{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:23:11Z","timestamp":1788445391038,"version":"build-2803163510"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>An important adaptation for diabetes patients is the consumption of artificial sweetener aspartame, which is present in more than thousands of food products and medicines. Several studies have shown diverse side effects of aspartame, and it is also known to form amyloid-like cytotoxic and cross-seeding-competent nanostructures. Here, we reveal a direct crosstalk between aspartame and insulin that induces their cross-seeding and coaggregation events. Insulin\u2019s cross-\u03b2 structure possesses high affinity for aspartame and triggers its self-assembly into cytotoxic nanostructures. Likewise, aspartame nanostructures were found to trigger the amyloid aggregation of insulin. The coaggregates of aspartame and insulin display amyloid-like structural and biophysical characteristics, and possess potential to initiate cross-seeding reactions. Importantly, unlike insulin fibrils, the aspartame\u2013insulin coassembled fibrils were found to be peptidase-resistant and cytotoxic. The results indicate the interplay between insulin fibrillation and aspartame aggregation, which signifies a possible link between the progression of diabetes-associated complications and the consumption of aspartame.<\/jats:p>","DOI":"10.1021\/acs.biomac.5c00286","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T16:00:21Z","timestamp":1756396821000},"page":"6405-6417","source":"Crossref","is-referenced-by-count":3,"title":["Molecular Crosstalk\nbetween Artificial Sweetener Aspartame\nand Diabetes-Linked Insulin Hormone Unveils Possible Amyloidosis Risks"],"prefix":"10.1021","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7253-1984","authenticated-orcid":true,"given":"Masihuzzaman","family":"Ansari","sequence":"first","affiliation":[{"name":"Jawaharlal Nehru University , , ,","place":["New Delhi, India, 110067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4931-3679","authenticated-orcid":true,"given":"Kailash Prasad","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru University , , ,","place":["New Delhi, India, 110067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Mittal","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru University , , ,","place":["New Delhi, India, 110067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishali","family":"Bhati","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru University , , ,","place":["New Delhi, India, 110067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vartika","family":"Gupta","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru University , , ,","place":["New Delhi, India, 110067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shraddha","family":"Mishra","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru University , , ,","place":["New Delhi, India, 110067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Patidar","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru University , , ,","place":["New Delhi, India, 110067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3512-1534","authenticated-orcid":true,"given":"Om Prakash","family":"Mahato","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru University , , ,","place":["New Delhi, India, 110067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurgha Kamal","family":"Bhandari","sequence":"additional","affiliation":[{"name":"SRM Institute of Science and Technology , , , ,","place":["Kattankulathur, Tamil Nadu, India, 603203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7339-6657","authenticated-orcid":true,"given":"Bibin Gnanadhason","family":"Anand","sequence":"additional","affiliation":[{"name":"SRM Institute of Science and Technology , , , ,","place":["Kattankulathur, Tamil Nadu, India, 603203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-6539","authenticated-orcid":true,"given":"Karunakar","family":"Kar","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru University , , ,","place":["New Delhi, India, 110067"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"issue":"suppl_2","key":"2026081812185220800_cit1","doi-asserted-by":"publisher","first-page":"S253","DOI":"10.2337\/dc09-S318","article-title":"Insulin therapy for type 2 diabetes","volume":"32","author":"Swinnen","year":"2009","journal-title":"Diabetes Care"},{"issue":"5","key":"2026081812185220800_cit2","doi-asserted-by":"publisher","first-page":"397","DOI":"10.2169\/internalmedicine.49.2633","article-title":"Localized\namyloidosis at the site of repeated insulin injection in a diabetic\npatient","volume":"49","author":"Shikama","year":"2010","journal-title":"Intern. 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