author":[{"given":"Jiakun","family":"Yang","sequence":"first","affiliation":[{"name":"Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumin","family":"Mao","sequence":"additional","affiliation":[{"name":"Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Chen","sequence":"additional","affiliation":[{"name":"Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0879-5069","authenticated-orcid":true,"given":"Ru","family":"Cheng","sequence":"additional","affiliation":[{"name":"Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, P. R. China"},{"name":"Soochow College, Soochow University, Suzhou 215123, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Li","sequence":"additional","affiliation":[{"name":"Orthopedic Institute, Soochow University, Suzhou 215007, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6287-1555","authenticated-orcid":true,"given":"Huanli","family":"Sun","sequence":"additional","affiliation":[{"name":"Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7697-9874","authenticated-orcid":true,"given":"Chao","family":"Deng","sequence":"additional","affiliation":[{"name":"Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4175-4741","authenticated-orcid":true,"given":"Zhiyuan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, P. R. China"},{"name":"College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,6,13]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00108-3"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00425-3"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406184"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01424-6"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26822"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202209984"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/nature07485"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014670"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.280801"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.031"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2021.100905"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/nature11016"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0357-9"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0694-3"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00509-w"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2015.17"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-03-828269"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-020-00165-6"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1007\/s44228-023-00041-x"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.244020"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00578-4"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003429"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00407-4"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115849"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-023-00911-w"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00602"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2535"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020050"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.05.014"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00355-z"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.299"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S34450"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.3.10"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.1c01103"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S104119"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3390\/polym10080895"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-017-2420-2"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.01.014"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201904742"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1007\/s40495-015-0044-8"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.26579"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2009.05.009"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204866"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-022-00283-0"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0341-y"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2021-0059"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008017"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101872"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2004.01.006"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050245"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2018.1486064"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112833"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-117258"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-009-9309-8"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909303411407"}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.4c00561","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.4c00561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T08:12:05Z","timestamp":1720426325000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biomac.4c00561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,13]]},"references-count":55,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7,8]]}},"alternative-id":["10.1021\/acs.biomac.4c00561"],"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.4c00561","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,13]]}}}