{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:11:46Z","timestamp":1777551106114,"version":"3.51.4"},"reference-count":58,"publisher":"American Chemical Society (ACS)","issue":"7","funder":[{"DOI":"10.13039\/501100007603","name":"Korea Food and Drug Administration","doi-asserted-by":"crossref","award":["13172KFDA306"],"award-info":[{"award-number":["13172KFDA306"]}],"id":[{"id":"10.13039\/501100007603","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2013M3A9D3045879"],"award-info":[{"award-number":["2013M3A9D3045879"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA177932"],"award-info":[{"award-number":["CA177932"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2015,7,13]]},"DOI":"10.1021\/acs.biomac.5b00538","type":"journal-article","created":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T04:32:42Z","timestamp":1434947562000},"page":"2132-2143","source":"Crossref","is-referenced-by-count":24,"title":["Oncolytic Adenovirus Coated with Multidegradable Bioreducible Core-Cross-Linked Polyethylenimine for Cancer Gene Therapy"],"prefix":"10.1021","volume":"16","author":[{"given":"Joung-Woo","family":"Choi","sequence":"first","affiliation":[{"name":"Center\rfor Controlled Chemical Delivery (CCCD), Department of Pharmaceutics\rand Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joung-Pyo","family":"Nam","sequence":"additional","affiliation":[{"name":"Center\rfor Controlled Chemical Delivery (CCCD), Department of Pharmaceutics\rand Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kihoon","family":"Nam","sequence":"additional","affiliation":[{"name":"Center\rfor Controlled Chemical Delivery (CCCD), Department of Pharmaceutics\rand Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Sook","family":"Lee","sequence":"additional","affiliation":[{"name":"Center\rfor Controlled Chemical Delivery (CCCD), Department of Pharmaceutics\rand Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chae-Ok","family":"Yun","sequence":"additional","affiliation":[{"name":"Department\rof Bioengineering, College of Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Wan","family":"Kim","sequence":"additional","affiliation":[{"name":"Center\rfor Controlled Chemical Delivery (CCCD), Department of Pharmaceutics\rand Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, United States"},{"name":"Department\rof Bioengineering, College of Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2015,6,29]]},"reference":[{"issue":"11","key":"ref1\/cit1","first-page":"2623","volume":"59","author":"Heise C. C.","year":"1999","journal-title":"Cancer Res."},{"issue":"2","key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/sj.gt.3301377","volume":"8","author":"Kirn D.","year":"2001","journal-title":"Gene Ther."},{"issue":"2","key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/mt.2009.266","volume":"18","author":"Yamamoto M.","year":"2010","journal-title":"Mol. Ther"},{"issue":"2","key":"ref4\/cit4","first-page":"555","volume":"9","author":"Hecht J. R.","year":"2003","journal-title":"Clin. Cancer Res"},{"issue":"20","key":"ref5\/cit5","first-page":"7464","volume":"61","author":"DeWeese T. L.","year":"2001","journal-title":"Cancer Res."},{"issue":"2","key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ncponc0736","volume":"4","author":"Liu T. C.","year":"2007","journal-title":"Nat. Clin. Pract. Oncol."},{"issue":"21","key":"ref7\/cit7","first-page":"6070","volume":"62","author":"Reid T.","year":"2002","journal-title":"Cancer Res."},{"issue":"8","key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1517\/14712598.4.8.1241","volume":"4","author":"Yamamoto M.","year":"2004","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref9\/cit9","first-page":"61","volume":"90","author":"Yamamoto M.","year":"2004","journal-title":"Methods Mol. Med."},{"issue":"1","key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/sj.cgt.7700769","volume":"12","author":"Yun C. O.","year":"2005","journal-title":"Cancer Gene Ther."},{"issue":"19","key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1158\/1078-0432.CCR-06-0935","volume":"12","author":"Lee Y. S.","year":"2006","journal-title":"Clin. Cancer Res."},{"issue":"20","key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1093\/jnci\/djj397","volume":"98","author":"Kim J. H.","year":"2006","journal-title":"J. Natl. Cancer Inst."},{"issue":"9","key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/gt.2008.3","volume":"15","author":"Yoo J. Y.","year":"2008","journal-title":"Gene Ther."},{"issue":"2","key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/sj.mt.6300023","volume":"15","author":"Yoo J. Y.","year":"2007","journal-title":"Mol. Ther."},{"issue":"2","key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/gt.2009.142","volume":"17","author":"Choi I. K.","year":"2010","journal-title":"Gene Ther."},{"issue":"10","key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"7909","DOI":"10.1128\/JVI.72.10.7909-7915.1998","volume":"72","author":"Roelvink P. W.","year":"1998","journal-title":"J. Virol."},{"issue":"3","key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1517\/17425247.2014.874414","volume":"11","author":"Kasala D.","year":"2014","journal-title":"Expert Opin. Drug Delivery"},{"issue":"4","key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.addr.2006.03.007","volume":"58","author":"Park T. G.","year":"2006","journal-title":"Adv. Drug Delivery Rev."},{"issue":"22","key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399403006562","volume":"5","author":"Parker A. L.","year":"2003","journal-title":"Expert Rev. Mol. Med."},{"issue":"8","key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/sj.gt.3300471","volume":"4","author":"Baker A.","year":"1997","journal-title":"Gene Ther."},{"issue":"2","key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jconrel.2009.11.001","volume":"142","author":"Park J. W.","year":"2010","journal-title":"J. Controlled Release"},{"issue":"8","key":"ref22\/cit22","first-page":"521","volume":"2","author":"Raja-Walia R.","year":"1995","journal-title":"Gene Ther."},{"issue":"5","key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/jgm.696","volume":"7","author":"Akinc A.","year":"2005","journal-title":"J. Gene Med."},{"issue":"3","key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/(SICI)1097-4636(19990605)45:3<268::AID-JBM15>3.0.CO;2-Q","volume":"45","author":"Godbey W. T.","year":"1999","journal-title":"J. Biomed. Mater. Res."},{"issue":"1","key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0168-3659(03)00076-2","volume":"89","author":"Kunath K.","year":"2003","journal-title":"J. Controlled Release"},{"issue":"3","key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1039\/C3NR05024F","volume":"6","author":"Li J.","year":"2014","journal-title":"Nanoscale"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.2147\/IJN.S49595","volume":"8","author":"Zhang L.","year":"2013","journal-title":"Int. J. Nanomed."},{"issue":"10","key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1021\/bc100191r","volume":"21","author":"Liu J.","year":"2010","journal-title":"Bioconjugate Chem."},{"issue":"3","key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1021\/bc000120w","volume":"12","author":"Han S.","year":"2001","journal-title":"Bioconjugate Chem."},{"issue":"3","key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jconrel.2006.12.026","volume":"118","author":"Kim W. J.","year":"2007","journal-title":"J. Controlled Release"},{"issue":"7","key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/sj.gt.3301938","volume":"10","author":"Lee M.","year":"2003","journal-title":"Gene Ther."},{"issue":"4","key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1023\/A:1015166806366","volume":"19","author":"Furgeson D. Y.","year":"2002","journal-title":"Pharm. Res."},{"issue":"2","key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1006\/mthe.2001.0425","volume":"4","author":"Mahato R. I.","year":"2001","journal-title":"Mol. Ther."},{"issue":"15","key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.addr.2005.09.017","volume":"57","author":"Dufes C.","year":"2005","journal-title":"Adv. Drug Delivery Rev."},{"issue":"6","key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.18632\/oncotarget.3018","volume":"6","author":"Lee J. S.","year":"2015","journal-title":"Oncotarget"},{"issue":"9","key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1089\/hum.2006.167","volume":"18","author":"Kim J.","year":"2007","journal-title":"Hum. Gene Ther."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jconrel.2015.01.005","volume":"205","author":"Choi J. W.","year":"2015","journal-title":"J. Controlled Release"},{"issue":"19","key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1016\/j.biomaterials.2013.03.004","volume":"34","author":"Kim J.","year":"2013","journal-title":"Biomaterials"},{"issue":"5","key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/gt.2014.18","volume":"21","author":"Kim J.","year":"2014","journal-title":"Gene Ther."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jconrel.2014.04.012","volume":"190","author":"Lee Y. S.","year":"2014","journal-title":"J. Controlled Release"},{"issue":"1","key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s12272-013-0275-3","volume":"37","author":"Ryu K.","year":"2014","journal-title":"Arch. Pharmacal Res."},{"issue":"8","key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1021\/bm400337f","volume":"14","author":"Tian L.","year":"2013","journal-title":"Biomacromolecules"},{"issue":"3","key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.jconrel.2012.04.025","volume":"160","author":"Nam H. Y.","year":"2012","journal-title":"J. Controlled Release"},{"issue":"21","key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1016\/j.biomaterials.2014.03.060","volume":"35","author":"Lee C. H.","year":"2014","journal-title":"Biomaterials"},{"issue":"2","key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.urology.2005.02.033","volume":"66","author":"Matsumoto K.","year":"2005","journal-title":"Urology"},{"issue":"3","key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0090-4295(02)01748-X","volume":"60","author":"Sachs M. D.","year":"2002","journal-title":"Urology"},{"issue":"7","key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.biomaterials.2009.11.043","volume":"31","author":"Kim P. H.","year":"2010","journal-title":"Biomaterials"},{"issue":"16","key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1089\/hum.1996.7.16-1947","volume":"7","author":"Abdallah B.","year":"1996","journal-title":"Hum. Gene Ther."},{"issue":"6","key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1021\/bc9600630","volume":"7","author":"Tang M. X.","year":"1996","journal-title":"Bioconjugate Chem."},{"issue":"2","key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jconrel.2008.04.014","volume":"130","author":"Intra J.","year":"2008","journal-title":"J. Controlled Release"},{"issue":"4","key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/jgm.187","volume":"3","author":"Wightman L.","year":"2001","journal-title":"J. Gene Med."},{"issue":"2","key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0168-3659(99)00090-5","volume":"60","author":"Godbey W. T.","year":"1999","journal-title":"J. Controlled Release"},{"issue":"9","key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/sj.cgt.7700494","volume":"9","author":"Kim J.","year":"2002","journal-title":"Cancer Gene Ther."},{"issue":"6","key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.ymthe.2006.07.007","volume":"14","author":"ter Brake O.","year":"2006","journal-title":"Mol. Ther."},{"issue":"1","key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1096\/fj.01-0421fje","volume":"16","author":"Abounader R.","year":"2002","journal-title":"FASEB J."},{"issue":"22","key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1016\/j.biomaterials.2011.03.084","volume":"32","author":"Kim J.","year":"2011","journal-title":"Biomaterials"},{"issue":"38","key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"5286","DOI":"10.1038\/onc.2010.267","volume":"29","author":"Cantelmo A. R.","year":"2010","journal-title":"Oncogene"},{"issue":"8","key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.addr.2011.12.011","volume":"64","author":"Choi J. W.","year":"2012","journal-title":"Adv. Drug Delivery Rev."}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.5b00538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T02:17:09Z","timestamp":1681697829000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biomac.5b00538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,29]]},"references-count":58,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7,13]]}},"alternative-id":["10.1021\/acs.biomac.5b00538"],"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.5b00538","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,29]]}}}