{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:41:38Z","timestamp":1794004898880,"version":"4.8.0"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1205800"],"award-info":[{"award-number":["2022YFA1205800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018925","name":"Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center)","doi-asserted-by":"publisher","award":["BP0820029"],"award-info":[{"award-number":["BP0820029"]}],"id":[{"id":"10.13039\/501100018925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7242277"],"award-info":[{"award-number":["7242277"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAMS Innovation Fund for Medical Science","award":["CIFMS 2021-I2M-1-006"],"award-info":[{"award-number":["CIFMS 2021-I2M-1-006"]}]},{"name":"Haihe Laboratory of Cell Ecosystem Innovation Fund","award":["22HHXBSS00040"],"award-info":[{"award-number":["22HHXBSS00040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2025,3,10]]},"DOI":"10.1021\/acs.biomac.4c01397","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T17:20:46Z","timestamp":1738776046000},"page":"1614-1626","source":"Crossref","is-referenced-by-count":13,"title":["Iron\u2013Doxorubicin Hyaluronan Nanogel as an Effective Targeted Chemotherapy with Modulated Cardiotoxicity"],"prefix":"10.1021","volume":"26","author":[{"given":"Hua","family":"Guo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular Oncology and Department of Molecular Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital","place":["Beijing, P. R. China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Complex Severe and Rare Diseases, Institute of Basic Medical Sciences","place":["Beijing, P. R. China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Complex Severe and Rare Diseases, Institute of Basic Medical Sciences","place":["Beijing, P. R. China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Complex Severe and Rare Diseases, Institute of Basic Medical Sciences","place":["Beijing, P. R. China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6648-6195","authenticated-orcid":true,"given":"Ching-Hsuan","family":"Tung","sequence":"additional","affiliation":[{"name":"Molecular Imaging Innovations Institute, Department of Radiology","place":["New York, United States"]},{"name":"Weill Cornell Medicine","place":["New York, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4315-6809","authenticated-orcid":true,"given":"Weiqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Complex Severe and Rare Diseases, Institute of Basic Medical Sciences","place":["Beijing, P. R. China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-030620-104842"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00025"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB00551K"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2023.10.009"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.013383"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201805664"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/bi00537a001"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72931"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.05.056"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c05379"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00451"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.1c01370"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202404053"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101101"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c24066"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121585"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201810735"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.214059"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.04.106"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201400291"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.11.001"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.06.014"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b16500"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.11.011"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.32909"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.2147\/MDER.S13962"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121415"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.132074"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22071106"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(99)00040-9"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC08230K"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.01.012"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015170907274"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1039\/c3tb20906g"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201303222"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2013.05.077"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/bm300046h"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.8b00287"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c00817"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.7150\/thno.41882"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(86)90181-9"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2021.05.001"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialslett.3c01265"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.03.007"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015862108"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB02306A"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201705697"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b16575"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.05.032"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2790-3"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.647446"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.10.025"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1063871"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-01293-x"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.7b01046"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.02.002"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.122521"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1821022116"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.03.020"}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.4c01397","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.4c01397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T04:13:09Z","timestamp":1741579989000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biomac.4c01397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,10]]}},"alternative-id":["10.1021\/acs.biomac.4c01397"],"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.4c01397","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,5]]}}}