{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:07:11Z","timestamp":1793156831210,"version":"4.5.0"},"reference-count":91,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["F-2008-20220331"],"award-info":[{"award-number":["F-2008-20220331"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["402723784"],"award-info":[{"award-number":["402723784"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["MI2212\/1-1\/2"],"award-info":[{"award-number":["MI2212\/1-1\/2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PA2526\/3-1-2"],"award-info":[{"award-number":["PA2526\/3-1-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","award":["TFNUP 89410"],"award-info":[{"award-number":["TFNUP 89410"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2146549"],"award-info":[{"award-number":["2146549"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALTF 1020-2020"],"award-info":[{"award-number":["ALTF 1020-2020"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2025,4,14]]},"DOI":"10.1021\/acs.biomac.4c00609","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T07:09:02Z","timestamp":1733728142000},"page":"2060-2075","source":"Crossref","is-referenced-by-count":22,"title":["Protein-Specific Crowding Accelerates Aging in Protein Condensates"],"prefix":"10.1021","volume":"26","author":[{"given":"Mateusz","family":"Brzezinski","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of Texas at Austin, 107 W. Dean Keeton Rd., Austin, Texas 78712, United States"},{"name":"Max Planck Institute for Polymer Research Ackermannweg 10","place":["Mainz, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo G.","family":"Argudo","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Polymer Research Ackermannweg 10","place":["Mainz, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Scheidt","sequence":"additional","affiliation":[{"name":"Biocenter, Johannes Gutenberg University Mainz, Hanns-Dieter-H\u00fcsch-Weg 17, Mainz 55128, Germany"},{"name":"Institute of Molecular Biology GmbH, Ackermannweg 4, Mainz 55128, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Yu","sequence":"additional","affiliation":[{"name":"Biocenter, Johannes Gutenberg University Mainz, Hanns-Dieter-H\u00fcsch-Weg 17, Mainz 55128, Germany"},{"name":"Institute of Molecular Biology GmbH, Ackermannweg 4, Mainz 55128, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elnaz","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Texas at Austin, 107 W. Dean Keeton Rd., Austin, Texas 78712, United States"},{"name":"Max Planck Institute for Polymer Research Ackermannweg 10","place":["Mainz, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Kaltbeitzel","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Polymer Research Ackermannweg 10","place":["Mainz, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0634-0503","authenticated-orcid":true,"given":"Edward A.","family":"Lemke","sequence":"additional","affiliation":[{"name":"Biocenter, Johannes Gutenberg University Mainz, Hanns-Dieter-H\u00fcsch-Weg 17, Mainz 55128, Germany"},{"name":"Institute of Molecular Biology GmbH, Ackermannweg 4, Mainz 55128, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1591-4449","authenticated-orcid":true,"given":"Jasper J.","family":"Michels","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Polymer Research Ackermannweg 10","place":["Mainz, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8522-1854","authenticated-orcid":true,"given":"Sapun H.","family":"Parekh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Texas at Austin, 107 W. Dean Keeton Rd., Austin, Texas 78712, United States"},{"name":"Max Planck Institute for Polymer Research Ackermannweg 10","place":["Mainz, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100913-013325"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.7"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(01)01938-7"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R100005200"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB02201A"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103382108"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(91)90499-V"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2012.08.009"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/ja211115q"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2018.0032"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.1c01301"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1101\/2022.02.22.481401"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21808"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1039\/b711990a"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21237"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/polym13091489"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR02065J"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.16.8378"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.16.8399"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165908"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.047"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0589-7"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2022.12.001"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-03-0165"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.01.044"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910163107"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9101451"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.06.024"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-818084-6.00002-7"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.08.197"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071058398"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70245-3"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179207"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b09510"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314481110"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.02.010"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.212507199"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41864-9"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901669R"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2012.204"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/pj.2014.10"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-014-0479-y"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1039\/c1cp20618d"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/jf981074l"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.56530\/spectroscopy.lo2270l5"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/999\/1\/012002"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3390\/cryst10111011"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1149\/2.0581814jes"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2020.128331"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2023.09.006"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200700603"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymertesting.2019.106316"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.28"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.5b03841"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2020.129103"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201907157"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36059-1"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01353-4"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010034"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1039\/C4AN01495B"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1126\/science.119.3095.555.b"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1039\/C6CP08809K"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/ie0102201"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00814"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1810054115"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-9639(02)00414-4"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151223090"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.08.016"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2022.0042"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2018.10.010"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.2c00794"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-3055114\/v1"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn6831"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abh1448"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1101\/2023.06.02.542764"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2023.05.009"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.023.202302990"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201911782"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.2c00307"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26532-0"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2009.03.003"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2008.07.009"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3461"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.5281\/ZENODO.7648957"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.111.3.807"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky508"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts241"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6810-7_16"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1039\/C4IB00271G"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1364\/OL.34.001363"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202104247"}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.4c00609","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.4c00609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T08:49:23Z","timestamp":1744620563000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biomac.4c00609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,9]]},"references-count":91,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,14]]}},"alternative-id":["10.1021\/acs.biomac.4c00609"],"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.4c00609","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,9]]}}}