{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:47:28Z","timestamp":1786999648515,"version":"build-2736575974"},"reference-count":74,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["CZ.02.1.01\/0.0\/0.0\/18_046\/0016045"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/18_046\/0016045"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007543","name":"Grantov?? Agentura, Univerzita Karlova","doi-asserted-by":"publisher","award":["410121"],"award-info":[{"award-number":["410121"]}],"id":[{"id":"10.13039\/100007543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Czech Academy of Sciences","award":["AP2202"],"award-info":[{"award-number":["AP2202"]}]},{"DOI":"10.13039\/501100003243","name":"Ministry of Health of the Czech Republic","doi-asserted-by":"crossref","award":["AZV NU22-10-00072"],"award-info":[{"award-number":["AZV NU22-10-00072"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001823","name":"Ministry of Education, Youth and Sports (MEYS)","doi-asserted-by":"crossref","award":["CZ.02.01.01\/00\/22_008\/0004562"],"award-info":[{"award-number":["CZ.02.01.01\/00\/22_008\/0004562"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001823","name":"Ministry of Education, Youth and Sports (MEYS)","doi-asserted-by":"crossref","award":["LM2023050 Czech-BioImaging"],"award-info":[{"award-number":["LM2023050 Czech-BioImaging"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2024,10,14]]},"DOI":"10.1021\/acs.biomac.4c00653","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T20:51:00Z","timestamp":1725051060000},"page":"6485-6502","source":"Crossref","is-referenced-by-count":8,"title":["Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis"],"prefix":"10.1021","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4955-4093","authenticated-orcid":true,"given":"Martina","family":"Doubkov\u00e1","sequence":"first","affiliation":[{"name":"Laboratory of Biomaterials and Tissue Engineering, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague 4, Czech Republic"},{"name":"Second Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4607-4497","authenticated-orcid":true,"given":"Jarmila","family":"Knitlov\u00e1","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Tissue Engineering, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague 4, Czech Republic"},{"name":"Faculty of Science, Charles University, Albertov 6, 128 00 Prague 2, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6432-1012","authenticated-orcid":true,"given":"David","family":"Vondr\u00e1\u0161ek","sequence":"additional","affiliation":[{"name":"Laboratory of Biomathematics, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague 4, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4757-5226","authenticated-orcid":true,"given":"Adam","family":"Eckhardt","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Metabolism, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague 4, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-0038","authenticated-orcid":true,"given":"Tom\u00e1\u0161","family":"Novotn\u00fd","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Masaryk Hospital, Socialni Pece 3316\/12A, 401 13 Usti nad Labem, Czech Republic"},{"name":"Department of Histology and Embryology, Second Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3282-9847","authenticated-orcid":true,"given":"Martin","family":"O\u0161t\u2019\u00e1dal","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University Hospital Bulovka, Charles University, Budinova 67\/2, 180 81 Prague 8, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Filov\u00e1","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Tissue Engineering, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague 4, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1818-9484","authenticated-orcid":true,"given":"Lucie","family":"Ba\u010d\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Tissue Engineering, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague 4, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019246"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1097\/01202412-199504010-00003"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpsur.2007.04.001"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-0734-9"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2021.04.029"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1080\/17453674.2021.1982576"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-013-2033-z"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e3181b2f21d"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.17.01652"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12381"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.76B3.8175852"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-198509000-00014"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.80B4.0800641"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-200105000-00021"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-008-0692-7"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2300-3"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24211"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111903"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08519-z"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1093\/micmic\/ozac012"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1007\/s42399-020-00292-2"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2020.1816992"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.05.020"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1177\/2041731417730467"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120943"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)35645-4"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1994.1569"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.0224"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00387.x"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037904"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/srep08729"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1186\/s42490-019-0014-z"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.615774"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ac5673"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29236-6"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74179-6"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01369-1"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2013.0733"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/srep30746"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v037a19"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121674"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM00868C"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54793-9"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.756399"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201304428"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbiosy.2021.100009"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr313"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1242\/dev.160093"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2005.04.002"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(75)90106-3"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2004.06.001"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2005.02.007"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20180051"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-00934-2_30"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.02.004"},{"key":"ref57\/cit57","series-title":"Methods in Molecular Medicine","volume-title":"Methods in Molecular Medicine, Vol. 101: Cartilage and Osteoarthritis, Vol. 2: Structure and In Vivo Analysis","author":"De Ceuninck F.","year":"2004"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.03.003"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13752-y"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.910761"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.117"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/AST.96.1"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1159\/000522609"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(01)01938-7"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.104.047746"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/jp5077559"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.012062"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2021.1945527"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1159\/000248891"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb14743.x"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1186\/s40634-023-00650-8"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)45304-5"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1177\/2472555218817057"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.2c01448"}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.4c00653","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.4c00653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T04:12:00Z","timestamp":1728879120000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biomac.4c00653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,30]]},"references-count":74,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10,14]]}},"alternative-id":["10.1021\/acs.biomac.4c00653"],"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.4c00653","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,30]]}}}